Tag Archives: Trypanosomosis

Frontline livestock disease research in, and for, Africa highlighted in White House conversation today

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Scientists at the International Livestock Research Institute (ILRI) are working with many partners to improve control of major diseases of cattle in Africa.

East Coast fever in African cattle, one of the target diseases of the International Livestock Research Institute (ILRI), is included in a message today at the White House delivered by Raj Shah, administrator of the United States Agency for International Development. Shah will remind his audience that East Coast fever kills one cow every 30 seconds in Africa. Watch the live stream and join the conversation at 11am ET at the White House today, when Shah and others will answer questions about Innovations for Global Development.

Two other target diseases of ILRI’s are contagious bovine pleuropneumonia and trypanosomosis. All three diseases affect millions of the world’s poorest farmers. And all remain underfunded because they occur mostly in developing regions of the world.

ILRI recently produced three short films on research battles against these diseases.

CBPP: A new vaccine project starts
Contagious bovine pleuropneumonia (known by its acronym, CBPP) is found throughout most of sub-Saharan Africa, where it causes most harm in pastoralist areas. The disease kills up to 15% of infected animals, reduces the meat and milk yields of infected cows (milk yields drop by up to 90%), and reduces the ability of infected oxen to pull ploughs and do other kinds of farm work. An existing ‘live’ vaccine against this disease produces severe side effects and gives only limited protection.

Watch this short (runtime: 2:35) ILRI film, ‘Developing a Vaccine for a Highly Contagious Cattle Disease’, on the research recently begun at ILRI and its partner institutes, including the Kenya Agricultural Research Institute, to develop a more effective vaccine against this form of acute cattle pneumonia. This research is funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).

Trypanosomosis: A genetic approach to its control
Trypanosomosis, called sleeping sickness in humans, is a wasting disease that maims and eventually kills millions of cattle in Africa and costs farmers billions of dollars annually.

In 2011, using the latest gene mapping and genomic technologies, researchers at ILRI’s Nairobi, Kenya, animal health laboratories and at institutes in the UK and Ireland identified two genes that enable Africa’s ancient N’Dama cattle breed to resist development of the disease when infected with the causative, trypanosome, parasite.

This breakthrough should eventually make it easier for Africa’s livestock breeders to breed animals that will remain healthy and productive in areas infested by the parasite-carrying tsetse fly. The international team that came together in this project is an example of the disciplinary breadth and agility needed to do frontline biology today, and the complex research approaches and technologies now needed to unravel fundamental biological issues so as to benefit world’s poor.

ILRI’s collaborating institutes in this work include Liverpool University; the Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh; Trinity College, Dublin; and the University of Manchester. The Wellcome Trust funded the bulk of the work in this project.

Watch this short (runtime: 5:28) ILRI film, ‘Battling a Killer Cattle Disease’, on the international partnership that made this breakthrough in trypanosomosis research.

 

Trypanosomosis: A community-based approach to its control
Another ILRI research team has been working with partners and livestock keepers in West Africa to develop safer ways to treat their cattle with drugs to protect them from trypanosomosis. Parasite resistance to the trypanocidal drugs used to treat and prevent this disease has emerged in many areas and is a growing problem for farmers and governments alike. This collaborative research team recently developed good practices in the use of trypanocides to slow the emergence of drug resistance in the parasites that cause the disease. This film describes the disease and these practices, known as ‘rational drug use’, clearly and in detail to help veterinary workers and farmers treat animals safely.

ILRI’s partners in this project include the Centre International de Recherche-Développement sur l’Elevage en Zone Subhumid, Freie Universität Berlin, Laboratoire Vétérinaire Centrale du Mali, Centre Régional de la Recherche Agricole Sikasso, Project de Lutte contra la Mouche Tsétsé et la Trypanosomose (Mali), Pan-African Tsetse and Trypanosomiasis Eradication Campaign (Mali), University of Hannover, Direction Nationale de l’Elevage et l’Institut de Recherche Agronomique de Guinée, Tsetse and Trypanosomosis Control Unit (Ghana), Institut National de la Recherche Agronomique du Bénin and the Nigerian Institute of Trypanosomiasis Research. The project was funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).

Watch this ILRI film, ‘Community-Based Integrated Control of Trypanosomosis in Cattle’ (runtime: 12.48), for clear instructions on how to deploy drugs to better control trypanosomosis over the long term.

Short film illustrates expanded, agile partnerships behind recent disease research breakthrough

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This short (5-minute) film, ‘Battling a Killer Cattle Disease’, produced by the International Livestock Research Institute (ILRI), provides background and context for a recent research breakthrough made at ILRI’s animal health laboratories in Nairobi, Kenya, and at their partner institutions in the UK and Ireland. The research was funded over 7 years in large part by the Wellcome Trust in addition to the Consultative Group on International Agricultural Research (CGIAR).

Trypanosomosis is a wasting disease of livestock that maims and eventually kills millions of cattle in Africa and costs the continent billions of dollars annually.

In 2011, a group of geneticists at these collaborating institutions identified two genes that enable Africa’s ancient N’Dama cattle breed to resist development of the disease trypanosomosis when infected with the causative, trypanosome, parasite.

The team members were able to make use of the latest gene mapping and genomic technologies because they had the genetic systems and experimental populations of livestock in place to do so as these technologies came on stream.

Eventually, these results should make it easier for livestock breeders in Africa to breed animals that will remain healthy and productive in areas infested by the disease-carrying tsetse fly.

The international team that came together in this project is an example of the disciplinary breadth as well as agility needed to do frontline biology today. In this work, the team developed several new research approaches and technologies that were needed to unravel some fundamental biological issues, with likely benefits for many African farmers and herders.

Those interviewed in the film include Harry Noyes, at the University of Liverpool; Alan Archibald, at the Roslin Institute at the University of Edinburgh; Andy Brass, at the University of Manchester; and Steve Kemp and Morris Agaba, at ILRI.

Rational drug use by vets and farmers can control trypanosomosis, ‘the malaria of cattle’ in Africa

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Livestock keepers in West Africa rely largely on treating their cattle with drugs to protect them from trypanosomosis, a wasting disease transmitted by the tsetse fly. But parasite resistance to these drugs has emerged in many areas.

This 13-minute film by the International Livestock Research Institute (ILRI) outlines good practices for improving the use of drugs and slowing the emergence of resistance. These practices, which are based on rational drug use, an approach from human health now adapted for animal care, are clearly explained so that veterinary workers and farmers can treat animals safely. Rational drug use can be combined with other methods that reduce the numbers of tsetse flies to further slow the spread of resistance to trypanocidal medicines.

This is one of three ILRI films telling the story of the current state of the war against a disease that is so deadly and widespread that farmers call it ‘the malaria of cattle’.

Kenya study finds prototype tsetse-repellent technology does not sufficiently protect cattle under normal field conditions

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Testing a tsetse-repellent technology

Cattle fitted with tsetse-repellent dispensers suspended from neck collars were used to test the effectiveness of a prototype tsetse repellent in preventing tsetse fly bites (Photo credit: ILRI/Bett).

Recently published findings from a study done among Maasai livestock in Kenya to test whether repellents can successfully reduce tsetse fly bites in cattle show that tsetse-repellent technologies may have some success in typical field conditions but do not yet offer a viable alternative for controlling trypanosomosis in field-based livestock.

The study, ‘Field trial of a synthetic tsetse-repellent technology developed for the control of bovine trypanosomosis in Kenya,’ was the first to evaluate the use of a mobile tsetse repellent in the field. It was conducted between April 2005 and August 2006 in Nkuruman, in Kajiado District, and Nkineji, in Narok District.

Trypanosomosis is the most pervasive and serious cattle disease in sub-Saharan Africa. It kills between three and seven million cattle each year and costs farmers millions of dollars in lost production and treatment costs. The disease is transmitted mainly by blood-feeding tsetse flies that infect susceptible animals with the causative trypanosome parasite during their feeding. Other trypanosome parasites can infect humans, causing sleeping sickness, a disease that attacks the central nervous system.

Animal trypanosomosis is difficult to control because its spread is influenced by many factors, including the age, sex and colour of the cattle at risk as well as the herd size, its geographical area and climate. Adult and male cattle, for example, are more likely to contract the disease than calves and females. And tsetse flies prefer to take their feeds from animals with dark coats.

International Livestock Research Institute (ILRI) researchers Bernard Bett, Tom Randolph and John McDermott participated in the evaluation, which was designed with the help of veteran African tsetse researchers Glyn Vale and John Hargrove, and Steve Torr of Greenwich University (UK). The evaluation involved 2000 cattle: 1000 formed the control group, while the other 1000 animals were fitted with tsetse-repellent dispensers suspended from neck collars. The effectiveness of the repellent was then monitored for 16 months.

The study stipulated at the outset that the repellent would be considered effective if it reduced the incidence of trypanosomosis by 50 percent or more in the repellent-treated animals versus the control animals. Failure to achieve this level of reduction would mean that the repellent technology was clearly not ‘a viable alternative to existing control techniques’.

Results from the trial showed that the technology reduces trypanosomosis infection rates only modestly. ‘The synthetic repellent reduced the incidence of the disease only by 18 percent,’ said Bett, the ILRI scientist who implemented the trial.

Bett went on to explain that the technology had been proposed for evaluation based on initial experiments using stationary cattle that suggested that the repellents could reduce infection rates by more than 80 percent. ‘Under typical field conditions, however,’ said Bett, ‘the repellent did not provide adequate levels of protection, so we are recommending that it not be considered for further commercial development at this point.’

That the effectiveness of the repellent in the field was lower than expected could be attributed to both the fragile nature of the repellent dispensers, which, sensitive to abrasions, often leaked, as well as the repellent itself. Tsetse flies, especially hungry ones, will alight even on animals that smell bad to them. This is why people, for example, whose odour should put off tsetse flies, still get bitten by them.

‘The earlier experiments might have also overestimated the benefit of the technology,’ said Bett. ‘Those initial experiments evaluated the reduction in numbers of flies feeding on tethered cattle; other flies, however, could bite quickly without feeding and still transmit the disease before the repellent drives them away. In addition, while flies mainly use odour to find a stationary cow, they use vision more than odour to guide them to moving animals, such as those in the pastoralist herds used in the field trial.’

The study found that many variables determine the effectiveness of the repellent technology. Among these are changes in grazing (during the dry season, herders tend to move their stock to pastures with higher densities of tsetse) and herd sizes (the larger the herd, the lesser are the chances that an individual animal within the herd will be bitten). Trypanosomosis incidence also differed in the two test districts. While cattle were the preferred hosts for the flies in Narok, the cattle in Kajiado came fifth in fly preference—after warthog, elephant, zebra and buffalo—which reduced the effectiveness of the repellent worn by the cattle.

Bett says that ‘the results of this study show that the tsetse-repellent technologies currently proposed are unlikely to be useful replacements of existing methods of controlling trypanosomosis.’ These include keeping indigenous ‘trypanotolerant’ cattle breeds, which can tolerate trypanosome infections without getting sick; treating sick animals with trypanocidal drugs to cure them of the disease; introducing sterile tsetse flies into an area to reduce its tsetse population; and controlling tsetse populations using pyrethrum-based insecticides.’

The findings of this study should help scientists improve their research on methods for controlling tsetse fly populations and the trypanosomosis they spread. ‘In the short term, however,’ says Bett, ‘we need to continue sensitizing livestock keepers on how to best use the existing control methods.’

‘We also urgently need to develop integrated strategies for controlling the fly and disease,’ concludes Bett, ‘so that we stop over-relying on popular interventions, such as regularly treating cattle with trypanocides, which will inevitably lead to drug resistance in the trypanosome parasites.’

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Read the complete findings of the evaluation on this link http://dx.doi.org/10.1016/j.prevetmed.2010.09.001

This blog entry by Tezira Lore, a communication specialist with ILRI’s Market Opportunities Theme, compares findings of this field trial with findings of other ILRI studies in typanosomosis.

Experts warn rapid losses of Africa’s native livestock threaten continent’s food supply

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N'DamaHerd_WestAfrica

Resilient disease-resistant, 'ancient' West African cattle, such as these humpless longhorn N'Dama cattle, are among breeds at risk of extinction in Africa as imported animals supplant valuable native livestock

Urgent action is needed to stop the rapid and alarming loss of genetic diversity of African livestock that provide food and income to 70 percent of rural Africans and include a treasure-trove of drought- and disease-resistant animals, according to a new analysis presented today at a major gathering of African scientists and development experts.

Experts from the International Livestock Research Institute (ILRI) told researchers at the 5th African Agriculture Science Week (www.faraweek.org), hosted by the Forum for Agricultural Research in Africa (FARA), that investments are needed now to expand efforts to identify and preserve the unique traits, particularly in West Africa, of the continent's rich array of cattle, sheep, goats and pigs developed over several millennia but now under siege. They said the loss of livestock diversity in Africa is part of a global 'livestock meltdown'. According to the United Nations Food and Agriculture Organization, some 20 percent of the world's 7616 livestock breeds are now viewed as at risk.

'Africa's livestock are among the most resilient in the world yet we are seeing the genetic diversity of many breeds being either diluted or lost entirely', said Abdou Fall, leader of ILRI's livestock diversity project for West Africa. 'But today we have the tools available to identify valuable traits in indigenous African livestock, information that can be crucial to maintaining and increasing productivity on African farms.'

Fall described a variety of pressures threatening the long-term viability of livestock production in Africa. These forces include landscape degradation and cross-breeding with 'exotic' breeds imported from Europe, Asia and the America.

For example, disease-susceptible breeds from West Africa's Sahel zone are being cross-bred in large scale with breeds adapted to sub-humid regions, like southern Mali, that have a natural resistance to trypanosomosis.

Trypanosomosis kills an estimated three to seven million cattle each year and costs farmers billions of dollars each year in, for example, lost milk and meat production and the costs of medicines and prophylactics needed to treat or prevent the disease. While cross-breeding may offer short-term benefits, such as improved meat and milk production and greater draft power, it could also cause the disappearance of valuable traits developed over thousands of years of natural selection.

ILRI specialists are in the midst of a major campaign to control development of drug resistance in the parasites that cause this disease but also have recognized that breeds endowed with a natural ability to survive the illness could offer a better long-term solution.

The breeds include humpless shorthorn and longhorn cattle of West and Central Africa that have evolved in this region along with its parasites for thousands of years and therefore have evolved ways to survive many diseases, including trypanosomosis, which is spread by tsetse flies, and also tick-borne diseases. Moreover, these hardy animals have the ability to withstand harsh climates. Despite their drawbacks—the shorthorn and longhorn breeds are not as productive as their European counterparts—their loss would be a major blow to the future of African livestock productivity.

'We have seen in the short-horn humpless breeds native to West and Central African indiscriminate slaughter and an inattention to careful breeding that has put them on a path to extinction', Fall said . 'We must at the very least preserve these breeds either on the farm or in livestock genebanks because their genetic traits could be decisive in the fight against trypanosomosis, while their hardiness could be enormously valuable to farmers trying to adapt to climate change.'

Other African cattle breeds at risk include the Kuri cattle of southern Chad and northeastern Nigeria. The large bulbous-horned Kuri, in addition to being unfazed by insect bites, are excellent swimmers, having evolved in the Lake Chad region, and are ideally suited to wet conditions in very hot climates.

ILRI's push to preserve Africa's indigenous livestock is part of a broader effort to improve productivity on African farms through what is known as 'landscape genomics'. Landscape genomics involves, among other things, sequencing the genomes of different livestock varieties from many regions and looking for the genetic signatures associated with their suitability to a particular environment.

ILRI experts see landscape genomics as particularly important as climate change accelerates, requiring animal breeders to respond every more quickly and expertly to shifting conditions on the ground. But they caution that in Africa in particular the ability of farmers and herders to adapt to new climates depends directly on the continent's wealth of native livestock diversity.

'What we see too often is an effort to improve livestock productivity on African farms by supplanting indigenous breeds with imported animals that over the long-term will prove a poor match for local conditions and require a level of attention that is simply too costly for most smallholder farmers', said Carlos Seré, ILRI's Director General. 'What marginalized livestock-keeping communities need are investments in genetics and genomics that allow them to boost productivity with their African animals, which are best suited to their environments.'

Seré said new polices also are needed that encourage African pastoralist herders and smallholder farmers to continue maintaining their local breeds rather than abandoning them for imported animals. Such policies, he said, should include breeding programs that focus on improving the productivity of indigenous livestock as an alternative to importing animals.

Steve Kemp, who heads ILRI's genetics and genomics team, added that in addition to conservation on the farm, there must also be investments in preserving diversity by freezing sperm and embryos because farmers cannot be asked to forgo productivity increases solely in the name of diversity conservation.

'We cannot expect farmers to sacrifice their income just to preserve the future potential of diversity', Kemp said. 'We know that diversity is critical to dealing with the challenges that confront African farmers, but the valuable traits that may be important in the future are not always immediately obvious.'

Kemp called for a new approach to measuring the characteristics of livestock genetic resources. Today, he said, these estimates focus mainly on such things as the value of meat, milk, eggs and wool and do not include qualities that can be of equal or even greater importance to livestock keepers in Africa and other developing regions. These attributes include the ability of an animal to pull a plough, provide fertilizer, serve as a walking bank or savings account, and act as an effective form of insurance against crop loss.

But associating this wider array of attributes with an animal's DNA requires new ways of exploring and understanding livestock characteristics in a region where there is so much diversity in so many different environments.

'The tools are available to do this now, but we need the will, the imagination and the resources before it is too late', Kemp said.

US$4.4 million awarded for research to build a climate model able to predict outbreaks of infectious disease in Africa

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Cow suffering from trypanosomosis

Scientists at the University of Liverpool, in the UK, and the International Livestock Research Institute (ILRI), in Kenya, are working with 11 other African and European partners on a US$4.4-million (UK£3 million-) project to develop climate-based models that will help predict the outbreak and spread of infectious diseases in Africa.

The researchers are working to integrate data from climate modelling and disease-forecasting systems so that the model can predict, six months in advance, the likelihood of an epidemic striking. The research, funded by the European Commission Seventh Framework, is being conducted in Ghana, Malawi and Senegal. It aims to give decision-makers the time needed to deploy intervention methods to stop large-scale spread of diseases such as Rift Valley fever and malaria, both of which are transmitted by mosquitoes.

It is thought that climate change will change global disease distributions, and although scientists know a lot about the climate triggers for some diseases, they don’t know much about how far into the future these disease events can be predicted. This new project brings together experts to investigate the links between climate and vector-borne diseases, including ‘zoonotic’ diseases, which are transmissible between animals and humans.

ILRI veterinary researcher Delia Grace says that diseases shared by people and animals are under-investigated although they are critically important for public health. ‘Fully 60% of all human diseases, and 75% of emerging diseases such as bird flu, are transmitted between animals and people,’ she said.

ILRI geneticist Steve Kemp said that the project is making use of ILRI’s advanced genomics capacities to analyse pathogens from the field and to integrate the data collected on both pathogen distribution and climatic factors. ‘From ILRI’s point of view,’ Kemp said, ‘this project is particularly exciting because it brings strong climate and weather expertise that complements systems recently built by ILRI and its partners to detect outbreaks of Rift Valley fever and to determine its spread.’

The new project also complements ILRI’s ongoing work to better control trypansomosis in West African livestock, a disease transmitted by tsetse flies. Trypanosomosis, which is related to sleeping sickness in humans, causes devastating losses of animals—along with animal milk, meat, manure, traction and other benefits—across a swath Africa as big as continental USA. Members of the new modeling project will conduct research in some of the same locations as ILRI’s West African trypanosomosis project, Kemp explained, and work with some of the same partner organizations, which should generate synergies that benefit both projects.

The risk of epidemics in tropical countries increases shortly after a season of good rainfall—when heat and humidity allow insects, such as mosquitoes, to thrive and spread diseases. Matthew Baylis, from Liverpool’s School of Veterinary Science, explained how this works with Rift Valley fever: ‘Rift Valley fever can spread amongst the human and animal population during periods of heavy rain, when floodwater mosquitoes flourish and lay their eggs. If this rainfall occurs unexpectedly during the dry season, when cattle are kept in the villages rather than out on the land, the mosquitoes can infect the animals at the drinking ponds. Humans can then contract the disease by eating infected animals. Working with partners in Africa, we can bring this information together to build a much more accurate picture of when to expect epidemics.

Andy Morse, from Liverpool’s School of Environmental Sciences, said the project combines historical and contemporary climate data with disease incidence information, including that for vector-borne diseases, as well as integrating monthly and seasonal forecasts. The resulting single, seamless, forecast system, Morse said, should allow projections of disease risk to be made beyond the conventional predictable time limit. ‘All this information will be fed into a decision-support system to be developed with decision-makers on national health issues’ in the three target countries.

The project was launched at a conference at the University of Liverpool on 19 April 2010.

For more information, contact ILRI scientist Steve Kemp. ILRI email contacts are formatted as follows: f.surname@cgiar.org: replace ‘f’ with the staff member’s first initial and replace ‘surname’ with the staff member’s surname.

The 13 research partners:
Abdus Salam International Centre for Theoretical Physics (Italy), Centre de Suivi Ecologique (Senegal), Consejo Superior de Investigaciones Cientificas (Spain), European Centre for Medium-Range Weather Forecasts (UK), Fundació Privada Institut Català de Ciències del Clima (Spain), Institut Pasteur de Dakar (Senegal), International Livestock Research Institute (Kenya), Kwame Nkrumah University of Science and Technology (Ghana), Universitaet zu Koeln (Germany), University Cheikh Anta Diop de Dakar (Senegal), University of Liverpool (UK), University of Malawi (Polytechnic & College of Medicine), University of Pretoria (South Africa)

Sleeping dragon: African trypanosomosis

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African trypanosomosis is a deadly disease that affects millions of people and livestock in sub-Saharan Africa. Will this disease decrease in importance over the coming years, or will it continue its devastation?
 
The current and future importance of African trypanosomosis was one of many issues discussed by a group of experts from veterinary, medical and associated professions who met at the International Livestock Research Institute (ILRI) in Nairobi in early June for two back-to-back scientific workshops. The Doyle Foundation workshop was held 6-7 June 2006 followed by the Wellcome Trust-funded Host-Pathogen workshop 8-9 June.
 

The purpose of the Doyle Foundation workshop on African trypanosomosis was to take a broader view of the human and animal health aspects of African trypanosomosis and to initiate an analysis of the current/future importance of the disease, control strategies/options, research gaps, future directions and opportunities for investment.


New science can lead to new opportunities, particularly for building synergies between approaches to animal and human forms of  African trypanosomosis. Considerable work is being undertaken by a wide range of specialists – but this work is often undertaken in isolation of other experts in other disciplines. As the number of zoonotic diseases increases, the lines between medical and veterinary sciences will become increasingly blurred and there are many opportunities to share knowledge within and between disciplines and sciences.

The Doyle Foundation Chair Gabrielle Persley opened the first workshop with the following observations: ‘African trypanosomosis is a neglected disease. It is endemic in large areas of sub-Saharan Africa and causes great losses and hardship. This meeting is the beginning of a broader consultation that aims to identify the researchable issues and facilitate new multidisciplinary partnerships that can contribute to improving the well-being and productivity of people and livestock in Africa.’

Terry Pearson from the University of Victoria, in Canada, referred to African trypanosomosis as a sleeping dragon. ‘It sleeps for long periods, then reawakens and flares into an epidemic. There have been two major sleeping sickness epidemics in the past 120 years, each of which killed nearly a million people. Recently, the Sleeping Dragon has re-awoken to create yet another epidemic, with about 60 million people in sub-Saharan Africa at risk.’

A May 2006 article in PLoSMedicine1 pointed out that neglected tropical human diseases, as a group, have joined the ranks of the ‘big three’ (HIV/AIDS, tuberculosis and malaria) to create a 21st century ‘gang of four’. African trypanosomosis is one of five neglected diseases that as a group are responsible for 400,000 human deaths annually. Each year, trypanosomosis causes approximately 48,000 human deaths and the loss of 1.5 million life-years due to premature disability. In addition, Africa each year loses up to US$5 billion due to animal trypanosomosis.

Who will slay Africa’s Sleeping Dragon?
More than 50 scientists from a wide range of specialties participated in the workshops, to discuss a common interest – the elusive African trypanosome parasite, the cause of the disease.

The Doyle Foundation workshop was attended by twenty young local scientists. Among these was Deo Mdumu Birungi, a graduate fellow from the Ugandan Ministry of Agriculture studying for a PhD in animal breeding and genetics at ILRI in Nairobi: ‘This has been a fantastic opportunity. It was exciting to spend two days with such a distinguished group. Normally young scientists don’t get to participate in such workshops. I have learned so much. It has encouraged me to think deeper about my area.’

It was not just the young scientists who benefited. Jayne Raper from New York Medical School stated: ‘I have been studying trypanosomes for over twenty years. This was the first time that I have had to think about the livestock angle! It has been totally stimulating. I will go back home with new perspectives and strongly urge that more interdisciplinary meetings like this be held.’

John Donelson, from the University of Iowa, and Chair of the Wellcome Trust-funded Trypanosomosis Consortium workshop, said: ‘This has been hugely educational for all. There has been a superb mix of people and building of synergies. Most importantly, there have been some fantastic outputs that have exceeded all our expectations.’

In her concluding remarks, the Doyle Foundation’s Chair Gabrielle Persley said:  ‘Although these meetings are only the first step, we have already witnessed the exploration of potential new partnerships. The experts in attendance believe that African trypanosomosis continues to be important and that better and more integrated controls need to be devised and delivered. To continue the dialogue, we will be organizing further consultations – our virtual consultation will begin immediately and a further meeting is planned for late 2006, where additional experts in relevant scientific areas will be invited to participate.’

Further information
Copies of all presentations from the Doyle Foundation meeting are available at:
http://www.biosciencesafrica.org/Biosciences_Africa_DF_Tryps_Workshop_June2006.htm

The Doyle Foundation African Trypanosomosis Workshop Program



Wellcome Trust-funded African Trypanosomosis Host Pathogen Consortium: Information Sheet

Terry Pearson’s Opening Address: The Long Journey of the African Trypanosome

Film Shows produced by Doyle Foundation/Clare Kemp:

Tom Randolph interviews John McDermott on African trypanosomosis


Doyle Foundation Chair, Gabrielle Persley describes the importance of African trypanosomosis


Recent Related Articles/News

The problem with African trypanosomosis
This is perhaps best summed up in the words of an African subsistence farmer, quoted by one of the presenters at a recent International Scientific Council for Trypanosomiasis Research and Control meeting:

‘My child is dying of malaria, but it is African trypanosomiasis that is killing us.’

Source: World Health Organisation. Workers on African trypanosomiasis unite. TDR News. No 76. March 2006. Read the full article at: http://www.who.int/tdr/publications/tdrnews/news76/tryps.htm.

New research highlights the importance of treating cattle in the battle against sleeping sickness
According to an article in New Agriculturist, recent research findings suggest a new approach to tackling sleeping sickness that could reverse a deteriorating situation in Uganda.

‘As well as focusing on the disease in people, we could also treat cattle. Treatment of the disease in cattle is relatively simple and cost-effective with drugs and insecticides, which can eliminate the disease from the animal population and therefore prevent its spread.

‘Field trials have recently been completed which suggest that, if 86% of cattle were treated with drugs that kill the rhodesiense parasites, we could eliminate the animal reservoir. If there are no parasites in cattle, there will be no new cases of human sleeping sickness.

Source: New Agriculturist. The need to control sleeping sickness. Perspective by Dr William Olaho-Mukani. 1 July 2006.

References:
1Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, Sachs JD. (2006). Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3(5): e102.