Category Archives: Africa

One world, one health

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Holistic approaches to controlling the 'perfect storm' of health problems in poor countries, particularly Africa's catastrophic disease burden, must include better control of diseases transmitted between animals and people.

A paper to be published this May 2006 in the Public Library of Science (PLoS) journal PLoS Medicine, a peer-reviewed open-access journal (available online at www.plosmedicine.org) advocates linking integrated work on ‘neglected’ tropical diseases with major global health partnerships recently formed to tackle the three most devastating diseases of the poor: malaria, TB and AIDS. The authors of the paper, which include development economist Jeffrey Sachs, argue that while new partnerships and initiatives have significantly raised funding and awareness of the need to scale up the fight against the ‘big three’ diseases, conspicuously absent is work on a group of ‘neglected tropical diseases’ that may threaten the poor as much as malaria, TB and AIDS and for which there are already cheap and effective control strategies. The authors propose that our success in controlling the big three may depend on a concurrent attack on this group of neglected diseases, which include three vector-borne protozoan infections (leishmaniasis, human African trypanosomosis and Chagas disease), three bacterial infections and seven kinds of helminth (worm) infections.

The potential benefits of taking a more holistic approach to disease control are being popularized in complementary initiatives advocating ‘one health’ strategies that simultaneously address human and animal health. (See, for example, a new book exploring grass roots ideas from East and Southern Africa on how to integrate wildlife, livestock and human health for both conservation and development: ‘One World, One Health’ is available online from LEAD, the Livestock, Environment and Development Initiative.

ILRI supports these holistic health approaches and further argues that another class of neglected diseases of the poor—‘zoonotic’ diseases, or those transmitted between people and animals—should be included. Zoonotic diseases account for a remarkable 75% of all human diseases and include such emerging diseases as avian influenza. Esther Schelling, a veterinary epidemiologist on joint appointment with the International Livestock Research Institute (ILRI) and the Swiss Tropical Institute, points out that zoonotic diseases are virtually excluded from most health initiatives ‘because they’re simply not accounted for’. ILRI is helping to ensure that they are accounted for and that methods to control them are friendly to the poor.

Two papers on this topic by Schelling and colleagues are available online:
British Medical Journal article
Lancet article

Carlos Seré, director general of ILRI, says that with the sequence in recent years of BSE (‘mad cow disease’), foot-and-mouth disease, and now bird flu, there is definitely increasing interest in zoonotic diseases.

‘Donors like the Welcome Trust’, he says, ‘are increasing their investment in tropical animal disease research. Our own strategy is to develop appropriate methods for researchers and policy-makers to evaluate the risk of these zoonotic diseases and together identify the most promising strategies and policies that can help to reduce such risk, particularly for the poor. We have activities specifically looking at zoonoses such as brucellosis and bovine TB, and we are building up our expertise in food safety issues. Strengthening our expertise on food safety and the risks posed by zoonoses is central to two of ILRI’s strategic research themes, the first on sustaining lands and livelihoods which involves protecting human health, and the second on improving livestock-related market opportunities in domestic and international markets, which are increasingly threatened by such food safety concerns.’

In relation to bird flu, Dr Seré explains, ‘ILRI will not be the virologists or poultry specialists. But we have comparative strength in systems analysis, which combines social science with epidemiology and animal genetics and other lab bench research to address complex health problems. We do this in conjunction with partners who bring more specific expertise, such as in poultry or vaccines. What we specifically bring to the picture is a “poverty lens” to understand the implications of health problems, issues and control strategies on the poorest populations in the world.’

‘Clearly, research is not a “rapid deployment tool”’, he says. ‘There are other organizations—such as the World Health Organisation (www.who.org), the Food and Agriculture Organization of the United Nations (www.fao.org), and the World Animal Health Organisation (www.oie.org) —that have a regulatory mandate and policy responsibility and are linked directly to governments. ILRI’s comparative advantage is in the longer term: in understanding the issues and in providing sound technical research to back these agencies which are doing the short-term response work. As we see more and more that boundaries don’t work, that disease is a global problem, we encourage industrialized countries to share their resources with developing countries, not just out of enlightened self-interest, but also, for example, to ensure food safety for their domestic consumers. And finally, we are particularly interested in helping developing countries to build their own research capacity to understand, model and control complex disease problems.

The collective power of smallholder farmers

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Kenya's new Dairy Development Policy aims to bring Kenya's estimated 39,000 informal milk traders into the formal sector.

BBC World Service began to broadcast a Kenya dairy story on 6 April 2006, the same day Kenya’s Minister for Livestock and Fisheries Development, Joseph Munyao, presented a new Dairy Development Policy in Nairobi – the final step before the new Policy and accompanying Dairy Development Bill are presented to Kenya’s Parliament.

Kenya’s new Dairy Policy now broadly reflects the approach the International Livestock Research Institute (ILRI) and its partners have advocated over the past several years – the need to engage with and develop the country’s hugely important informal milk market, which provides a livelihood to an estimated 1.8 million smallholder households.

The new Dairy Policy now clearly acknowledges the role of the informal market actors in the development of the sector. The policy states that it will ‘facilitate the transformation of the informal milk trade towards formalisation’. Specific measures mentioned include development of low-cost and appropriate technologies for small investors, training programmes on safe milk handling, efforts to improve the standards of milk processing in the informal sector, provision of incentives for improved milk handling, and establishment of a supportive milk dealer certification system. The Dairy Policy also announces that the Kenya Dairy Board functions will be streamlined and steps will be taken so that the Board regulates itself and is managed by its stakeholders.

The new Dairy Policy is a huge step forward in a struggle that has been ongoing since 1998, when Kenya’s big milk buyer (Kenya Co-operative Creameries) went into liquidation. Various attempts were subsequently made to oust smallholders from the market, including media campaigns advising that unpasteurized (‘raw’) milk was unsafe and should not be consumed. The BBC Kenya Dairy Story, broadcast on its World Service, tells how the smallholders, supported by ILRI and partners, fought back, and how they are now being brought into the formal milk market. The Kenya Dairy Story was broadcast from 6-13 April 2006.

Small is Beautiful – The Kenya Dairy Story
Kenyans love their milk. Most of the 4 billion litres consumed there each year is produced by smallholders with a couple of cows, and sold house-to-house by thousands of street hawkers and doorstep milkmen. But this whole milk business was under threat. In the third edition of the One Planet series (on BBC World Service) which is sharing small business success, Susie Emmett discovers how the farmers and traders fought back to keep the milk flowing.


Listen to a recording of the BBC World Service broadcast produced by WRENmedia.

Note: The latest numbers

Some of the numbers quoted in this BBC World Service broadcast ‘Small is beautiful’ have been obtained from much earlier estimates. These figures, however, grossly understate the true size and extent of Kenya’s milk sector. SDP has provided recalculated figures, which more accurately reflect the picture in Kenya today.

1. Smallholder dairy farms recalculates to be 1.8 million (up from 800,000)

The estimated 800,000 smallholder farms has been widely cited for many years, during which time Kenya’s population has grown significantly. SDP recalculates the number of smallholders to be 1.8 million.

2. Milk hawkers recalculated to be 39,650 (up from 30,000)

SDP recalculates the number of small milk vendors in Kenya to be 39,650.

3. Number of dairy cattle recalculated to be 6.7 million (up from 3 million)
There are concerns about the reliability of the official cattle figures for Kenya; no livestock census has been conducted for decades and the methods used to estimate cattle numbers are imprecise. A conservative estimate of the size of the national dairy herd using detailed SDP survey data suggests that there are about 6.7 million dairy cattle (2.7 million high grade and 4 million crosses) owned by 1.8 million rural smallholder farms mainly in the Kenyan Highlands. This projected cattle population is more than twice the officially reported figure of 3 million for the national herds.

4. Total milk produced recalculated to be 4 billion litres per annum (up from 3 billion)
Based on SDP’s recalculated cattle projections above, SDP recalculates total milk production in the rural highlands to be an estimated 4 billion litres per annum.

5. Annual consumption of milk recalculated to be 145 litres per person (up from 100 litres)
SDP recalculates annual milk consumption by Kenyans to be 145 litres per person, making Kenyans amongst the highest milk consumers in the developing world. The rural areas have an estimated population of about 14.5 million people. Assuming that the estimated 9.6 million people living in the urban areas mainly depend on milk from the high potential areas, and that 13 percent of production goes to calf feed or spoilage loss, milk availability from the highlands was estimated to be about 145 litres per person per year. Previously, milk consumption in Central and Rift Valley provinces, which are important milk production areas, has been estimated to be between 144 and 152 litres per person per year.

Source: SDP Policy Brief No.10.

Highlights from the Kenya Dairy Story broadcast by BBC World Service:
In Kenya, a knock on the door means the milkman is here – today as everyday – delivering fresh raw milk to one of his many grateful customers. “I like this milk because this one comes daily, and it is fresh and good, that’s why I like it” says one of his customers.


This milk vendor serves approximately 60 customers, and sells approximately 100 litres of raw milk, each and every day. In Kenya, more than 30,000 milk hawkers [recalculated in August 2006 to be 39,650] are out daily on their bicycles or pushing carts to deliver nutritious milk from 800,000 small dairy farms [recalculated in August 2006 to have risen to 1.8 million].

Despite all its success, this whole wonderful milk business was under threat. The government here, as in so many countries, decided that small-scale farmers and traders couldn’t supply milk as safely as large farms and dairies. So, how come the hawkers are still in business, as are the smallholder dairy farmers whose milk they sell?

Kenya has three million improved dairy cattle [recalculated in August 2006 to have risen to 6.7 million] – that’s the largest dairy herd in Africa – and most of them are on small farms. Almost half the three billion litres of milk they produce are sold direct from small farms to households nearby. So the question is, can smallholder farmers produce clean, safe milk? Research by ILRI and others says yes – and changed lives because of it.

But what about that other all-important business criteria: efficiency; are the smallholder dairy farmers here in Kenya efficient? Steve Staal, agricultural economist at ILRI, says research shows smallholder dairy farmers are actually very competitive. ‘Indeed, small-scale mixed crop-and-livestock production is likely to be a more sustainable way to intensify agricultural production in environmental terms than large-scale industrial livestock production’, says Staal.

The biggest threat to smallholders came a few years ago when the one big buyer in Kenya – The Kenya Cooperative Creameries – went bust. Government policies did not recognize the small-scale operators and thus they were deemed to be operating illegally. Amos Omore is part of the team at ILRI trying to boost dairy incomes for the poor. He remembers how big dairy business was not going to let Kenya’s 800,000 [1.8 million] new milk entrepreneurs get in their way. It was a clash between big and small.

Kenya’s official ban on milk hawking was based on the milk not being safe. The nation’s newspapers carried many such stories. In the face of this scare-mongering, researchers got researching. David Mwangi at the Kenya Agricultural Research Institute (KARI), says that the public health risks being talked about were minimal – ‘almost not there’.On average, Kenyans drink 100 litres of milk a year, [recalculated in August 2006 to be 144–152 litres of milk a year] making them among the highest milk consumers in the developing world. But they don’t drink milk as it comes. ILRI’s Omore says the research showed that most consumers boil fresh milk before drinking it, which makes it as safe as pasteurized milk.

Gathering this evidence was a huge step. Using that evidence to change policy and mindsets was another.


KARI’s Mwangi says, ‘We worked with advocacy groups and hosted a high-profile meeting. And we had facts to table there.’ This research helped lead to the Kenya Dairy Board approving training for smallholder milk producers and traders. That’s important: most members of smallholder dairy cooperatives depend on their milk money to educate their children. Furthermore, easing restrictions against small traders helps poor customers because of the price of processed milk is beyond the means of most poor people here.’

John Kutwa, a former ILRI technician in the dairy team, says that ‘small’ characterizes most of Kenya’s milk business. ‘It’s small farmers selling to small traders and processors who deliver to small (poor) consumers.’


ILRI’s Amos Omore has been battling on behalf of smallholder milk producers and sellers since their troubles began. And he’s battling still. ‘Right now the policy environment has shifted towards small-scale traders’ he says. But the change is not yet complete. Small businesses are important but often overlooked.

‘Changing policies takes time’, he says, ‘and so does changing attitudes. In this country in the 1960s and 70s, it was always assumed that development projects should be “mega” to achieve some quantum leap in development. But if you look at development holistically – in terms of employment, in terms of nutrition, in terms of cash flow – these are the stepping stones that allow people to move from one living standard to the next. Small is beautiful!  Small should not be sacrificed at the altar of large-scale businesses that often fail.’

International Women’s Day, 8 March 2006

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Africa's women livestock farmers fulfill on Africa's renewal
 
To celebrate International Women's Day (http://www.internationalwomensday.com/) today, ILRI highlights a few of the major contributions made by Africa’s ‘WILD’ women—‘Women in Livestock Development’—to the continent’s renewal through economic, nutritional and environmental security.

Millions of women livestock farmers remain the majority of African farmers, the backbone of African agriculture, the food-security managers of African households, and the key to Africa’s renewal.

Why livestock? Because livestock ownership by women is more common than land ownership. Because even landless women are raising small domesticated animals to feed, clothe and educate their children. Because increasing women’s access to farm animals—the ‘living assets’ most commonly available to the poor worldwide—is a ready way to empower women otherwise severely marginalized.

African Women's Contribution to African Agriculture

A Fairer Deal for Women


Identifying the Real Farmer

Milk, Eggs and Meat


Women's Roles and Ownership of Assets


Increasing Assets in Women's Hands


Pro-Women Approaches to Technology Development and Selection

Women Farmers Uptake of Disease Control Methods

Women's Preferred Livestock: Income Distribution and Time Costs

Disease control: Protecting Women's Preferred Livestock

Women's Access to Technologies and Know-How

Vulnerability to Effects of Livestock Diseases

Click here for resource documents and further information

WILD Contributors: Susan MacMillan, Janice Njoroge, Grace Ndungu, Maria Mulindi, Christine Thuranira and Margaret Macdonald-Levy.

ILRI vaccine advances published in February 2006 PNAS journal

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Public-private partnership makes major step towards improving livestock health and reducing poverty.

The devastating effects of East Coast fever on the livelihoods of small-scale farmers may one day be a thing of the past as a team of international scientists moves closer towards the development of a vaccine.

“East Coast fever is an intractable problem that ravages cattle of the poor in Africa. The good news is that this can be solved by high-tech science and technological innovations, achievable through strategic partnerships’’. Evans Taracha – ILRI East Coast Fever Vaccine Project Leader

Every year, East Coast fever destroys the small farmer’s dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National Academy of Sciences (PNAS), shows how genomics can generate pivotal new vaccines.

In the study, scientists from five institutions, including the International Livestock Research Institute (ILRI) and The Institute for Genomic Research (TIGR), identify five vaccine targets, or candidate proteins that could form the basis for an East Coast fever subunit vaccine. Based on combined bioinformatics analyses and lab tests, these proteins appear to provide a protective immune response to the disease. “This initiative took just three years, after many years of scientists trying other methods,” remarks Vishvanath Nene, former ILRI staff member, a study author and molecular biologist at TIGR. “It’s a huge jump forward.”

To make the jump, researchers used the genome sequence of the parasite responsible for East Coast fever. A tick-borne parasite, Theileria parva, causes the disease. When ticks infected with T. parva bite cattle, they transmit the parasite, launching the disease that typically kills cattle within a month. In July, 2005, TIGR led a research team that published T. parva’s genome sequence, representing roughly 4,000 genes, in Science.

In the current study, Nene, along with Malcolm Gardner and Claire Fraser-Liggett, also of TIGR, relied on known biology to search T. parva’s genome for potential vaccine proteins. First, scientists know that immunity to the parasite, and thus East Coast fever, emerges from immune system cells known as killer T cells. Second, they know that T. parva is an intracellular pathogen–it infects and secretes proteins inside cattle white blood cells, which become malignant. The white blood cell then unwittingly passes small fragments of the secreted parasitic proteins associated with a certain type if its own proteins along to its cell surface. And this is where a vaccine could come in: A vaccine made of the T. parva proteins found on the surface of host cells should trigger an immune response in cattle. Vaccinated cattle would then be protected from the parasite.

To find potential vaccine antigens, the TIGR researchers scanned T. parva’s entire genome for genes that make secreted proteins. In particular, they searched for genes that make a “secretion signal,” a telltale peptide sequence found at the start of secreted proteins. Sure enough, the scientists found some 400 T. parva genes containing the secretion signal. This set of genes provided a starting pool of candidate proteins. Based on further tests, the study’s research team, led by ILRI of Nairobi, Kenya, cloned 55 candidate antigen genes and screened those genes for response by killer T cells taken from cattle immune to East Coast fever. To complement TIGR’s gene selection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates.

In total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T cells. Going a further step further, the scientists inoculated cattle with these antigens and then gave the cattle a potentially lethal dose of T. parva. When compared with control animals, vaccinated cattle showed significantly stronger immune response to the parasite.

“This study is a true milestone,” says Fraser-Liggett, president of TIGR. “It’s one of the first to take advantage of genomic technologies and build a test vaccine using immune killer T cells as a screening reagent.” In addition to TIGR and ILRI, the research team included scientists from: the Ludwig Institute for Cancer Research in Brussels; the Wellcome Trust Center for Human Genetics in Oxford; Sanofi Pasteur in Toronto; the University of Edinburgh; and Merial SAS, an international animal health company. ILRI and Merial have partnered to develop a vaccine against East Coast fever.

By using genomics to understand and fight T. parva, scientists may make advances against related parasites that cause malaria, tuberculosis, and other diseases in which killer T cells also play a role in immunity. What’s more, because T. parva launches a cancer-like illness inside the white blood cells of cattle, it may provide a model system for understanding the mechanics of cancer biology.

But for Nene, who was born in Kenya and worked at ILRI for 15 years before coming to TIGR in 2001, the march against East Coast fever is significant reward, itself. “This disease takes an enormous toll on the local society and economy of rural areas across eastern and central Africa, including Maasai and other pastoral communities,” he says. In particular, East Coast fever kills cattle kept by families trying to rise out of poverty. If researchers are successful, Nene notes, the entire region will have new reason to hope for a better life. Evans Taracha, ILRI project leader, also highlights the importance of strategic research partnerships to overcome this and similar diseases.

TIGR’s portion of the PNAS study was funded independently by TIGR and by sub-contract from the Animal Health Program of the United Kingdom Department for International Development, with previous contributions from J. Craig Venter and the ILRI for the T. parva genome project.

Experts meet in Nairobi, project futuristic livestock scenarios for developing countries

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Group of 25 experts enters 'uncharted waters' in building futuristic livestock scenarios that force new thinking and new decisions.

The International Livestock Research Institute (ILRI) and the Food and Agriculture Organization of the United Nations (FAO) hosted a group of 25 livestock and futures experts from around the world for two and a half days 13–15 February 2006 to do some non-crystal-ball-gazing. The experts constructed alternative scenarios of likely futures of livestock development in developing countries, paying particular attention to what will happen to poor people.

They got help from, Jerome Glenn, who is an expert in ‘futures research’ and director of a think tank called the Millennium Project, which has been running under the aegis of the American Council for the United Nations University since 1991.

Decision-makers in ILRI and FAO and other livestock research and development institutions are the target of the products of this meeting. The idea behind this work is to force serious, flexible thinking about alternative possibilities for the future and begin to come up with the right mix of strategic decisions that will allow people to adapt to the future. The process of doing this work can alter the way decision makers think about the future. That, says Glenn, may be the most important outcome of the meeting.

‘The germ of a future-oriented collective intelligence on livestock development for the poor was created here,’ Glenn said at the close of the meeting. ‘What we believe is possible for livestock development is “pretty poultry”’, he punned. ‘Here, for example, are just a few of the things that were not yet in the world in 1980: personal computers, the World Wide Web, cellular phones, AIDS, the European Union and the World Trade Organisation. The world has changed dramatically in the last 25 years. What is guaranteed is that we will have even more and faster changes in the future. This meeting was held to enlarge the capacity of stakehol