Scientists at the International Livestock Research Institute (ILRI) are working with many partners to improve control of major diseases of cattle in Africa.
East Coast fever in African cattle, one of the target diseases of the International Livestock Research Institute (ILRI), is included in a message today at the White House delivered by Raj Shah, administrator of the United States Agency for International Development. Shah will remind his audience that East Coast fever kills one cow every 30 seconds in Africa. Watch the live stream and join the conversation at 11am ET at the White House today, when Shah and others will answer questions about Innovations for Global Development.
Two other target diseases of ILRI’s are contagious bovine pleuropneumonia and trypanosomosis. All three diseases affect millions of the world’s poorest farmers. And all remain underfunded because they occur mostly in developing regions of the world.
ILRI recently produced three short films on research battles against these diseases.
CBPP: A new vaccine project starts
Contagious bovine pleuropneumonia (known by its acronym, CBPP) is found throughout most of sub-Saharan Africa, where it causes most harm in pastoralist areas. The disease kills up to 15% of infected animals, reduces the meat and milk yields of infected cows (milk yields drop by up to 90%), and reduces the ability of infected oxen to pull ploughs and do other kinds of farm work. An existing ‘live’ vaccine against this disease produces severe side effects and gives only limited protection.
Watch this short (runtime: 2:35) ILRI film, ‘Developing a Vaccine for a Highly Contagious Cattle Disease’, on the research recently begun at ILRI and its partner institutes, including the Kenya Agricultural Research Institute, to develop a more effective vaccine against this form of acute cattle pneumonia. This research is funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).
Trypanosomosis: A genetic approach to its control
Trypanosomosis, called sleeping sickness in humans, is a wasting disease that maims and eventually kills millions of cattle in Africa and costs farmers billions of dollars annually.
In 2011, using the latest gene mapping and genomic technologies, researchers at ILRI’s Nairobi, Kenya, animal health laboratories and at institutes in the UK and Ireland identified two genes that enable Africa’s ancient N’Dama cattle breed to resist development of the disease when infected with the causative, trypanosome, parasite.
This breakthrough should eventually make it easier for Africa’s livestock breeders to breed animals that will remain healthy and productive in areas infested by the parasite-carrying tsetse fly. The international team that came together in this project is an example of the disciplinary breadth and agility needed to do frontline biology today, and the complex research approaches and technologies now needed to unravel fundamental biological issues so as to benefit world’s poor.
ILRI’s collaborating institutes in this work include Liverpool University; the Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh; Trinity College, Dublin; and the University of Manchester. The Wellcome Trust funded the bulk of the work in this project.
Watch this short (runtime: 5:28) ILRI film, ‘Battling a Killer Cattle Disease’, on the international partnership that made this breakthrough in trypanosomosis research.
Trypanosomosis: A community-based approach to its control
Another ILRI research team has been working with partners and livestock keepers in West Africa to develop safer ways to treat their cattle with drugs to protect them from trypanosomosis. Parasite resistance to the trypanocidal drugs used to treat and prevent this disease has emerged in many areas and is a growing problem for farmers and governments alike. This collaborative research team recently developed good practices in the use of trypanocides to slow the emergence of drug resistance in the parasites that cause the disease. This film describes the disease and these practices, known as ‘rational drug use’, clearly and in detail to help veterinary workers and farmers treat animals safely.
ILRI’s partners in this project include the Centre International de Recherche-Développement sur l’Elevage en Zone Subhumid, Freie Universität Berlin, Laboratoire Vétérinaire Centrale du Mali, Centre Régional de la Recherche Agricole Sikasso, Project de Lutte contra la Mouche Tsétsé et la Trypanosomose (Mali), Pan-African Tsetse and Trypanosomiasis Eradication Campaign (Mali), University of Hannover, Direction Nationale de l’Elevage et l’Institut de Recherche Agronomique de Guinée, Tsetse and Trypanosomosis Control Unit (Ghana), Institut National de la Recherche Agronomique du Bénin and the Nigerian Institute of Trypanosomiasis Research. The project was funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).
Watch this ILRI film, ‘Community-Based Integrated Control of Trypanosomosis in Cattle’ (runtime: 12.48), for clear instructions on how to deploy drugs to better control trypanosomosis over the long term.
From the White House Blog comes this report of the event:
‘Today at the White House, senior Administration officials announced a series of new initiatives to promote game-changing innovations to solve long-standing development challenges. Answering President Obama’s call to harness science technology, and innovation to spark global development, the Administration announced initiatives from across the government to generate new development solutions. Announcements include new partnerships with universities; greater use of scientific breakthroughs through expedited technology transfer of federally-funded inventions; a program to reward inventors who use their patented technologies to address humanitarian needs; and initiatives to leverage advances in Internet and communications technologies to provide new development tools.
‘In an increasingly globalized world, the Obama Administration recognizes that global development is vital to national security and is a strategic, economic, and moral imperative. One of the cornerstones of our global development policy is a commitment to investments in game-changing innovations with the potential to solve long-standing development challenges in health, food security, environmental sustainability, and broad-based economic growth. Innovation can play a key role in building a stable, inclusive global economy with new sources of prosperity, advancing democracy and human rights, and helping us to increase the ranks of prosperous, capable, and democratic states that can be our partners in the decades to come.
‘Administrator Raj Shah announced that USAID is launching a new partnership with universities and research institutes to define and solve large development challenges. USAID also announced new commitments to increased utilization of electronic and mobile payments to save on costs and increase financial access; a new effort to make assistance to other governments in telecommunications development more efficient; a new “app store” for development to spur humanitarian apps and software; and new commitments to mobile education technology as part of USAID’s All Children Reading grand challenge for development.
‘. . . The National Institutes of Health launched a new model licensing agreement to expedite licenses to not-for-profit institutions with a demonstrated commitment to diligence in providing broad global access to technologies. . . .
‘Additionally, NIH announced that it is joining with private sector partners to develop Global Health Connect, a free online database of disease data and information that will bring disparate databases and research together to accelerate the development of lifesaving treatments and combat the neglected tropical diseases that afflict the world’s poorest people. . . .’