Scissors and crazy glue: Lorne Babiuk, award-winning vaccine evangelist, speaks his (clear) mind in Ottawa

Posted on October 9, 2013 by Susan MacMillan

Director of ILRI’s vaccine development program Vish Nene (left) with Canadian vaccinologist and ILRI board member Lorne Babiuk (right) at morning tea with ILRI staff (photo credit: ILRI/Susan MacMillan).

Canadian Lorne Babiuk, an internationally recognized leader in vaccine research, visited the International Development Research Centre (IDRC) in Ottawa yesterday (8 Oct 2013) to deliver a live webcast talk on exciting breakthroughs in the development of animal vaccines, which, he argued, can both improve global food security and reduce the global impacts of infectious diseases.

Babiuk is vice-president of research at the University of Alberta and the recipient of two recent distinguished awards for his outstanding career in vaccinology — the Gairdner Wightman Award in 2012 and the Killam Prize in Health Sciences in 2013. He serves on the board of trustees of the International Livestock Research Institute (ILRI).

For all his illustrious awards, Babiuk talked not like a scientist but rather like ‘a regular guy’, preferring to speak of ‘scissors’ and ‘crazy glue’ to describe molecular advances in vaccinology rather than use scientific jargon.

Here’s some of what he said.

ON POVERTY
One billion people go to bed hungry every night. Not hungry like you and me when we miss a meal. But hungry, really hungry, every day, day in and day out. By 2050, we’ll have another 2 billion people to feed. The last time I checked, they were not making more land. So we’re going to have to do more with the land (and livestock) that we have. We have an opportunity to develop new approaches to increase food supplies or to have a lot more hungry people.

The developing world is looking for more and more protein; those of us in the developed world should not deny them that.

Livestock are a critical component of smallholder farming, which supports about two billion people, some two-thirds of them women

ON DISEASE
I’ve spent my career in infectious diseases. They matter partly because they cost so much. Alberta has still not recovered from BSE. And SARS cost a staggering USD100 billion—USD2 billion in Ontario alone.

Some 74% of new or emerging diseases are ‘zoonotic’, which means they’re transmitted from animals to humans, or from humans to animals. The economic impacts of zoonoses are huge for farmers, for producers, for international traders . . .

ON DISEASES OF THE DEVELOPING WORLD
I have concerns about Rift Valley fever spreading to North America. The West Nile virus, which has the same kind of vector, has already arrived here.

ON BIOTECH
Technology and biotechnology can be a saviour, but it’s a challenge because we have a large number of people against genetically modified food. We have to work with social scientists to make sure we have healthy animals for healthy people

ON RESEARCH
Basic research and applied research are two sides of the same coin—the two of them need each other.
We no longer train our biologists in broad biology but rather in narrower molecular biology studies. That’s a mistake.
We biological scientists must get smarter at engaging social science and scientists.

ON VACCINES
Vaccination has saved more lives than all other treatments and prophylactics combined.
The traditional types of vaccines, live or killed, have given way to really interesting new types.
We eradicated smallpox with a vaccine; that research would never be approved today because the vaccine has too many side effects.
What can we do to change perceptions of vaccines and biotechnology?
It costs something in the order of one billion dollars to get a vaccine approved.

ON VACCINES FOR THE DEVELOPING WORLD
The major obstacle in Africa is to get a commercial company to invest in the regulatory component of a vaccine because there isn’t a financial incentive. You can’t sell a livestock vaccine for much more then 50 cents per dose in a developing countries. That’s why we have to work with African or Asian vaccine companies, which can produce vaccines much cheaper than industrial countries can.

Several diseases in the developing world are protozoan and those are, of course, much bigger challenges. But there have been new donors for protozoan vaccine research. We need to convince more donors that this research is needed.

ON THE ANTI-VACCINE LOBBY
I’m an evangelist for vaccination because I think we have lost the battle to the anti-vaccine lobby. In North Amercia there is a huge anti-tech group. They misquote or use data to push their own agenda at the expense of large numbers of lives lost. Look at the article published decades ago about a possible link between vaccination and autism. Despite decades of subsequent research showing no such links, we still haven’t managed to convince a lot of people that vaccines do not cause autism.

How do we encourage the scientific community to stand up and be more vocal about what they know? We have to continue to advocate and demonstrate what we can do using the new technology. We should promise less and deliver more. We have been our own worst enemies. We have to be realists and say what can be done in what time period. That will give us back some credibility.

People go into science because they like doing the science part of it. If they loved the podium, they would have gone into the social sciences. We need to encourage others to do this kind of communication.

ON TEAM DYNAMICS
Any successful researcher has to stimulate the team around him or her and make them all feel part of something big. Getting people excited about working together as a team, providing a vision, and saying how the team can achieve something, that’s what I’m good at. Get people passionate about something and get them to know it’s their idea. I’m a facilitator. I don’t tell people what to do. I create an environment that facilitates what they do. You have to accept different cultures, different ways of doing science. You have to have patience and go with the flow. I learned patience.

ON HIS SUCCESSFUL CAREER
I still get up in the morning and put one leg in my pants and then the other, just like everyone else.

About CIFSRF
Lorne Babiuk manages a grant funded by the Canadian International Food Security Research Fund (CIFSRF), among others. CIFSRF is a CA$124.5-million program of IDRC undertaken with financial support from the Government of Canada. CIFSRF supports applied research partnerships between Canadian and developing-country organizations to find lasting solutions to hunger and food insecurity. It is a core element of Canada’s Food Security Strategy.

For more information, see the IDRC website.

ILRI geneticist wins prestigious ‘BREAD Ideas Challenge’ award for innovative way to improve livestock breeding services in poor countries

Posted on August 19, 2013 by Paul Karaimu

Fidalis Mujibi, a geneticist at ILRI, collecting information from a smallholder livestock farmer in Busia, Kenya. Mujibi is one of the winners of the 2013 ‘BREAD Ideas Challenge’ award for an idea to improve livestock breeding services (photo credit: BMGF/Lee Klejtnot).

Fidalis Mujibi, a Kenyan geneticist working with the International Livestock Research Institute (ILRI) in Nairobi, is one of the winners of the 2013 USD10,000 ‘BREAD Ideas Challenge’, announced in July.

The award is given each year by the American National Science Foundation and is part of the ‘Basic Research to Enable Agricultural Development (BREAD) program, which is co-funded by the National Science Foundation and the Bill & Melinda Gates Foundation. This year, the award recognized 13 innovators amongst many applicants ranging from scientists, professors and graduate students from around the world. The winning challenges focused on ideas of solving pressing and largely ignored issues affecting smallholder farming in developing countries.

Mujibi received the award together with American scientist and beef reproductive management specialist George Perry, from South Dakota State University. Their idea is to eliminate the need for liquid nitrogen in livestock artificial insemination services in developing countries.

Liquid nitrogen is needed to preserve the semen used to inseminate dairy cows artificially, but it’s expensive and raises the costs of artificial insemination services for poor farmers in developing countries. Most of those providing artificial insemination services are unable to maintain a steady supply of liquid nitrogen in their tanks, leading to cases of dead semen being used for insemination. This in turn necessitates many repeated insemination procedures, which not only are unduly expensive but also result in long calving intervals, reducing the lifetime productivity of cows.

‘Our idea focuses on alternatives that could eliminate the “cold-chain” from the artificial insemination delivery process’, says Mujibi. ‘We’re exploring ways of delivering semen to remote villages in Africa where there is no infrastructure to support liquid nitrogen systems, so that farmers can access the germplasm they need easily.’

‘I want to explore new ways of helping Africa’s smallholder farmers to improve their livestock production through new germplasm delivery and novel reproductive tools. This will help them better cope with pressures from climate change and reduced farmland,’ says Mujibi.

Mujibi and Perry are preparing a full proposal they will submit to the American National Science Foundation in September.

‘The BREAD challenges range from the global to the local and across diverse disciplines’, said John Wingfield, assistant director for biological sciences at the National Science Foundation. ‘What they have in common is that they represent topics that have not had the attention or funding to prompt a solution. Solving any of these challenges would have a dramatic impact on the lives of millions of smallholder farmers around the globe.’

Read more information about the BREAD award:

http://www.nsf.gov/news/news_summ.jsp?cntn_id=128546&org=NSF&from=news

Find out more about ILRI’s work in livestock genetics

https://newsarchive.ilri.org/archives/tag/dairy-genetics-east-africa-project

https://www.ilri.org/node/598

‘Livestock Research for Africa’s Food Security’: Join us at our side event at FARA’s AASW in Accra, 15 July

Posted on July 9, 2013 by Susan MacMillan

Next week, staff of the International Livestock Research Institute (ILRI) and many other CGIAR centres and research programs are attending the 6th Africa Agriculture Science Week (AASW6), which is being hosted by the Forum for Agricultural Research in Africa (FARA) and the Government of Ghana and runs from Monday–Saturday, 15–20 Jul 2013.
CGIAR is a global partnership for a food-secure future that conducts and disseminates research to improve the lives, livelihoods and lands of the world’s poorest people. CGIAR research is conducted by 15 of the world’s leading agricultural development research centres and 16 global research programs, all of them partnering with many stakeholders in Africa. More than half of CGIAR funding (52% in 2012) targets African-focused research.

The theme of next week’s AASW6 is ‘Africa Feeding Africa through Agricultural Science and Innovation’. CGIAR is supporting African-driven solutions to food security by partnering with FARA and the African Union, the Comprehensive Africa Agriculture Development Programme (CAADP), sub-regional organizations, national agricultural research systems and many other private and non-governmental as well as public organizations.

ILRI and livestock issues at AASW6

Ten ILRI scientists and staff will briefly speak and then engage with other participants in a side event ILRI is organizing at AASW6 on the topic of Livestock research for Africa’s food security. This three-hour morning side event will be facilitated by ILRI’s knowledge management and communication specialist, Ewen Le Borgne, and will be highly participatory in nature.

If you plan to attend this session, please shoot an email confirmation to Teresa Werrhe-Abira(t.werrhe-abira [at] cgiar.org) so we can organize refreshments.

And if you’d like to use this opportunity to talk with or interview one of the ILRI staff members below, or just meet them, please do so! ILRI communication officers Muthoni Njiru (m.njiru [at] cgiar.org) and Paul Karaimu (p.karaimu [at] cgiar.org) will be on hand at the ILRI side session (and you’ll find one or both at the CGIAR booth most of the rest of the week) to give you any assistance you may need.

Among the speakers at the ILRI side session will be the following.

Jimmy Smith: Livestock and the global development agenda

Jimmy Smith, a Canadian, became director general of ILRI in Oct 2011. Before that, he worked for the World Bank in Washington, DC, leading the Bank’s Global Livestock Portfolio. Before joining the World Bank, Smith held senior positions at the Canadian International Development Agency. Still earlier in his career, he worked at ILRI and its predecessor, the International Livestock Centre for Africa (ILCA), where he served as the institute’s regional representative for West Africa and subsequently managed the ILRI-led Systemwide Livestock Programme of the CGIAR, involving ten CGIAR centres working at the crop-livestock interface. Before his decade of work at ILCA/ILRI, Smith held senior positions in the Caribbean Agricultural Research and Development Institute (CARDI). Smith is a graduate of the University of Illinois at Urban-Champaign, USA, where he completed a PhD in animal sciences. He was born in Guyana, where he was raised on a small mixed crop-and-livestock farm.

John McIntire: Africa’s integrated crop-livestock systems

John McIntire (USA) is ILRI deputy director general for research-integrated sciences. He obtained a PhD in agricultural economics in 1980 from Tufts University using results of farm-level field studies of smallholder crop production in francophone Africa. He subsequently served as an economist for the International Food Policy Research Institute (IFPRI), in Washington, DC, and the West Africa Program of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), in Burkina Faso and Niger, and the International Livestock Centre for Africa (ILCA), one of ILRI’s two predecessors, in Ethiopia. He is co-author of Crop Livestock Integration in Sub-Saharan Africa (1992), a book still widely cited 20 years later. McIntire joined the World Bank in 1989, where he worked (in Mexico, Côte d’Ivoire, Senegal, The Gambia, Cape Verde, Guinea, Tanzania, Uganda and Burundi) until his retirement in 2011. In 2011, he became the second person to receive both the Bank’s ‘Good Manager Award’ and ‘Green Award for Environmental Leadership’.

Shirley Tarawali: ILRI’s new long-term strategy, 2013–2022

Shirley Tarawali (UK) is ILRI director of institutional planning and partnerships. Before taking on this role, Tarawali was director of ILRI’s People, Livestock and the Environment Theme, with responsibilities spanning sub-Saharan Africa and Asia. She holds a PhD in plant science from the University of London. Previously, Tarawali held a joint appointment with ILRI and the International Institute of Tropical Agriculture (IITA), based in Ibadan, Nigeria. Her fields of specialization include mixed crop-livestock and pastoral systems in sub-Saharan Africa and Asia.

Delia Grace: Food safety and aflatoxins

Delia Grace (Ireland) is an ILRI veterinarian and epidemiologist who leads a program at ILRI on food safety and zoonosis. She also leads a flagship project on ‘Agriculture-Associated Diseases’, which is a component of the CGIAR Research Program on Agriculture for Nutrition and Health, led by the International Food Policy Research Institute (IFPRI), USA. Grace has broad developing-country expertise in food safety, risk factor analysis, ecohealth/one health, gender and livestock, participatory methods, randomized trials and health metrics.

Questions Grace will address in ILRI’s side event are:
What are risk-based approaches to food safety in informal markets where most of the poor buy & sell?
How should we deal with food safety dynamics: livestock revolution, urbanization, globalization?
How can we better understand the public health impacts of aflatoxins?

Polly Ericksen: Vulnerability and risk in drylands

Polly Ericksen (USA) leads drylands research at ILRI and for the CGIAR Research Program on Drylands Systems in East and Southern Africa, where, in the coming years, the program aims to assist 20 million people and mitigate land degradation over some 600,000 square kilometres. That CGIAR research program as a whole is led by the International Centre for Agricultural Research in the Dry Areas (ICARDA), Syria. Ericksen also leads a Technical Consortium for Ending Drought Emergencies and Building Resilience to Drought in the Horn of Africa. Her broad expertise includes food systems, ecosystem services and adaptations to climate change by poor agricultural and pastoral societies.

Questions Ericksen will address in ILRI’s side event are:
How can commercial pastoral livestock production lead to growth in risk-prone drylands?
Is there a long-term role for livestock insurance in pastoral production systems?

Iain Wright, Alan Duncan and Michael Blümmel: The biomass crisis in intensifying smallholder systems

Iain Wright (UK) is ILRI director general’s representative in Ethiopia and head of ILRI’s Addis Ababa campus, where over 300 staff are located. He also directs ILRI’s Animal Science for Sustainable Productivity program, a USD15-million global program working to increase the productivity of livestock systems in developing countries through high-quality animal science (breeding, nutrition and animal health) and livestock systems research. Before this, Wright served as director of ILRI’s People, Livestock and the Environment theme. And before that, from 2006 to 2011, he was ILRI’s regional representative for Asia, based in New Delhi and coordinating ILRI’s activities in South, Southeast Asia and East Asia. Wright has a PhD in animal nutrition. Before joining ILRI, he managed several research programs at the Macaulay Institute, in Scotland.

Alan Duncan (UK) is an ILRI livestock feed specialist and joint leader of the Nile Basin Development Challenge Programme. Duncan joined ILRI in 2007, also coming from Scotland’s Macaulay Institute. Duncan has a technical background in livestock nutrition but in recent years has been researching institutional barriers to feed improvement among smallholders. He also works on livestock-water interactions, which are a key issue in Ethiopia, where he is based, particularly in relation to the competition for water occurring between the growing of livestock feed and that of staple crops. Duncan manages a range of research-for-development projects and acts as ILRI’s focal point for the CGIAR Research Program on Integrated Systems for the Humid Tropics, which is led by the International Institute of Tropical Agriculture (IITA), Nigeria.

Michael Blümmel (Germany) is an ILRI animal nutritionist with PhD (1994) and Habilitation (2004) degrees from the University of Hohenheim, in Germany. He has more than 20 years of experience in research, teaching and development in Europe, the US, Africa and Asia. Blümmel’s major research interests include feeding and feed resourcing at the interface of positive and negative effects from livestock, multi-dimensional crop improvement concomitantly to improve food, feed and fodder traits in new crop cultivars, and optimization of locally available feed resources through small business enterprises around decentralized feed processing.

A question they will address in ILRI’s side event is:
What are the options for sustainable intensification through livestock feeding?

Ethel Makila: Mobilizing biosciences for a food-secure Africa

Ethel Makila (Kenya) is ILRI communications officer for the Biosciences eastern and Central Africa-ILRI Hub. She is a graphic designer expert in development communication, media and education. At the BecA-ILRI Hub, she is responsible for increasing awareness of the Hub’s activities, facilities and impacts among African farmers, research institutes, government departments, Pan-African organizations and the international donor and research communities.

Questions Makila will address in ILRI’s side event are:
How can we build bio-sciences capacity in Africa to move from research results to development impacts?
How can we keep the BecA-ILRI Hub relevant to the research needs and context of African scientists?

Suzanne Bertrand: Vaccine biosciences

Suzanne Bertrand (Canada) is ILRI deputy director general for research-biosciences. With a PhD in plant molecular biology from Laval University, Bertrand began her career as a scientist with Agri-Food Canada, working on forage plants. Her focus shifted rapidly from laboratory-based research to application of modern agri-technology in the developing world. Her overseas assignments included spells in the People’s Republic of China and Tunisia. She spent six years in the USA, first as research assistant professor at North Carolina State University, and then as a founding principal for a biotechnology start-up company. She then joined Livestock Improvement (LIC), a large dairy breeding enterprise in New Zealand, where she managed LIC’s Research and Development Group, delivering science-based solutions in the areas of genomics, reproductive health, animal evaluation and commercialization to the dairy sector. In 2008, Bertrand became director, International Linkages for the Ministry of Research, Science and Technology in New Zealand. She was later chief executive officer for NZBIO, an NGO representing the interests and supporting growth of the bioscience sector in New Zealand.

Questions Bertrand will address in ILRI’s side event are:
How do we stimulate and sustain an African vaccine R&D pathway to achieve impact?
How can we grow a biotech and vaccine manufacturing sector in Africa?

Find more information about AASW6, including a full agenda, and follow the hashtag #AASW6 on social media.

Full list of ILRI participants at AASW6

Jimmy Smith, director general, based at ILRI’s headquarters, in Nairobi, Kenya
John McIntire, deputy director general-Integrated Sciences, Nairobi
Suzanne Bertrand, deputy director general—Biosciences, Nairobi
Shirley Tarawali, director of Institutional Planning and Partnerships, Nairobi
Iain Wright, director of ILRI Animal Sciences for Sustainable Agriculture Program, based at ILRI’s second principal campus, in Addis Ababa, Ethiopia
Abdou Fall, ILRI regional representative and manager of conservation of West African livestock genetic resources project, based in Senegal
Iheanacho (Acho) Okike, manages project of the CGIAR Research Program on Livestock and Fish, based in Ibadan, Nigeria
Appolinaire Djikeng, director of the Biosciences eastern and Central Africa-ILRI Hub, Nairobi
Iddo Dror, head of ILRI Capacity Development, Nairobi
Delia Grace, leads ILRI Food Safety and Zoonosis program and also an ‘Agriculture-Associate Diseases’ component of CRP on Agriculture for Nutrition and Health, Nairobi
Joy Appiah, former student in ILRI Safe Food, Fair Food project; ILRI is supporting his participation at AASW6; he is now at the University of Ghana
Polly Ericksen, leads dryands research within ILRI Livestock Systems and Environment program, serves as ILRI focal point for two CGIAR research programs—on Climate Change, Agriculture and Food Security and Dryland Systems—and leads a Technical Consortium for Building Resilience to Drought in the Horn of Africa, based in Nairobi
Katie Downie, coordinator of the Technical Consortium for Building Resilience to Drought in the Horn of AfricaHorn of Africa, Nairobi
Alan Duncan, leads feed innovations research within ILRI Animal Sciences for Sustainable Agriculture program and serves as ILRI focal point for the CGIAR Research Program on the HumidTropics, Addis Ababa
Michael Blümmel, leads feed resources research within ILRI Animal Sciences for Sustainable Agriculture program, based at ICRISAT, in Hyderabad, India
Allan Liavoga, deputy program manager of Bio-Innovate, Nairobi
Dolapo Enahoro, agricultural economist within ILRI Policy, Trade and Value Chains program, based in Accra

Communications support

Ewen LeBorgne, ILRI knowledge management and communications specialist; is facilitating ILRI’s side session at AASW6 on 15 Jul; based in Addis Ababa
Muthoni Njiru, ILRI communications officer in ILRI Public Awareness unit: overseeing media relations, exhibit materials, video reporting at AASW6; Nairobi
Paul Karaimu, ILRI communications writer/editor in ILRI Public Awareness unit: overseeing blogging, photography, video reporting at AASW6; Nairobi
Ethel Makila, ILRI communications specialist for the BecA-ILRI Hub, Nairobi
Albert Mwangi, ILRI communications specialist for Bio-Innovate, Nairobi

plus

Cheikh Ly, ILRI board member, from Senegal, veterinary expert at FAO, based in Accra, Ghana
Lindiwe Majele Sibanda, ILRI board chair, from Zimbabwe, livestock scientist, agricultural policy thinker, and CEO and head of mission of the Food, Agriculture and Natural Resources Policy Analysis Network (FANRPAN), based in Pretoria, South Africa

New advances in the battle against a major disease threat to cattle and people in Africa

Posted on May 1, 2013 by Susan MacMillan

An 8-month old cloned Boran calf named Tumaini (meaning ‘hope’ in Kiswahili), on the left, is part of a long-term ILRI research project to develop cattle for Africa that are genetically resistant to trypanosomiasis (photo credit: ILRI/Paul Karaimu).

The International Livestock Research Institute (ILRI), a member of the CGIAR Consortium, is a non-profit organization based in Africa. ILRI’s mission is to use the best and safest livestock science available to confront poverty, hunger, and disease in the developing world, where livestock provide livelihoods and food for hundreds of millions of people.

One of ILRI’s most important priorities today is to help poor livestock keepers in Africa deal with the constant threat of a devastating disease called trypanosomiasis. This disease is arguably Africa’s most important livestock disease, wasting and killing cattle, commonly the most important asset of poor households. The human form of the disease is called sleeping sickness, which afflicts tens of thousands of people every year, killing many of them, and putting tens of millions more people at risk.

As part of ILRI’s comprehensive fight against trypanosomiasis, the institute is now in the very early stages of a project to develop disease-resistant cattle, which could save the lives of livestock and people both. Thus far, ILRI and its partners have taken a preliminary step in the process, which involved successfully cloning a male calf from one of East Africa’s most important cattle breeds, the Boran. The calf is healthy and is being raised at ILRI’s research facilities in Kenya.

A next step is to develop a new Boran clone modified with a gene that naturally confers resistance to the disease. This involves using a synthetic copy of a gene sequence originally identified in baboons that should protect cattle against this devastating disease.

A final step will be to use these disease-resistant cattle in breeding schemes that will provide African countries with another option in their fight against trypanosomiasis.

This research potentially offers a reliable, self-sustaining and cost-effective way of protecting tens of millions of African cattle against disease and untimely death, as well as dramatically reducing poverty across Africa. By reducing the reservoir of pathogens, this should also help to save thousands of human lives each year.

It could take up to two decades to develop disease-resistant cattle herds for Africa. ILRI and its partners are also continuing to pursue other options for fighting trypanosomiasis, such as rationale drug treatment and integrated disease control methods.

For ILRI, public safety and animal welfare are paramount; this means working with all the relevant Kenyan and international regulatory authorities to ensure that the highest bio-safety standards are always employed. In line with its commitment to transparency, ILRI places all of its research results in the public domain.

ILRI is working with a team that includes scientists from New York University, along with experts from the Roslin Institute in Scotland, and Michigan State University in the USA. The fundamental research aspects of this project are being funded by the US National Science Foundation.

For further information, see:
ILRI website:
https://www.ilri.org/breadtrypanosome

National Science Foundation:
www.nsf.gov/news/news_summ.jsp?cntn_id=116932

2009 paper published in the Proceedings of the National Academy of Sciences (USA) on original breakthrough in this research project:
http://dx.doi.org/10.1073%2Fpnas.0905669106

Or contact one of the following people:

Jimmy Smith
ILRI Director General
j.smith@cgiar.org

Suzanne Bertrand
ILRI Deputy Director General for Biosciences
s.bertrand@cgiar.org

Steve Kemp
Leader of ILRI’s research on this topic
s.kemp@cgiar.org

About ILRI: better lives through livestock
www.ilri.org
The International Livestock Research Institute (ILRI) works with partners worldwide to enhance the roles that livestock play in food security and poverty alleviation, principally in Africa and Asia. The outcomes of these research partnerships help people in developing countries keep their farm animals alive and productive, increase and sustain their livestock and farm productivity, find profitable markets for their animal products, and reduce the risk of livestock-related diseases. ILRI is a not-for-profit institution with a staff of about 600 and, in 2012, an operating budget of about USD 60 million. A member of the CGIAR Consortium working for a food-secure future, ILRI has its headquarters in Nairobi, Kenya, a principal campus in Addis Ababa, Ethiopia, and offices in other countries in East, West and Southern Africa and in South, Southeast and East Asia.

About CGIAR: working for a food-secure future
www.cgiar.org
CGIAR is a global partnership that unites organizations engaged in research for a food-secure future. It is carried out by 15 centres that are members of the CGIAR Consortium and conducted in close collaboration with hundreds of partner organizations, including national and regional research institutes, civil society organizations, academia and the private sector. The CGIAR’s 8,000 scientists and staff work in the developing world to reduce rural poverty, increase food security, improve human health and nutrition, and ensure more sustainable management of natural resources. With unparalleled research infrastructure and dynamic networks across the globe, and maintaining the world’s most comprehensive collections of genetic resources, CGIAR is the only institution with a clear mandate on science and technology development for the eradication of hunger and poverty at the global level.

Alliance meeting this week to battle global ‘goat plague’

Posted on April 29, 2013 by Susan MacMillan

The PPR virus, commonly known as goat plague, swept across southern Ethiopia and northern Kenya in 2008; Mohammed Noor lost 20 goats in the just one week and wondered how he would provide for his family (photo on Flickr by EC/ECHO/Daniel Dickinson).

Assembling for two days this week (29–30 Apr 2013) in Nairobi, Kenya, are members of a global alliance against ‘peste des petits ruminants’, abbreviated as ‘PPR’ and also known as ‘goat plague’ and ‘ovine rinderpest’.

Co-hosting this second meeting of the Global Peste de Petits Ruminants (PPR) Research Alliance (hereafter referred to as GPRA) are the International Livestock Research Institute (ILRI), which is headquartered in Nairobi; the Biosciences eastern and central Africa-iLRI hub (BecA-ILRI Hub), hosted and managed by ILRI; the African Union-Interafrican Bureau for Animal Resources (AU-IBAR), also based in Nairobi; and the Australian Agency for International Development (AusAID).

Among the 70 or so people attending are representatives from the Bill & Melinda Gates Foundation (BMGF, Yi Cao), the Global Alliance for Livestock Veterinary Medicines (GALVMed, Bapti Dungu), the International Atomic Energy Agency (IAEA, Adama Diallo), the Pan African Veterinary Vaccine Centre (PANVAC), the Royal Veterinary College of the University of London Vet School (RVC), the United Nations Food and Agriculture Organization (FAO, Vincent Martin and Robert Allport, among others), the World Organisation for Animal Health (OIE, Jemi Domenech and Walter Masiga) and a range of national research institutions from developing countries where the disease is endemic.

What’s this alliance all about?
The GPRA is a participant-owned network of researchers and development professionals with an interest in the progressive control of PPR. The GPRA was inaugurated in 2012 at a meeting in London. GPRA aims to provide scientific and technical knowledge towards methods for the detection, control and eradication of PPR that are economically viable, socially practical and environmentally friendly.

Why, and how much, does PPR matter?
Infectious diseases remain the major limitation to livestock production globally and are a particular scourge in the developing world, where most of the world’s livestock are raised. Diseases not only kill farm animals but also cause production losses and hinder access to potentially high-value international livestock markets.

PPR, an infectious viral disease of sheep and goats, poses a major threat to the livelihoods of smallholder farmers in Africa as well as the Middle East and India. The disease is highly contagious, and has roughly an 80 per cent mortality rate in acute cases.

The impacts of PPR, which is closely related to rinderpest in cattle, have been expanding in recent years. At least 15 million sheep and goats are at risk of death from the disease in Kenya alone and the estimated economic impact of current PPR outbreaks—including production losses and disease control costs for Africa—is more than US$147 million per year. A recent outbreak of PPR in the Marakwet and Baringo districts of Kenya destroyed more than 2000 herds, with the disease spreading in days and farmers losing some KShs6 million (about US$70,000) to the disease over about three months.

PPR is probably the most important killer of small ruminant populations in affected areas and some 65 per cent of the global small ruminant population is at risk from PPR.

Increasing interest in tackling PPR
Over the last several years, international experts and national authorities have both been increasingly prioritizing the progressive control of PPR, with the first phase designed to contribute to the long-term goal of eradication. Donor interest in this research and development area quickly ramped up over the past year. A current AusAID-funded project being conducted under a partnership between the BecA-ILRI Hub and Australia’s Commonwealth Scientific, Industrial and Research Organisation (CSIRO) has supported development of a thermostable vaccine now being piloted in vaccination campaigns in Sudan and Uganda, with similar work proposed for Ethiopia.

Collins Owino, an ILRI research technician working on vaccines and diagnostics in the peste des petits ruminants (PPR) project (photo credit: ILRI/Evelyn Katingi).

Need for coordinated and progressive control of PPR
There is a growing recognition of the need for, and potential benefits of, a coordinated approach to the progressive control of PPR. The disease is now one of the high priorities of AU-IBAR, FAO and OIE, all of which have strong networks and expertise to offer the alliance. The role of the Global PPR Research Alliance as a network of research and development organizations is to develop a coordinated strategy to contribute to the progressive control of PPR.

The Australian Government, together with AU-IBAR and ILRI, is supporting the second meeting of the GPRA to advance with many other stakeholders progressive global control of PPR, particularly through collaborative research. The GPRA supports the sharing of relevant information and results, the establishment of productive working relationships among stakeholders, the establishment of research and development projects of interest to some or all members, and the closer linking of strategic plans of all stakeholders in better control of this disease.

Is progressive eradication of PPR possible?
Wide calls for PPR’s progressive global eradication cite the following factors supporting this goal:

The close relationship of PPR/’goat plague’ with the recently eradicated ‘cattle plague’ known as ‘rinderpest’ (rinderpest was only the second infectious disease, and the first veterinary disease, to be eradicated from the globe)
The availability of effective vaccines against PPR
The development of heat-stable PPR vaccines, following the same procedures that were so effective in developing a heat-stable rinderpest vaccine
The opportunity to increase focus on Africa and Asia’s small ruminants, which are of critical importance to the livelihoods of rural smallholder and pastoralist communities in many of the world’s poorest countries
The existence of vaccines and diagnostics considered sufficient to initiate the program; the current vaccines (based on the strain Nigeria 75/1) are safe, efficacious and provide life-long immunity.

More about the AusAID-funded PPR project at the BecA-ILRI Hub
The Australian Government via AusAID has funded development at ILRI of thermostable formulations of the PPR vaccine that provide a level of stability in the field as high as that demonstrated in the vaccine used to eradicate rinderpest. The project team has demonstrated that the PPR vaccine can be stored without refrigeration for extended periods of time without significant loss in viability. This is a crucial and significant success. Under the guidance of ILRI senior scientist Jeff Mariner and with the assistance of Australia’s CSIRO and BecA-ILRI Hub staff, the project team have developed strong links with AU-IBAR’s Henry Wamwayi, a senior member of his organization seconded to the PPR project.

ILRI veterinary epidemiologist Jeff Mariner presenting lessons learned from work to eradicate rinderpest at a meeting of the World Animal Health Organisation (OIE) (photo credit: OIE).

Next steps
The project has built on lessons learned from the recent global eradication of rinderpest, which depended on two equally important breakthroughs for its success: development of an effective thermostable vaccine and effective vaccine delivery networks in remote as well as other regions. The next 12 months of the PPR research project will focus on testing the vaccine and delivery strategies in South Sudan and Uganda. Staff will assess in the field just how effective the vaccine is in controlling PPR infections. They’ll also investigate some practical incentives for encouraging livestock owners and livestock service delivery personnel to participation in PPR control programs. And they’ll look into ways to build and enhance public-private community partnerships to deliver the PPR vaccine.

Read more in the ILRI News Blog and science journals about the close connections between the eradication of rinderpest and this new battle against PPR—and the role of ILRI’s Jeff Mariner in development of thermostable vaccines necessary to win the battle against both diseases.

Rinderpest: Scourge of pastoralists defeated, at long last, by pastoralists, 18 Sep 2012.

New analysis in ‘Science’ tells how the world eradicated deadliest cattle plague from the face of the earth, 13 Sep 2012.

Goat plague next target of veterinary authorities now that cattle plague has been eradicated, 4 Jul 2011.

Deadly rinderpest virus today declared eradicated from the earth—’greatest achievement in veterinary medicine’, 28 Jun 2011.

Experts take up two new director positions at ILRI, world’s leading pro-poor livestock research institute

Posted on January 10, 2013 by Susan MacMillan

ILRI’s new deputy director of research in integrated systems John McIntire.

The International Livestock Research Institute (ILRI) last November appointed two new deputy director generals of research at the institute. American John McIntire, formerly of the World Bank, will direct research on integrated livestock systems at ILRI while Suzanne Bertrand, a Canadian who has been working in the private sector in New Zealand, takes on directorship of ILRI’s biosciences research. This month they took up their new positions, where they also serve on ILRI’s senior management team, reporting to ILRI director general Jimmy Smith.

John McIntire, ILRI deputy director general for integrated systems research
John McIntire is a native Californian who graduated from Occidental College, where he was a member of the regional champion cross-country team, in 1972 with a BA in history. He worked in a pharmaceuticals factory until 1975, when he began graduate studies at the Fletcher School at Tufts University. In 1980, Fletcher awarded him a PhD in agricultural economics, based in part on fieldwork he had conducted near Segou, in central Mali, from 1977 to 1978. That work, done in collaboration with the West African Rice Development Association (now AfricaRice) and the Malian national research program, was one of the original farm-level studies of smallholder crop production done anywhere in francophone Africa and one of the first to study competition between rainfed and irrigated crops.

After receiving his PhD, McIntire took up a job as research associate at the International Food Policy Research Institute (IFPRI), in Washington, DC, where he published Food Security in the Sahel: Variable Import Levy, Grain Reserves and Foreign Exchange Assistance (1981). This report was one of the first papers to use a quantitative model of food supply and demand to investigate policies for improving food security in West Africa. In 1980, McIntire was appointed principal economist in the West Africa Program of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), where he was based at the Kamboinse Research Station, near Ouagadougou, Burkina Faso. There he worked to identify constraints to improving millet and sorghum production in the sub-humid and semi-arid tropics of Burkina Faso, publishing work on village surveys, intercropping and animal traction. In 1981, he moved with ICRISAT to Niger, where he helped establish the ICRISAT Sahelian Centre at Sadore and conducted village-level studies on farmer-managed experiments with new millet-producing techniques involving improved cultivars, intercropping and mineral fertilizers.

McIntire left ICRISAT and Niger in 1984 to take up a position as principal economist at the International Livestock Centre for Africa (ILCA), one of ILRI’s two predecessors, in Addis Ababa, Ethiopia. While at ILCA, he worked on the economics of ILCA’s priority setting, trypanotolerance (genetic resistance to the disease African animal trypanosomosis), smallholder cattle fattening, crop residue management, alley farming and crop-livestock integration. Based on his work at ILCA and ICRISAT, he published Crop Livestock Integration in Sub-Saharan Africa (1992), with Daniel Bourzat and Prabhu Pingali, a book still widely cited 20 years later.

McIntire joined the World Bank in 1989, where he worked until his retirement in 2011. There he developed and managed a National Agricultural Technology Program for Mexico, which was, at the time, the largest Bank investment in national agricultural research in the world. He later worked as country economist for Côte d’Ivoire, where he was instrumental in the reform of the national cocoa marketing institution and in restructuring that country’s international debt as part of the HIPC (Heavily Indebted Poor Countries) Initiative. From 2000 to 2004, he was World Bank country director for Senegal, the Gambia, Cape Verde and Guinea. From 2004 to 2007, he served as director for Agricultural, Environmental and Social Development in the Africa Region of the World Bank. His final Bank assignment was country director for Tanzania, Uganda and Burundi, where he managed a team of some 200 people that delivered one of the largest IDA (International Development Association) programs in the world. In 2011, he was the second person to receive both the Bank’s ‘Good Manager Award’ and ‘Green Award for Environmental Leadership’, the latter notably for his work in defending Serengeti National Park.

ILRI’s new deputy director of research in biosciences Suzanne Bertrand.

Suzanne Bertrand, ILRI deputy director general for biosciences research
Suzanne Bertrand’s background is a unique mix of science and managerial roles in government, academia and the private sector, with long interest and hands-on experience in international development. She has expertise in managing stakeholder and client relationships and in building project engagement strategies.

Bertrand earned a PhD in plant molecular biology at Laval University (French: Université Laval), in Canada’s Quebec Province and began her career as a scientist with Agri-Food Canada, working on forage plants. Her focus shifted rapidly from laboratory-based research to the application of modern agri-technology in the developing world. Her first overseas assignment was as a consulting plant physiologist for a Gansu Forest Nursery Project in the People’s Republic of China, funded by the Canadian International Development Agency; Bertrand served as director of this project for its last three years. She then went to North Africa, again as project director, to manage the installation and start-up of five tree nurseries in Tunisia, a project funded by the Nordic Development Bank and World Bank.

Bertrand spent six years in the USA, first as research assistant professor at North Carolina State University and then as a founding principal for a biotechnology start-up company. She was then recruited as group manager for innovation with Livestock Improvement Corporation (LIC), a large dairy breeding enterprise in New Zealand, where she managed LIC’s Research and Development Group, delivering science-based solutions in the areas of genomics, reproductive health, animal evaluation and commercialization to the dairy sector.

In 2008, Bertrand became director of international linkages for the New Zealand Ministry of Research, Science and Technology. In this role, she established an overarching framework for the ministry’s external engagement and developed an International Linkages Strategy for New Zealand science. She was most recently chief executive officer for NZBIO, an NGO representing the interests and supporting the growth of the bioscience sector in New Zealand. Membership in NZBIO spans the spectrum of agbiotech, human health, industrial, environmental and food bioscience, from start-up companies to Crown research institutes and universities to large corporates and multinationals.

Bertrand has a lifelong interest in fine cuisine, art history, all things gardening, and travel.

A few of our favourite (missed) livestock presentations in 2012

Posted on January 3, 2013 by Susan MacMillan

Here, for your New Year’s reading/viewing pleasure, are 20 slide presentations on 12 topics made by staff of the International Livestock Research Institute (ILRI) in 2012 that we missed reporting on here (at the ILRI News Blog) during the year.

Happy reading and Happy New Year!

1 LIVESTOCK RESEARCH FOR FOR DEVELOPMENT

>>> Sustainable and Productive Farming Systems: The Livestock Sector
Jimmy Smith
International Conference on Food Security in Africa: Bridging Research and Practice, Sydney, Australia
29-30 Nov 2012; posted on ILRI Slideshare 27 Nov 2012; 426 views.

Excerpts:
A balanced diet for 9 billion: Importance of livestock
•  Enough food: much of the world’s meat, milk and cereals comes from developing-country livestock based systems
•  Wholesome food: Small amounts of livestock products – huge impact on cognitive development, immunity and well being
•  Livelihoods: 80% of the poor in Africa keep livestock, which contribute at least one-third of the annual income.
The role of women in raising animals, processing and 3 selling their products is essential.

Key messages: opportunities
•  Livestock for nutrition and food security:
– Direct – 17% global kilocalories; 33% protein; contribute food for 830 million food insecure.
Demand for all livestock products will rise by more than 100% in the next 30 years, poultry especially so (170% in Africa)
– Indirect – livelihoods for almost 1 billion, two thirds women
•  Small-scale crop livestock systems (less than 2ha; 2 TLU) provide 50–75% total livestock and staple food production in Africa and Asia
and provide the greatest opportunity for research to impact on a trajectory of growth that is inclusive –
equitable, economically and environmentally sustainable.

>>> The Global Livestock Agenda: Opportunities and Challenges
Jimmy Smith
15th AAAP [Asian-Australasian Association of Animal Production] Animal Science Congress, Bangkok,Thailand
26–30 Nov 2012; posted on ILRI Slideshare 27 Nov 2012; 1,650 views

Excerpt:
Livestock and global development challenges
•  Feeding the world
– Livestock provide 58 million tonnes of protein annually and 17% of the global kilocalories.
•  Removing poverty
– Almost 1 billion people rely on livestock for livelihoods
•  Managing the environment
– Livestock contribute 14–18% anthropogenic greenhouse gas emissions, use 30% of the freshwater used for agriculture and 30% of the ice free land
– Transition of livestock systems
– Huge opportunity to impact on future environment
•  Improving human health
– Zoonoses and contaminated animal-source foods
– Malnutrition and obesity

>>> Meat and Veg: Livestock and Vegetable Researchers Are Natural,
High-value, Partners in Work for the Well-being of the World’s Poor
Jimmy Smith
World Vegetable Center, Taiwan
18 Nov 2012; posted on ILRI Slideshare 27 Nov 2012; 294 views.

Excerpts:
Livestock and vegetables suit an urbanizing, warming world
Smallholder livestock and vegetable production offers similar opportunities:
•  Nutritious foods for the malnourished.
•  Market opportunities to meet high urban demand.
•  Income opportunities for women and youth.
•  Expands household incomes.
•  Generates jobs.
•  Makes use of organic urban waste and wastewater.
•  Can be considered ‘organic’ and supplied to niche markets.

Opportunities for livestock & vegetable research
Research is needed on:
•  Ways to manage the perishable nature of these products.
•  Innovative technological and institutional solutions for food safety and public health problems that suit developing countries.
•  Processes, regulations and institutional arrangements regarding use of banned or inappropriate pesticides,
polluted water or wastewater for irrigation, and untreated sewage sludge for fertilizer.
•  Innovative mechanisms that will ensure access by the poor to these growing markets.
•  Ways to include small-scale producers in markets demanding
increasingly stringent food quality, safety and uniformity standards.

>>> The African Livestock Sector:
A Research View of Priorities and Strategies
Jimmy Smith
6th Meeting of the CGIAR Independent Science and Partnership Council, Addis Ababa, Ethiopia
26−29 Sep 2012; posted on ILRI Slideshare 25 Sep 2012; 4,227 views.

Excerpts:
Livestock for nutrition
• In developing countries, livestock contribute 6−36% of protein and 2−12% of calories.
• Livestock provide food for at least 830 million food-insecure people.
• Small amounts of animal-source foods have large benefits on child growth and cognition and on pregnancy outcomes.
• A small number of countries bear most of the burden of malnutrition (India, Ethiopia, Nigeria−36% burden).

Smallholder competitiveness
Ruminant production
• Underused local feed resources and family labour give small-scale ruminant producers a comparative advantage over larger producers, who buy these.
Dairy production
• Above-normal profits of 19−28% of revenue are found in three levels of intensification of dairy production systems.
• Non-market benefits – finance, insurance, manure, traction – add 16−21% on top of cash revenue.
• Dairy production across sites in Asia, Africa, South America showed few economies of scale until opportunity costs of labour rose.
• Nos. of African smallholders still growing strongly.
Small ruminant production
• Production still dominated by poor rural livestock keepers, incl. women.
• Peri-urban fattening adds value.

>>> The CGIAR Research Program on Livestock and Fish and its Synergies
with the CGIAR Research Program on Agriculture for Nutrition and Health
Delia Grace and Tom Randolph
Third annual conference on Agricultural Research for Development: Innovations and Incentives, Uppsala, Sweden
26–27 Sep 2012; posted on ILRI Slideshare 13 Oct 2012; 468 views.

Excerpts:
Lessons around innovations and incentives
• FAILURE IS GETTING EASIER TO PREDICT – but not necessarily success
• INNOVATIONS ARE THE LEVER – but often succeed in the project context but not in the real world
• PICKING WINNERS IS WISE BUT PORTFOLIO SHOULD BE WIDER– strong markets and growing sectors drive uptake
• INCENTIVES ARE CENTRAL: value chain actors need to capture visible benefits
• POLICY: not creating enabling policy so much as stopping the dead hand of disabling policy and predatory policy implementers
‘Think like a systemicist, act like a reductionist.’

>>> The Production and Consumption of Livestock Products
in Developing Countries: Issues Facing the World’s Poor
Nancy Johnson, Jimmy Smith, Mario Herrero, Shirley Tarawali, Susan MacMillan, and Delia Grace
Farm Animal Integrated Research 2012 Conference, Washington DC, USA
4–6 Mar 2012; posted on ILRI Slideshare 7 Mar 2012; 1,108 views.

Excerpts:
The rising demand for livestock foods in poor countries presents
– Opportunities
• Pathway out of poverty and malnutrition
• Less vulnerability in drylands
• Sustainable mixed systems
– Threats
• Environmental degradation at local and global scales
• Greater risk of disease and poor health
• Greater risk of conflict and inequity

• Key issues for decision makers
– appreciation of the vast divide in livestock production between rich and poor countries
– intimate understanding of the specific local context for specific livestock value chains
– reliable evidence-based assessments of the hard trade-offs involved in adopting any given approach to livestock development

• Institutional innovations as important as technological/biological innovations in charting the best ways forward
– Organization within the sector
– Managing trade offs at multiple scales

2 LIVESTOCK FEEDS

>>> Livestock feeds in the CGIAR Research Programs
Alan Duncan
Food and Agricultural Organization of the United Nations (FAO) West Africa Regional Workshop on Crop Residues, Dakar, Senegal
10–13 Dec 2012; posted on ILRI Slideshare on 18 Dec 2012; 3,437 views.

>>> Biomass Pressures in Mixed Farms: Implications for Livelihoods
and Ecosystems Services in South Asia & Sub-Saharan Africa
Diego Valbuena, Olaf Erenstein, Sabine Homann-Kee Tui, Tahirou Abdoulaye, Alan Duncan, Bruno Gérard, and Nils Teufel
Planet Under Pressure Conference, London, UK
26-29 Mar 2012; posted on ILRI Slideshare 27 Mar 2012; 1,999 views.

3 LIVESTOCK IN INDIA

>>> Assessing the Potential to Change Partners’ Knowledge,
Attitude and Practices on Sustainable Livestock Husbandry in India
Sapna Jarial, Harrison Rware, Pamela Pali, Jane Poole and V Padmakumar
International Symposium on Agricultural Communication and
Sustainable Rural Development, Pantnagar, Uttarkhand, India
22–24 Nov 2012; posted on ILRI Slideshare 30 Nov 2012; 516 views.

Excerpt:
Introduction to ELKS
• ‘Enhancing Livelihoods Through Livestock Knowledge Systems’ (ELKS) is an initiative
to put the accumulated knowledge of advanced livestock research directly to use
by disadvantaged livestock rearing communities in rural India.
• ELKS provides research support to Sir Ratan Tata Trust and its development partners
to address technological, institutional and policy gaps.

4 AGRICULTURAL R4D IN THE HORN OF AFRICA

>>> Introducing the Technical Consortium
for Building Resilience to Drought in the Horn of Africa
Polly Ericksen, Mohamed Manssouri and Katie Downie
Global Alliance on Drought Resilience and Growth, Addis Ababa, Ethiopia
5 Nov 2012; posted on ILRI Slideshare 21 Dec 2012; 8,003 views.

Excerpts:
What is the Technical Consortium?
• A joint CGIAR-FAO [Food and Agriculture Organization of the United Nations] initiative,
with ILRI representing the CGIAR Centres and the FAO Investment Centre representing FAO.
• ILRI hosts the Coordinator on behalf of the CGIAR.
• Funded initially by USAID [United State Agency for International Development] for 18 months –
this is envisioned as a longer term initiative, complementing the implementation of investment plans
in the region and harnessing, developing and applying innovation and research to enhance resilience.
• An innovative partnersh–ip linking demand-driven research sustainable action for development.

What is the purpose of the Technical Consortium?
• To provide technical and analytical support to IGAD [Inter-governmental Authority on Development]
and its member countries to design and implement the CPPs [Country Programming Papers]
and the RPF [Regional Programming Framework], within the scope of
the IGAD Drought Disaster Resilience and Sustainability Initiative (IDDRSI).
• To provide support to IGAD and its member countries to develop regional and national
resilience-enhancing investment programmes for the long term development of ASALs [arid and semi-arid lands].
• To harness CGIAR research, FAO and others’ knowledge on drought resilience and bring it to bear on investments and policies.

5 LIVESTOCK AND FOOD/NUTRITIONAL SECURITY

>>> Mobilizing AR4D Partnerships to Improve
Access to Critical Animal-source Foods
Tom Randolph
Pre-conference meeting of the second Global Conference for Agricultural Research for Development (GCARD2), Punta de Este, Uruguay
27 Oct 2012; posted on ILRI Slideshare 29 Oct 2012; 385 views.

Excerpts:
The challenge
• Can research accelerate livestock and aquaculture development to benefit the poor?
– Mixed record to date
– Systematic under-investment
– Also related to our research-for-development model?
• Focus of new CGIAR Research Program
– Increase productivity of small-scale systems
> ‘by the poor’ for poverty reduction
> ‘for the poor’ for food security

Correcting perceptions
1. Animal-source foods are a luxury and bad for health, so should not promote
2. Small-scale production and marketing systems are disappearing; sector is quickly industrializing
3. Livestock and aquaculture development will have negative environmental impacts

Our underlying hypothesis
• Livestock and Blue Revolutions: accelerating demand in developing countries as urbanization and incomes rise
• Industrial systems will provide a large part of the needed increase in supply to cities and the better-off in some places
• But the poor will often continue to rely on small-scale production and marketing systems
• If able to respond, they could contribute, both increasing supplies and reducing poverty
. . . and better manage the transition for many smallholder households.

6 LIVESTOCK INSURANCE

>>> Index-Based Livestock Insurance:
Protecting Pastoralists against Drought-related Livestock Mortality
Andrew Mude
World Food Prize ‘Feed the Future’ event, Des Moines, USA
18 Oct 2012; posted on ILRI Slideshare 22 Oct 2012; 576 views.

Excerpts:
Index-Based Livestock Insurance
• An innovative insurance scheme designed to protect pastoralists against the risk of drought-related livestock deaths
• Based on satellite data on forage availability (NDVI), this insurance pays out when forage scarcity is predicted to cause livestock deaths in an area.
• IBLI pilot first launched in northern Kenya in Jan 2010. Sold commercially by local insurance company UAP with reinsurance from Swiss Re
• Ethiopia pilot launched in Aug 2012.

Why IBLI? Social and Economic Welfare Potential
An effective IBLI program can:
• Prevent downward slide of vulnerable populations
• Stabilize expectations & crowd-in investment by the poor
• Induce financial deepening by crowding-in credit S & D
• Reinforce existing social insurance mechanisms

Determinants of IBLI Success
DEMONSTRATE WELFARE IMPACTS
• 33% drop in households employing hunger strategies
• 50% drop in distress sales of assets
• 33% drop in food aid reliance (aid traps)

7 LIVESTOCK-HUMAN (ZOONOTIC) DISEASES

>>> Lessons Learned from the Application of Outcome Mapping to
an IDRC EcoHealth Project: A Double-acting Participatory Process
K Tohtubtiang, R Asse, W Wisartsakul and J Gilbert
1st Pan Asia-Africa Monitoring and Evaluation Forum, Bangkok, Thailand
26–28 Nov 2012; posted on ILRI Slideshare 5 Dec 2012; 1,395 views.

Excerpt:
EcoZD Project Overview
Ecosystem Approaches to the Better Management of Zoonotic Emerging
Infectious Diseases in the Southeast Asia Region (EcoZD)
•  Funded by International Development Research Centre, Canada (IDRC)
•  5-year project implemented by International Livestock Research Institute (ILRI)
•  Goals: capacity building & evidence-based knowledge•  8 Research & outreach teams in 6 countries.

>>> Mapping the interface of poverty, emerging markets and zoonoses
Delia Grace
Ecohealth 2012 conference, Kunming, China
15–18 Oct 2012; posted on ILRI Slideshare 23 Nov 2012; 255 views.

Excerpt:
Impacts of zoonoses currently or in the last year
• 12% of animals have brucellosis, reducing production by 8%
• 10% of livestock in Africa have HAT, reducing their production by 15%
• 7% of livestock have TB, reducing their production by 6% and from 3–10% of human TB cases may be caused by zoonotic TB
• 17% of smallholder pigs have cysticercosis, reducing their value and creating the enormous burden of human cysticercosis
• 27% of livestock have bacterial food-borne disease, a major source of food contamination and illness in people
• 26% of livestock have leptospirosis, reducing production and acting as a reservoir for infection
• 25% of livestock have Q fever, and are a major source of infection of farmers and consumers.

>>> International Agricultural Research and Agricultural Associated Diseases
Delia Grace (ILRI) and John McDermott (IFPRI)
Workshop on Global Risk Forum at the One Health Summit 2012—
One Health–One Planet–One Future: Risks and Opportunities, Davos, Switzerland
19–22 Feb 2012; posted on ILRI Slideshare 5 Mar 2012; 529 views.

8 LIVESTOCK MEAT MARKETS IN AFRICA

>>> African Beef and Sheep Markets: Situation and Drivers
Derek Baker
South African National Beef and Sheep Conference, Pretoria, South Africa
21 Jun 2012; posted on ILRI Slideshare 24 Nov 2012; 189 views.

Excerpt:
African demand and consumption: looking to the future
• By 2050 Africa is estimated to become the largest world’s market in terms of pop: 27% of world’s population.
• Africa’s consumption of meat, milk and eggs will increase to 12, 15 and 11% resp. of global total (FAO, 2009)

9 KNOWLEDGE SHARING FOR LIVESTOCK DEVELOPMENT

>>> Open Knowledge Sharing to Support Learning in
Agricultural and Livestock Research for Development Projects
Peter Ballantyne
United States Agency for International Development-Technical and Operational Performance Support (USAID-TOPS) Program: Food Security and Nutrition Network East Africa Regional Knowledge Sharing Meeting, Addis Ababa, Ethiopia
11–13 Jun 2012; posted on ILRI Slideshare 11 Jun 2012; 2,220 views

10 LIVESTOCK AND GENDER ISSUES

>>> Strategy and Plan of Action for Mainstreaming Gender in ILRI
Jemimah Njuki
International Women’s Day, ILRI, Nairobi, Kenya
8 Mar 2012; posted on ILRI Slideshare 8 Mar 2012; 876 views.

11 AGRICULTURAL BIOSCIENCES HUB IN AFRICA

>>> Biosciences eastern and central Africa –
International Livestock Research Institute (BecA-ILRI) Hub:
Its Role in Enhancing Science and Technology Capacity in Africa
Appolinaire Djikeng
Annual Meeting of the American Association for the Advancement of Science (AAAS), Vancouver, Canada
16–20 Feb 2012; posted on ILRI Slideshare 20 Feb 2012; 2,405 views.

12 PASTORAL PAYMENTS FOR ENVIRONMENTAL SERVICES

>>> Review of Community Conservancies in Kenya
Mohammed Said, Philip Osano, Jan de Leeuw, Shem Kifugo, Dickson Kaelo, Claire Bedelian and Caroline Bosire
Workshop on Enabling Livestock-Based Economies in Kenya to Adapt to Climate Change:
A Review of PES from Wildlife Tourism as a Climate Change Adaptation Option, at ILRI, Nairobi, Kenya
15 Feb 2012; posted on ILRI Slideshare 27 Feb 2012; 762 views.

New vaccine launched today to protect Kenyan cattle against East Coast fever

Posted on December 7, 2012 by Susan MacMillan

Mrs Kivuti and her dairy cow in Kenya (on Flickr by Jeff Haskins).

Today is a red-letter day for livestock keepers in Kenya. A vaccine is being launched by the Kenya Department of Veterinary Services that will help Kenyan farmers protect their dairy and other cattle against East Cost fever. The launch is being held in Kenya’s Kitale town.

For four decades, the Nairobi-based International Livestock Research Institute (ILRI) and its predecessor (the International Laboratory for Research on Animal Diseases, ILRAD) have conducted research on the lethal tick-borne cattle disease known as East Coast fever. ILRI’s work has focused on developing a new-generation ‘subunit’ vaccine, comprising molecular components of the causative parasite, while also developing molecular tools to enhance the quality of an infection-and-treatment (ITM) immunization method, consisting of whole live parasites.

The ITM vaccine was developed first by the former East African Veterinary Research Organisation, at Muguga, Kenya, between 1967 and 1977, now known as the Veterinary Research Centre, which is part of the Kenya Agricultural Research Institute (KARI) and which has continued to refine the vaccine.

ILRI produced the first commercial batch of the ITM vaccine in the late 1990s, at the request of the Food and Agriculture Organization of the United Nations. A decade later, on request from regional stakeholders, ILRI produced a second batch, which is now being used in East Africa. ILRI and KARI also supported Kenya’s Director of Veterinary Services (DVS) in his department’s successful trials that have confirmed the safety and effectiveness of the ITM vaccine, thus making way for the launch of its national distribution today.

Two ILRI scientists, Phil Toye and Henry Kiara, that have been involved in this research for many years are attending the launch. They say that East Coast fever continues to cause major economic and social losses to families in eastern, central and southern Africa.

Of the 46 million cattle in this region almost half are at risk from this disease, say Toye and Kiara.

‘ILRI’s work has focused on better understanding of the biology of the parasite that causes the disease and the host immune responses to infection. While the ITM vaccine was developed in the early 1970s at Muguga, Kenya, the vaccine was not readily taken up due to inadequate understanding of the biology and epidemiology of the diseases at the time.’

Scientists in KARI and ILRI continued to refine the technology to the point where it was deemed safe and effective to distribute the vaccine on a commercial basis to farmers. ILRI will continue working with Directors of Veterinary Services in the region to address any research questions that may arise as we continue to use this technology.

It gives me great pleasure today to congratulate the Kenya Department of Veterinary Services on this great occasion of the launch of the East Coast fever vaccine. ILRI is proud to have played a role in this and will continue to offer any research support needed to keep Kenya’s cattle safe from this deadly disease.—Phil Toye

Frontline livestock disease research in, and for, Africa highlighted in White House conversation today

Posted on February 8, 2012 by Susan MacMillan

Scientists at the International Livestock Research Institute (ILRI) are working with many partners to improve control of major diseases of cattle in Africa.

East Coast fever in African cattle, one of the target diseases of the International Livestock Research Institute (ILRI), is included in a message today at the White House delivered by Raj Shah, administrator of the United States Agency for International Development. Shah will remind his audience that East Coast fever kills one cow every 30 seconds in Africa. Watch the live stream and join the conversation at 11am ET at the White House today, when Shah and others will answer questions about Innovations for Global Development.

Two other target diseases of ILRI’s are contagious bovine pleuropneumonia and trypanosomosis. All three diseases affect millions of the world’s poorest farmers. And all remain underfunded because they occur mostly in developing regions of the world.

ILRI recently produced three short films on research battles against these diseases.

CBPP: A new vaccine project starts
Contagious bovine pleuropneumonia (known by its acronym, CBPP) is found throughout most of sub-Saharan Africa, where it causes most harm in pastoralist areas. The disease kills up to 15% of infected animals, reduces the meat and milk yields of infected cows (milk yields drop by up to 90%), and reduces the ability of infected oxen to pull ploughs and do other kinds of farm work. An existing ‘live’ vaccine against this disease produces severe side effects and gives only limited protection.

Watch this short (runtime: 2:35) ILRI film, ‘Developing a Vaccine for a Highly Contagious Cattle Disease’, on the research recently begun at ILRI and its partner institutes, including the Kenya Agricultural Research Institute, to develop a more effective vaccine against this form of acute cattle pneumonia. This research is funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).

Trypanosomosis: A genetic approach to its control
Trypanosomosis, called sleeping sickness in humans, is a wasting disease that maims and eventually kills millions of cattle in Africa and costs farmers billions of dollars annually.

In 2011, using the latest gene mapping and genomic technologies, researchers at ILRI’s Nairobi, Kenya, animal health laboratories and at institutes in the UK and Ireland identified two genes that enable Africa’s ancient N’Dama cattle breed to resist development of the disease when infected with the causative, trypanosome, parasite.

This breakthrough should eventually make it easier for Africa’s livestock breeders to breed animals that will remain healthy and productive in areas infested by the parasite-carrying tsetse fly. The international team that came together in this project is an example of the disciplinary breadth and agility needed to do frontline biology today, and the complex research approaches and technologies now needed to unravel fundamental biological issues so as to benefit world’s poor.

ILRI’s collaborating institutes in this work include Liverpool University; the Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh; Trinity College, Dublin; and the University of Manchester. The Wellcome Trust funded the bulk of the work in this project.

Watch this short (runtime: 5:28) ILRI film, ‘Battling a Killer Cattle Disease’, on the international partnership that made this breakthrough in trypanosomosis research.

Trypanosomosis: A community-based approach to its control
Another ILRI research team has been working with partners and livestock keepers in West Africa to develop safer ways to treat their cattle with drugs to protect them from trypanosomosis. Parasite resistance to the trypanocidal drugs used to treat and prevent this disease has emerged in many areas and is a growing problem for farmers and governments alike. This collaborative research team recently developed good practices in the use of trypanocides to slow the emergence of drug resistance in the parasites that cause the disease. This film describes the disease and these practices, known as ‘rational drug use’, clearly and in detail to help veterinary workers and farmers treat animals safely.

ILRI’s partners in this project include the Centre International de Recherche-Développement sur l’Elevage en Zone Subhumid, Freie Universität Berlin, Laboratoire Vétérinaire Centrale du Mali, Centre Régional de la Recherche Agricole Sikasso, Project de Lutte contra la Mouche Tsétsé et la Trypanosomose (Mali), Pan-African Tsetse and Trypanosomiasis Eradication Campaign (Mali), University of Hannover, Direction Nationale de l’Elevage et l’Institut de Recherche Agronomique de Guinée, Tsetse and Trypanosomosis Control Unit (Ghana), Institut National de la Recherche Agronomique du Bénin and the Nigerian Institute of Trypanosomiasis Research. The project was funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).

Watch this ILRI film, ‘Community-Based Integrated Control of Trypanosomosis in Cattle’ (runtime: 12.48), for clear instructions on how to deploy drugs to better control trypanosomosis over the long term.

Funders meet in Nairobi to align their vision and expectations for pro-poor biosciences research

Posted on December 19, 2011 by Susan MacMillan

Last week (13 Dec 2011), aid agencies that have funded Biosciences eastern and central Africa Hub (BecA Hub), a shared state-of-the-art research and capacity building platform hosted and managed by the International Livestock Research Institute (ILRI) for the region, convened an all-day meeting at ILRI’s Nairobi headquarters. The purpose of the meeting was to harmonize support being provided to BecA and African biosciences and to explore sustainable models for building on the momentum that BecA and its supporters have created.

BecA’s main donors and stakeholders represented at this meeting were the:

Australian Agency for International Development (AusAID)
Bill & Melinda Gates Foundation (BMGF)
Canadian International Development Agency (CIDA, which funded BecA in its beginnings)
New Partnership for Africa’s Development (NEPAD)
Syngenta Foundation for Sustainable Agriculture.

This donor alignment meeting came appropriately on the heels of a recent first meeting of the CEOs of both NEPAD, a program of the Africa Union celebrating its tenth anniversary, and ILRI, one of 16 centres belonging to the Consultative Group on International Agricultural Research (CGIAR), now celebrating 40 years of operation.

NEPAD’s Luke Mumba, who participated in the meeting, brought warm greetings from his CEO, Ibrahim Assane Mayaki, who had paid a recent first visit to ILRI and BecA and reported that NEPAD views BecA ‘as strategically important for affordable and accessible biosciences.’

‘BecA and NEPAD have a common vision to improve livelihoods of the poor,’ Mayaki said. ‘And NEPAD is now interested to play a bigger role in BecA’s programs, helping it to have even greater impact.’

ILRI director general Jimmy Smith thanked Mumba for his message and then framed the ensuing discussion in a talk and slide presentation. The following are excerpts from his talk.

Opening remarks by ILRI’s Jimmy Smith
‘The idea for a Biosciences eastern and Central Africa platform started when I worked for CIDA. It is an initiative I’ve supported since its inception. And I’ve been thinking about BecA since before I rejoined ILRI this November.

‘I liked BecA’s business plan but thought it lacked the “demand side”. I discussed this with Syngenta’s Marco Ferroni, and told him that it’s possible that different donors have different expectations of BecA. I want these to be aligned so that I can fulfill on them.

‘I’d like to frame our discussions today by providing first a bit of context.

Up until 2008 we all believed that food came from supermarkets. Then the world food market went topsy turvy. Prices rose and 100 million people were sent into poverty. Because prices for food were good for some poor farmers, 40 million people also rose out of poverty.

‘Since then, people are once again raising the old Malthusian theory—that massive geometric population growth in the face of arithmetic food growth is bound to lead to great social upheavals.

Here’s what we’re facing. There’ll be 2.5 billion more people by mid-century. We’ll need 70% more food produced to feed the additional population. Specifically, for example, we’ll need 1 billion more tonnes of cereal grains by 2050 for food, feed and biofuels. Most of the additional food will have to come from land already farmed.

‘And we are not starting from zero. There are already 1 billion people in the world who are hungry!

‘75% of people who are poor live in rural areas, but they are at the receiving end of investments of only 4% of official development assistance for agriculture.

‘Donor support to agriculture has fallen from 1980 to 2009. The trendline is inching upwards, but very slowly—and it is not matching the need.

‘In Africa, food production has been increasing but it still lags behind population growth. Africa has been meeting its food needs largely from importation, US$14-billion-worth of cereals each year. This is not sustainable. The continent cannot continue to spend so much on food if it is also going to invest sufficiently in other sectors, such as health and education.

‘The Ford and Rockefeller foundations together financed research that led to the ‘Green Revolution’. This was a group of donors, around a table, with a big vision, which was transformative. My question is, will the creation of BecA be as transformative as that of the Ford and Rockefeller vision was in the sixties? I think it could be.

What are the opportunities for BecA?
‘Every expert who has studied the food situation has said our best possibilities lie in the biotech sciences. People see biotech as a new frontier that has helped us in the past and can continue to do so in the future. We can now do things faster and with more precision. Look how quickly genomes can now be mapped.

This opportunity could be seized and be transformative again. Think if we could produce maize as efficiently as sorghum. What would happen to the maize belt in Africa? Can we create plants whose photosynthesis is more efficient? Can the native African Boran cow produce as much milk as the exotic Jersey?

‘The facility to conduct such science is brought to Africa through the BecA Hub at a scale that could have great impact. It is also here at a size that can greatly help build biosciences capacity on the continent. BecA Hub capacity can leverage the expertise of ILRI and the other centres of the CGIAR. It can catalyze and add value to the agenda of the Comprehensive Africa Agriculture Development Programme.

‘Challenges and questions remain. Can we, for example, develop an explicit agenda setting process that CAADP members will own and invest in? Can we transform our funding base to do transformative science working with CADPP, NARS, universities? Can we put in place an accountability framework that inspires confidence in our donors and partners? Can we bring about more harmonious relationships internally?’

View the slide presentation Jimmy Smith made: The BecA-ILRI Hub: Realizing the promise, 13 Dec 2011.

View a presentation ‘BecA hub research, facilities, and capacity building‘ by Jagger Harvey, Appolinaire Djikeng, and Rob Skilton

Deadly rinderpest virus today declared eradicated from the earth–‘greatest achievement in veterinary medicine’

Posted on June 28, 2011 by Susan MacMillan

At the 79th General Session of the United Nations World Organisation for Animal Health (OIE), in Paris in May 2011, ILRI’s Jeff Mariner (second from right) stands among a group of distinguished people heading work responsible for the eradication of rinderpest, a status officially declared at this meeting (image credit: OIE).

Several world bodies are celebrating what is being described as ‘the greatest achievement in veterinary medicine’: the eradication of only the second disease from the face of the earth.

The disease is rinderpest, which means ‘cattle plague’ in German. It kills animals by a virus—and people by starving them through massive losses of their livestock.

‘In the nineteenth and twentieth centuries,’ reports the United Nations Food and Agriculture Organization (FAO), ‘the disease devastated parts of Africa, triggering extensive famines. . . . After decades of efforts to stamp out a disease that kept crossing national borders, countries and institutions agreed they needed to coordinate their efforts under a single, cohesive programme. In 1994, the Global Rinderpest Eradication Programme (GREP) was established at the UN Food and Agriculture Organization (FAO), in close association with the World Organization for Animal Health (OIE).

‘Excellent science, a massive vaccination effort, close international coordination and the commitment of people at all levels have helped make rinderpest eradication possible.

‘On June 28, 2011, FAO’s governing Conference will adopt a resolution officially declaring that rinderpest has been eradicated from animals worldwide. The successful fight against rinderpest underscores what can be achieved when communities, countries and institutions work together.’

Australian Peter Doherty, 1996 winner of the Nobel Prize for Medicine who served on the board of trustees of the International Laboratory for Research on Animal Diseases (ILRAD), a predecessor of ILRI (photo credit: published on the Advance website).

Australian Peter Doherty, an immunologist who is the only veterinarian to win the Nobel Prize, for Physiology or Medicine, in 1996, and who served as chair of the board of trustees research program of the International Laboratory for Research on Animal Diseases (ILRAD), a predecessor of the International Livestock Research Institute (ILRI), is attending the FAO ceremonies this week. In an interview with FAO, he said:

Vaccine research is currently a very dynamic area of investigation and with sufficient investment and the enthusiastic participation of industry partners at the “downstream” end, we can achieve even better vaccines against many veterinary and human diseases.

The Washington Post in May reported that ‘the World Organization for Animal Health, at its annual meeting in Paris on Wednesday, accepted documentation from the last 14 countries that they were now free of rinderpest. The organization, which goes by its French acronym, OIE, was started in 1924 in response to a rinderpest importation in Europe.

‘The most recent recorded outbreak occurred in Kenya in 2001. Much of the past decade has been spent looking for new cases, in domesticated animals and in the wild, wandering herds of ungulates, or hoofed animals, in East Africa. The last place of especially intense surveillance was Somalia, where the final outbreak of smallpox occurred in 1977.

‘“There are a huge number of unsung heroes in lots of countries that made this possible,” said Michael Baron, a rinderpest virologist at the Institute for Animal Health in Surrey, England. “In most places, they were ordinary veterinary workers who were doing the vaccination, the surveillance, the teaching.”

‘Three things made rinderpest eradicable. Animals that survived infection became immune for life. A vaccine developed in the 1960s by Walter Plowright, an English scientist who died last year at 86, provided equally good immunity. And even though the virus could infect wild animals, it did not have a reservoir of host animals capable of carrying it for prolonged periods without becoming ill.

‘In 1994, the FAO launched an eradication program that was largely financed by European countries, although the United States, which never had rinderpest, also contributed money. The effort consisted of massive vaccination campaigns, which were made more practicable when two American researchers made a version of the Plowright vaccine that required no refrigeration. . . .’

One of those researchers was Jeffrey Mariner, now working at ILRI, in Nairobi, Kenya. Mariner also helped in surveillance work ‘with a technique called “participatory epidemiology” in which outside surveyors meet with herdsmen and ask open-ended questions about the health of their animals and when they last noticed certain symptoms.

‘“It was local knowledge that really helped us trace back the last places where transmission occurred—sitting down underneath a tree in the shade, listening to storytelling,” said Lubroth, of the FAO. . . .’

Read the whole article in the Washington Post, Rinderpest, or ‘cattle plague,’ becomes only second disease to be eradicated, 27 May 2011.

Read FAO’s interview of Peter Doherty: Healthier animals, healthier people, June 2011.

Scientists identify livestock genes to unlock protection against one of Africa’s oldest animal plagues

Posted on May 18, 2011 by Susan MacMillan

Cow suffering from trypanosomiasis (photo credit: ILRI/Elsworth).

An international research team using a new combination of approaches has found two genes that may prove of vital importance to the lives and livelihoods of millions of farmers in a tsetse fly-plagued swathe of Africa the size of the United States. The team’s results were published today in the Proceedings of the National Academy of Sciences (PNAS).

The research, aimed at finding the biological keys to protection from a single-celled trypanosome parasite that causes both African sleeping sickness in people and a wasting disease in cattle, brought together a range of high-tech tools and field observations to address a critical affliction of some of the world’s poorest people.

With increased surveillance and control, sleeping sickness infections in people have dropped ten-fold in the last 13 years, from an estimated 300,000 cases a year in 1998 to some 30,000 in 2009, with the disease eventually killing more than half of those infected. Although best known for causing human sleeping sickness, the trypanosome parasite’s most devastating blow to human welfare comes in an animal form, with sick, unproductive cattle costing mixed crop-livestock farmers and livestock herders huge losses and opportunities. The annual economic impact of ‘nagana,’ a common name in Africa for the form of the disease that affects cattle (officially known as African animal trypanosomiasis), has been estimated at US$4–5 billion.

In a vast tsetse belt across Africa, stretching from Senegal on the west coast to Tanzania on the east coast, and from Chad in the north to Zimbabwe in the south, the disease each year renders millions of cattle too weak to plow land or to haul loads, and too sickly to give milk or to breed, before finally killing off most of those infected. This means that in much of Africa, where tractors and commercial fertilizers are scarce and prohibitively expensive, cattle are largely unavailable for tilling and fertilizing croplands or for producing milk and meat for families. The tsetse fly and the disease it transmits are thus responsible for millions of farmers having to till their croplands by hand rather than by animal-drawn plow.

‘The two genes discovered in this research could provide a way for cattle breeders to identify the animals that are best at resisting disease when infected with trypanosome parasites, which are transmitted to animals and people by the bite of infected tsetse flies,’ said senior author Steve Kemp, a geneticist on joint appointment with the Nairobi-based International Livestock Research Institute (ILRI) and the University of Liverpool.

This genetics of disease resistance research was led by scientists from ILRI in Africa and from the UK universities of Liverpool, Manchester and Edinburgh, and involved researchers from other institutions in Britain, Ireland and South Korea.

The researchers drew on the fact that while the humped cattle breeds characteristic of much of Africa are susceptible to disease-causing trypanosome parasites, a humpless West African breed, called the N’Dama, is not seriously affected by the disease. Having been domesticated in Africa some 8,000 or more years ago, this most ancient of African breeds has had time to evolve resistance to the parasites. This makes the N’Dama a valued animal in Africa’s endemic regions. On the other hand, N’Dama cattle tend to be smaller, to produce less milk, and to be less docile than their bigger, humped cousins.

African agriculturalists of all kinds would like to see the N’Dama’s inherent disease resistance transferred to these other more productive breeds, but this is difficult without precise knowledge of the genes responsible for disease resistance in the N’Dama. Finding these genes has been the ‘Holy Grail’ of a group of international livestock geneticists for more than two decades, but the genetic and other biological pathways that control bovine disease resistance are complex and have proven difficult to determine.

The PNAS paper is thus a landmark piece of research in this field. The international and inter-institutional team that made this breakthrough did so by combining a range of genetic approaches, which until now have largely been used separately.

‘This may be the first example of scientists bringing together different ways of getting to the bottom of the genetics of a very complex trait,’ said Kemp. ‘Combined, the data were like a Venn diagram overlaying different sets of evidence. It was the overlap that interested us.’

They used these genetic approaches to distinguish differences between the ‘trypano-tolerant’ (humpless) N’Dama, which come from West Africa, and ‘trypano-susceptible’ (humped) Boran cattle, which come from Kenya, in East Africa. The scientists first identified the broad regions of their genomes controlling their different responses to infection with trypanosome parasites, but this was insufficient to identify the specific genes controlling resistance to the disease. So the scientists began adding layers of information obtained from other approaches. They sequenced genes from these regions to look for differences in those sequences between the two breeds.

The team at Edinburgh conducted gene expression analyses to investigate any differences in genetic activity in the tissues of the two cattle breeds after sets of animals of both breeds were experimentally infected with the parasites. Then, the ILRI group tested selected genes in the lab. Finally, they looked at the genetics of cattle populations from all over Africa.

Analyzing the vast datasets created in this research presented significant computational challenges. Andy Brass and his team in the School of Computer Science at the University of Manchester managed to capture, integrate and analyze the highly complex set of biological data by using workflow software called ‘Taverna,’ which was developed as part of a UK e-Science initiative by Manchester computer scientist Carole Goble and her ‘myGrid’ team.

‘The Taverna workflows we developed are capable of analyzing huge amounts of biological data quickly and accurately,’ said Brass. ‘Taverna’s infrastructure enabled us to develop the systematic analysis pipelines we required and to rapidly evolve the analysis as new data came into the project. We’re sharing these workflows so they can be re-used by other researchers looking at different disease models. This breakthrough demonstrates the real-life benefits of computer science and how a problem costing many lives can be tackled using pioneering E-Science systems.’

To bolster the findings, population geneticists from ILRI and the University of Dublin examined bovine genetic sequences for clues about the history of the different breeds. Their evidence confirmed that the two genes identified by the ILRI-Liverpool-Manchester groups were likely to have evolved in response to the presence of trypanosome parasites.

‘We believe the reason the N’Dama do not fall sick when infected with trypanosome parasites is that these animals, unlike others, have evolved ways to control the infection without mounting a runaway immune response that ends up damaging them,’ said lead author Harry Noyes, of the University of Liverpool. ‘Many human infections trigger similarly self-destructive immune responses, and our observations may point to ways of reducing such damage in people as well as livestock.’

This paper, said Kemp, in addition to advancing our understanding of the cascade of genes that allow Africa’s N’Dama cattle to fight animal trypanosomiasis, reaffirms the importance of maintaining as many of Africa’s indigenous animal breeds (as well as plant/crop varieties) as possible. The N’Dama’s disease resistance to trypanosome parasites is an example of a genetic trait that, while not yet fully understood, is clearly of vital importance to the continent’s future food security. But the continued existence of the N’Dama, like that of other native ‘niche’ African livestock breeds, remains under threat.

With this new knowledge of the genes controlling resistance to trypanosomiasis in the N’Dama, breeders could screen African cattle to identify animals with relatively high levels of disease resistance and furthermore incorporate the genetic markers for disease resistance with markers for other important traits, such as high productivity and drought tolerance, for improved breeding programs generally.

If further research confirms the significance of these genes in disease resistance, a conventional breeding program could develop a small breeding herd of disease-resistant cattle in 10–15 years, which could then be used over the next several decades to populate Africa’s different regions with animals most suited to those regions. Using genetic engineering techniques to achieve the same disease-resistant breeding herd, an approach still in its early days, could perhaps be done in four or five years, Kemp said. Once again, it would be several decades before such disease-resistant animals could be made available to most smallholder farmers and herders on the continent.

‘So it’s time we got started,’ said Kemp.

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See this news and related background material at ILRI’s online press room.

The International Livestock Research Institute (www.ilri.org) works with partners worldwide to help poor people keep their farm animals alive and productive, increase and sustain their livestock and farm productivity, and find profitable markets for their animal products. ILRI’s headquarters are in Nairobi, Kenya; we have a principal campus in Addis Ababa, Ethiopia, and 13 offices in other regions of Africa and Asia. ILRI is part of the Consultative Group on International Agricultural Research (www.cgiar.org), which works to reduce hunger, poverty, illness and environmental degradation in developing countries by generating and sharing relevant agricultural knowledge, technologies and policies. This research is focused on development, conducted by a Consortium (http://consortium.cgiar.org) of 15 CGIAR centres working with hundreds of partners worldwide, and supported by a multi-donor Fund (www.cgiarfund.org).

The University of Liverpool (www.liv.ac.uk) is a member of the Russell Group of leading research-intensive institutions in the UK. It attracts collaborative and contract research commissions from a wide range of national and international organizations valued at more than £110 million annually.

The University of Manchester (www.manchester.ac.uk), also a member of the Russell Group, is the largest single-site university in the UK. It has 22 academic schools and hundreds of specialist research groups undertaking pioneering multi-disciplinary teaching and research of worldwide significance. According to the results of the 2008 Research Assessment Exercise, the University of Manchester is now one of the country’s major research universities, rated third in the UK in terms of ‘research power’. The university has an annual income of £684 million and attracted £253 million in external research funding in 2007/08.

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