Wellcome Trust, Science seek to stem upsurge in animal disease emergencies hitting developing countries

Researchers are converging in Cambridge, UK, to find ways of translating research findings faster into pro-poor animal health policy and practice.
 
Rift Valley fever, which continues to spread in East Africa, killing more than 90 people in Kenya alone, brings into sharp focus the inadequacies of animal health delivery systems in developing countries and the role of the global community in redressing these. This mosquito-transmitted disease is also hurting the livelihoods of poor people by killing their young cattle and sheep and causing ‘abortion storms’ in their pregnant stock.

Brian Perry, a veterinary epidemiologist at the Nairobi-based International Livestock Research Institute (ILRI), argues today (19 January 2007) in Science, a leading scientific journal, that animal diseases impeding livestock enterprises in developing countries are being ignored by the global community, leaving developing countries stranded with outmoded disease control systems that serve neither the needs of the poor nor the global community. In his article, ‘Science for Development: Poverty Reduction through Animal Health’, Perry and co-writer Keith Sones argue that the global community needs to give greater thought and investment to building scientific capacity in animal health research within developing countries.

Perry’s article explores opportunities afforded by science to help resolve this mismatch. Perry also points out high-priority areas requiring new funding. The article sets the tone for a high-level conference on animal health research taking place in Cambridge, UK, next week, at which Dr Perry and other ILRI colleagues will be presenting their research findings to an international group of experts. The conference is co-sponsored by the Wellcome Trust (UK) and Science.

To obtain the article by Brian Perry, ‘Science for Development: Poverty Reduction through Animal Health’ (Science, Vol. 315. no. 5810, pp. 333–334), please contact the American Association for the Advancement of Science (AAAS) at +1 202-326-6440 or scipak@aaas.org. Or get the article online (subscription required) at: http://www.sciencemag.org/cgi/content/summary/315/5810/333.

For interviews, contact Catherine Mgendi at +254 20 422 3035 or cell: +254 726 243 046; c.mgendi@cgiar.org.
Or contact Brian Perry direct at +254 20 422 3000; b.perry@cgiar.org

Innovative and collaborative veterinary organizations make vaccine available to Kenyan livestock keepers

A group of determined Kenyan livestock keepers set in motion an innovative collaboration that has benefited cattle-keeping communities throughout Kenya
 
Starting in 2000, word started getting out among Kenyan pastoralists that a vaccine being administered in Tanzania was succeeding in protecting cattle against East Coast fever. Kenya at that time did not condone use of this vaccine due to perceived safety and other issues, and so Kenya ’s livestock keepers could not get hold of it. In response, they began to walk their calves across the Kenya border into Tanzania to get them vaccinated.

‘East Coast fever is responsible on average for half of the calf mortality in pastoral production systems in eastern Africa . This vaccine represented a much needed lifeline for many pastoralists, and livestock keepers in Kenya wanted access to it,’ Evans Taracha, head of animal health at at ILRI explained.

‘ILRI faced a dilemma. We had produced a vaccine right here in Nairobi, at the International Livestock Research Institute (ILRI), that could protect pastoral and other cattle against East Coast fever, but, due to government regulations, our beneficiaries could not get access to it in Kenya.’

Kenya’s livestock keepers then started lobbying national authorities and called upon Vétérinaires sans Frontières (VSF)-Germany, an international veterinary NGO based in East Africa , to help them. Thus began a highly successful multi-partner collaboration.

Besides VSF-Germany, the collaboration includes ILRI, the Kenyan Agricultural Research Institute (KARI), the African Union-InterAfrican Bureau for Animal Resources (AU/IBAR), the Director of Veterinary Services (DVS), the NGO VetAgro, and the community-based Loita Development Foundation.

Gabriel Turasha, field veterinary coordinator for VSF-G said, ‘The demand for this vaccine was evident from the farmers’ actions. What we needed to prove – to the authorities restricting its use – was that the vaccine was safe, effective and a superior alternative to the East Coast fever control strategy already being used in Kenya .’

Armed with scientific evidence, the collaboration successfully lobbied the Kenyan government and then facilitated local production and local access to the vaccine. Three vaccine distribution centres have been established in Kenya and more than 10,000 calves vaccinated.

John McDermott, ILRI’s deputy director general of research, said, ‘This collaboration illustrates how the research from “discovery to delivery” can be facilitated by collaboration between research institutes, which are in the business of doing science, and development partners, which are in the business of on-the-ground delivery. This has been a great success story—and a great win for Kenya ’s pastoralists.’

This innovative collaboration has been selected as a finalist in the Consultative Group on International Agricultural Research (CGIAR) ‘Innovation Marketplace Awards’. These awards recognize outstanding collaborative efforts among CGIAR-supported centres and civil society organizations. Four winners will be announced at the CGIAR’s Annual General Meeting, to be held in Washington, DC , in December 2006.

Carlos Seré, director general of ILRI, said, ‘We are delighted to learn that this partnership has received recognition. ILRI is involved in a host of innovative collaborations and continues to seek new partners—from civil society organizations to the private sector to local research institutions—to help us deliver on our promises to poor livestock keepers in developing countries.’

ollaborative Team Brings Vaccine against Deadly Cattle Disease to Poor Pastrolists for the First Time

Related Articles on Innovation Collaborations
ILRI recently collaborated with VSF-Belgium, VSF-Switzerland and two Italian NGOs in an Emergency Drought Response Program in Kenya.

VSF, ILRI, Italian NGOs, and Kenya Collaborate to Mitigate the Effects of Drought in Northern Kenya

The ILRI collaborative effort described in this Top Story was featured in the Journal of International Development (July 2005) as an example of a ‘potentially new model of research and development partnership’ with a more ‘complete’ approach to innovation.

 

Further Information
VSF-Germany is a nongovernmental, not-for-profit organization engaged in veterinary relief and development work. VSF-Germany's primary role involves the control and prevention of epidemics; the establishment of basic veterinarian services and para-veterinarian programs with high involvement of local people; the improvement of animal health, especially among agriculturally useful animals; food security through increases in the production of animal-based food and non-food products; and the reduction of animal diseases that are transferable to humans. VSF-Germany carries out emergency as well as development operations. The organization's area of operation is East Africa.

Website: http://www.vsfg.org/eng.php

Battling bird flu: Taking developing countries and their contexts into account is an imperative for success

Fighting deadly bird flu in the developing world is more complex and difficult than in the industrialized west. To be effective, global control strategies must take developing-country contexts and perspectives into account.

A recent consultation on highly pathogenic avian influenza (HPAI) highlighted the complexities of fighting bird flu in the South. The consultation, held in Nairobi 14–16 June 2006, was organized by the International Livestock Research Institute (ILRI) and the International Food Policy Research Institute (IFPRI). Participants worked towards identifying how the research community can best assist developing countries and frontline personnel in the fight against bird flu both now and in the medium to longer terms.

 

The consultation report, How Research Can Support Efforts to Control Avian Influenza in Developing Countries: First Steps Toward a Research Action Plan, is now available. The report contains a comprehensive list of service and research needs identified by participants. The next step will involve validating and prioritizing these lists in a broader email-based consultation.

Battling Bird Flu: Developing Country Context & Perspectives
Developing countries have large numbers of widely dispersed small-scale and backyard poultry keepers. This makes detecting and controlling the disease difficult. In addition, these countries generally have insufficient numbers of professional in disease control and communication work and insufficient institutional support for controlling disease. All of this makes it difficult to communicate the risks of the disease and to get people to comply with control efforts. ‘Stamping-out’ (mass culling of poultry infected or suspected to be infected) is routinely adopted in industrialized countries, but this approach is likely to be impractical in developing countries. If our strategies to fight bird flu don’t take developing-country contexts into account, we will fail to control bird flu globally.

As important, John McDermott, ILRI’s Deputy Director General for Research, warns, ‘In the battle against bird flu, the world’s poorest people could become the main victims of the disease. They have little voice in how we control the disease and the burden of controlling it falls disproportionately on the rural poor, who both consume their own poultry and rely on it for their livelihoods.’

McDermott and his colleagues at ILRI and partner institutions in Africa and Asia are saying, in effect, that ‘one size does not fit all’. What works in the North will not necessarily work in the South. To fight bird flu successfully, we must attend to social as well as to economic and technical issues, we must learn from frontline experience, and we must understand the developing-country context for disease control. If we do these things, we will help develop control strategies that countries can tailor to their conditions and circumstances.

The Consultation: Experiences from the Front Line
The Nairobi Consultation opened with interviews of scientists with direct field experience in Asia and Africa. These experts with first-hand knowledge of fighting the disease identified illegal cross-border trade and live bird markets as key vehicles for the spread of bird flu within and between countries. Constraining early notification of disease outbreaks and subsequent control of the disease, they reported, were insufficient or total lack of compensation for lost birds, lack of trust in governments, and the common  farmer experience of losing lots of birds to Newcastle Disease and other, endemic, diseases.

Key Issues Highlighted
Compensation

  • Well-publicized and carefully thought out compensation plans are critical to achieving early notification of outbreaks and effective control of bird flu. Lessons from the front-line tell us that compensation plans should consider more than just direct compensation for birds lost to the disease or culling operations. While some countries have provided poultry owners with compensation, others have not done so or do not intend to offer any form of compensation. A key message from the experts at this consultation was that compensation matters, and it matters a great deal to millions of poor small-scale farmers.
  • In India, for example, although farmers received compensation within a few hours of their birds being culled, they were compensated for no associated investments. Many farmers had cash tied up in grain bought to feed their chickens and had no other use for the grain once their chickens were gone. India’s experience suggests that a broader view of compensation is required. The bird flu scare in India caused people to panic, poultry prices plummeted, and those directly and indirectly involved with poultry and grain lost their livelihoods as their industry crashed.
  • Implementing different compensation levels for different sizes and/or ages of birds lost could create new problems. Farmers might be tempted, for example, to hide their young birds until they grew to a size that would attract the highest price, thus putting people and animals at greater risk of the disease.


Major threats

  • Migrating birds: Many participants believed that migrating wild birds were not the greatest threat to the spread of bird flu in developing countries. Although southern Africa had not at the time of the consultation had any confirmed cases of the highly pathogenic H5N1 virus, different forms of bird flu have been present there for some years, typically infecting ostriches. Experts there are concerned about possible introduction of new strains from ostriches and introduction by illegal cross-border movement of people, birds, and avian products, as well as the wild birds who migrate from nothern Europe to this region.

 

  • Trade: Illegal cross-border transfers of both live poultry and carcasses was identified as one of the biggest threats to the spread of bird flu and a key route for transmission within and between countries. Live birds and poultry carcasses are already being smuggled across borders and this is likely to increase if widespread culling is implemented and little or no compensation is offered. The borders of many developing countries are large and porous with only certain parts patrolled, making illegal cross-border transportation of birds relatively easy.
  • Markets: Live bird markets represent another key route for transmission of bird flu. In some countries, farmers are being advised not to take home any live birds that they are unable to sell at market to avoid infecting flocks at home, but what they should do with their live unsold birds is not specified. And where live bird markets are being made illegal, some are simply going underground.


Diagnosis and control

  • Poor farmers are familiar with dead and dying chickens – this is a fairly regular occurrence for them. Newcastle disease is endemic in many developing countries and can kill many birds fast. Confusion in the diagnosis of poultry diseases – notably in distinguishing the Newcastle disease from HPAI and other diseases  – is a further obstacle to early notification and identification of bird flu. Needed are clear communication and information about the physical signs and symptoms of poultry diseases, what to do if the farmer sees these, and the risks the farmer faces if he or she does nothing about the disease.
  • People’s lack of trust in their governments and/or promises of compensation were identified as key constraints to implementing emergency response and control procedures such as mass culling. The utility of employing mass culling as a means to control the spread of bird flu in developing countries was also questioned by these experts.
  • Most smallholders keep only a few birds in their backyards. Mass culling of all poultry infected and suspected to be infected would be impractical. If no incentives are provided to the smallholders for complying with culling operations, and if most of the smallholders do not recognize the risks of not culling, it is likely that many of them would simply hide their chickens or try to sell them quickly. The incentives provided to poultry keepers have to be sufficient to encourage people to be extra vigilant and to report any suspected cases of bird flu immediately.


Poultry to human transmission

  • Many poor people live close to their livestock, with household members and their chickens often sharing the same small dwelling at night. This increases the potential for transmission of bird flu from poultry to humans. How do you educate people about the dangers of poultry-to-human transmission when practices such as sleeping in the same room with your chickens are widespread? What alternatives do people living in great material poverty have that will ensure their poultry are safe from predators or theft?


The value of chickens to the poor

  • For many small farmers, chickens are ‘coins’ in the bank used for small emergencies: the birds can be sold quickly to raise money for such essentials as food, school fees and medicines.
  • Chicken and eggs are relatively cheap sources of animal protein for the poor. If eggs and chicken become unavailable to the poor, the nutrition and health of many children, women of childbearing age, and other vulnerable groups will be put at risk.
  • Poor people value chickens for more than their market value. For many, chickens represent the first step on the ‘livestock ladder’ out of poverty. Compensation schemes based on market rates are thus unlikely to satisfy farmers or provide them with sufficient incentive to report suspected cases of bird flu.


Alternative investment strategies

  • If chickens are culled and people advised not to restock, what livestock can replace the chickens? Larger livestock are out of the reach of many poor people. And even financial compensation at market values for a small number of chickens would be insufficient to enable the poor to reinvest in other types of livestock. Thus, the living assets of the poor would be liquidized with few alternative (livestock) reinvestment options on offer; other livelihood options would have to be explored.


Information, education and communication

  • Information, Education and Communication has been the mantra working well in Vietnam, one of the first countries to suffer from bird flu. Vietnam has been continually developing, refining and improving its communications to make them relevant to the local communities.
  • Many communications concerning bird flu have been written in English and/or other European languages and do not translate well into local languages. To be effective, communications must consider social and cultural contexts and be open to continual revisions.
  • The bird flu outbreak in Laos highlighted the lack of basic science education and lack of veterinary infrastructure. No veterinarians had been trained there since 1975, leaving only nine veterinarians to serve the whole country. Laos is now working hard, however, to build capacity. The bird flu outbreaks in Laos were largely in commercial poultry farms in urban areas and there were only a few commercial poultry farmers with large numbers of birds. This is in stark contrast to other developing countries in Asia and Africa, where the poultry structure is made up of very large numbers of widely distributed small commercial operations.
  • Community and religious leaders were identified as key players to raise awareness of the dangers of bird flu. Having a series of clear, simple messages conveyed in local languages to communities by trusted sources was viewed as vital to preparedness, emergency response and control. Community action worked well in communities that were relatively stable, and where people were regularly informed and involved and had a vested interest in working together to protect the community as a whole.


According to Dr Carlos Seré, ILRI’s Director General: ‘The global fight against bird flu has to equitable as well as effective – protecting the livelihoods of the world’s poor as well as lives worldwide.

‘To be more effective, efficient and sustainable, bird flu control technologies and strategies must be adapted to the particular realities and constraints of developing countries, including the need to balance public health and poverty reduction objectives. Otherwise, bird flu control will not work in developing countries, and poor control there will continue to threaten the North.’

Short Movie
Robyn Alders of the Kyeema Foundation on The difficulties of diagnosing bird flu in developing countries.

Sleeping dragon: African trypanosomosis

African trypanosomosis is a deadly disease that affects millions of people and livestock in sub-Saharan Africa. Will this disease decrease in importance over the coming years, or will it continue its devastation?
 
The current and future importance of African trypanosomosis was one of many issues discussed by a group of experts from veterinary, medical and associated professions who met at the International Livestock Research Institute (ILRI) in Nairobi in early June for two back-to-back scientific workshops. The Doyle Foundation workshop was held 6-7 June 2006 followed by the Wellcome Trust-funded Host-Pathogen workshop 8-9 June.
 

The purpose of the Doyle Foundation workshop on African trypanosomosis was to take a broader view of the human and animal health aspects of African trypanosomosis and to initiate an analysis of the current/future importance of the disease, control strategies/options, research gaps, future directions and opportunities for investment.


New science can lead to new opportunities, particularly for building synergies between approaches to animal and human forms of  African trypanosomosis. Considerable work is being undertaken by a wide range of specialists – but this work is often undertaken in isolation of other experts in other disciplines. As the number of zoonotic diseases increases, the lines between medical and veterinary sciences will become increasingly blurred and there are many opportunities to share knowledge within and between disciplines and sciences.

The Doyle Foundation Chair Gabrielle Persley opened the first workshop with the following observations: ‘African trypanosomosis is a neglected disease. It is endemic in large areas of sub-Saharan Africa and causes great losses and hardship. This meeting is the beginning of a broader consultation that aims to identify the researchable issues and facilitate new multidisciplinary partnerships that can contribute to improving the well-being and productivity of people and livestock in Africa.’

Terry Pearson from the University of Victoria, in Canada, referred to African trypanosomosis as a sleeping dragon. ‘It sleeps for long periods, then reawakens and flares into an epidemic. There have been two major sleeping sickness epidemics in the past 120 years, each of which killed nearly a million people. Recently, the Sleeping Dragon has re-awoken to create yet another epidemic, with about 60 million people in sub-Saharan Africa at risk.’

A May 2006 article in PLoSMedicine1 pointed out that neglected tropical human diseases, as a group, have joined the ranks of the ‘big three’ (HIV/AIDS, tuberculosis and malaria) to create a 21st century ‘gang of four’. African trypanosomosis is one of five neglected diseases that as a group are responsible for 400,000 human deaths annually. Each year, trypanosomosis causes approximately 48,000 human deaths and the loss of 1.5 million life-years due to premature disability. In addition, Africa each year loses up to US$5 billion due to animal trypanosomosis.

Who will slay Africa’s Sleeping Dragon?
More than 50 scientists from a wide range of specialties participated in the workshops, to discuss a common interest – the elusive African trypanosome parasite, the cause of the disease.

The Doyle Foundation workshop was attended by twenty young local scientists. Among these was Deo Mdumu Birungi, a graduate fellow from the Ugandan Ministry of Agriculture studying for a PhD in animal breeding and genetics at ILRI in Nairobi: ‘This has been a fantastic opportunity. It was exciting to spend two days with such a distinguished group. Normally young scientists don’t get to participate in such workshops. I have learned so much. It has encouraged me to think deeper about my area.’

It was not just the young scientists who benefited. Jayne Raper from New York Medical School stated: ‘I have been studying trypanosomes for over twenty years. This was the first time that I have had to think about the livestock angle! It has been totally stimulating. I will go back home with new perspectives and strongly urge that more interdisciplinary meetings like this be held.’

John Donelson, from the University of Iowa, and Chair of the Wellcome Trust-funded Trypanosomosis Consortium workshop, said: ‘This has been hugely educational for all. There has been a superb mix of people and building of synergies. Most importantly, there have been some fantastic outputs that have exceeded all our expectations.’

In her concluding remarks, the Doyle Foundation’s Chair Gabrielle Persley said:  ‘Although these meetings are only the first step, we have already witnessed the exploration of potential new partnerships. The experts in attendance believe that African trypanosomosis continues to be important and that better and more integrated controls need to be devised and delivered. To continue the dialogue, we will be organizing further consultations – our virtual consultation will begin immediately and a further meeting is planned for late 2006, where additional experts in relevant scientific areas will be invited to participate.’

Further information
Copies of all presentations from the Doyle Foundation meeting are available at:
http://www.biosciencesafrica.org/Biosciences_Africa_DF_Tryps_Workshop_June2006.htm

The Doyle Foundation African Trypanosomosis Workshop Program



Wellcome Trust-funded African Trypanosomosis Host Pathogen Consortium: Information Sheet

Terry Pearson’s Opening Address: The Long Journey of the African Trypanosome

Film Shows produced by Doyle Foundation/Clare Kemp:

Tom Randolph interviews John McDermott on African trypanosomosis


Doyle Foundation Chair, Gabrielle Persley describes the importance of African trypanosomosis


Recent Related Articles/News

The problem with African trypanosomosis
This is perhaps best summed up in the words of an African subsistence farmer, quoted by one of the presenters at a recent International Scientific Council for Trypanosomiasis Research and Control meeting:

‘My child is dying of malaria, but it is African trypanosomiasis that is killing us.’

Source: World Health Organisation. Workers on African trypanosomiasis unite. TDR News. No 76. March 2006. Read the full article at: http://www.who.int/tdr/publications/tdrnews/news76/tryps.htm.

New research highlights the importance of treating cattle in the battle against sleeping sickness
According to an article in New Agriculturist, recent research findings suggest a new approach to tackling sleeping sickness that could reverse a deteriorating situation in Uganda.

‘As well as focusing on the disease in people, we could also treat cattle. Treatment of the disease in cattle is relatively simple and cost-effective with drugs and insecticides, which can eliminate the disease from the animal population and therefore prevent its spread.

‘Field trials have recently been completed which suggest that, if 86% of cattle were treated with drugs that kill the rhodesiense parasites, we could eliminate the animal reservoir. If there are no parasites in cattle, there will be no new cases of human sleeping sickness.

Source: New Agriculturist. The need to control sleeping sickness. Perspective by Dr William Olaho-Mukani. 1 July 2006.

References:
1Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, Sachs JD. (2006). Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3(5): e102.

Poultry maps prepared for fight against bird flu: Higher resolution maps urgently needed

Africa is now fighting bird flu literally in its backyards. Seven countries have now confirmed they have the deadly H5N1 virus in their poultry populations.

These are Nigeria, Egypt, Niger, Cameroon, Burkina Faso, Sudan and Côte d'Ivoire. Egypt has reported Africa's first cases of human infections, (13 to date) which have killed five people.

Worldwide, bird flu has hit 46 countries, killed 115 people, caused some 200 million birds to be killed at a cost of around 20 billion US dollars, and ruined the livelihoods of millions of smallholder farmers whose livelihoods depend on poultry keeping.

From 2003 to 2005 the virus was reported in 15 countries. But in the first four months of this year, it moved rapidly to 31 new countries, with major outbreaks in Turkey, Iraq, Israel, Gaza, Afghanistan, Pakistan, Myanmar and India as well as the seven African states.

The World Health Organization (WHO) is working with the United Nations Food and Agriculture Organization (FAO) and the World Organisation for Animal Health (OIE) to improve veterinary services that, in many of the affected countries, have been under-resourced for decades.

Dr David Nabarro, the UN's chief coordinator for avian influenza underscored the importance of using veterinary services to fight bird flu and the world's other emerging diseases of a communicable kind, '70 percent of which come from animals', he said.

What ILRI is doing to help its neighbours and partners fight bird flu
Like many of its partner organizations in livestock research for development, the Africa-based International Livestock Research Institute (ILRI) has been pooling its resources to contribute to the fight against this deadly disease. An internal task force is working on a number of fronts.

Several ILRI staff members sit on national avian influenza task forces set up in ILRI's hosting countries of Kenya and Ethiopia and are advising on the design of research support to control efforts in Nigeria. (Kenya's preparedness plan is considered one of the best in the developing world.) These ILRI staff are providing their veterinary and research expertise to advise on surveillance, monitoring diagnosis and control programs established to prevent or control the disease in poultry.

ILRI scientists are also preparing studies intended to generate practical information for immediate use by authorities, veterinarians and the public. These studies will compare different control strategies and assess their impacts on the poor and assist governments to prepare action plans for surveillance, control and containment of outbreaks. In longer term research, ILRI and its partners have proposed exploring the genetic make-up of chickens to unravel attributes influencing infection and transmission of the highly pathogenic form of avian influenza in various breeds.

Bird flu consultation to be held in Nairobi
In addition, ILRI and its sister Future Harvest Centre, the International Food Policy Research Institute (IFPRI), are convening a consultation of interested partners from the international research community to explore ways in which research can support efforts to control highly pathogenic avian influenza. This scientific consultation will focus on the needs of developing countries and their poor populations of poultry keepers, sellers and consumers. The meeting will be held at ILRI's Nairobi headquarters, probably in early June (dates will be confirmed shortly).

Participants at the meeting will respond to requests ILRI, IFPRI and other research institutions are receiving from donor organizations. Donors want to know how to target their bird flu research investments so as ensure that those investments support effective control of the disease while minimizing the negative impacts on the poor. ILRI is also assembling a team to undertake a rapid appraisal of past experiences in controlling bird flu. Because implementing conventional response strategies against bird flu in many developing countries can be problematical and may place particular hardship on the poor, many of whom rely on poultry for their livelihoods, this rapid research study aims to synthesize lessons learned and identify strategies that may offer more 'nuanced' means of controlling the disease while protecting the livelihoods of the poor.

Poultry maps are prepared for the battle against bird flu


Global livestock maps

In 2002, ILRI produced livestock density maps (see Mapping Poverty and Livestock in the Developing World by Thornton et al., ILRI, 2002) derived from new analyses locating major populations of poor people (including poor livestock keepers), assessing how these populations are likely to change over the next half century, and showing estimated populations of different types of livestock around the world.

African and global chicken maps
In recent weeks, using data sets provided by the Food and Agriculture Organization of the United Nations (FAO), ILRI prepared Africa and global maps of chicken densities. These maps are being used to determine areas under greatest threat and to help those countries already afflicted to target their disease control efforts.

Although the FAO-derived maps are based on the world's best information, they should be treated as indicative only; we caution against their over-interpretation (see Background Information below). This kind of macro-level analysis, while useful as a starting point, hides enormous variability, and thus can be dangerous if relied upon as a sole source of information. Ultimately, the fight against bird flu in Africa has to be conducted at much higher resolutions of basic information. (For an editorial on our lack of sufficient information, see Nature's Dreams of flu data. As the Nature editorial puts it, 'We have better data on galaxies 10 billion light years away than on human cases of avian flu in China or Vietnam.')

As ILRI agricultural systems analyst Philip Thornton, who headed ILRI's global livestock and poverty mapping project, says, 'The collation, maintenance and dissemination of baseline data is seldom supported in the agriculture sector. But in many ways, this data work is crucial to agricultural development and poverty alleviation. Information on livestock numbers and breeds in our African livestock databases is remarkably poor. Moreover, it seems clear that bird densities have to be assessed at relatively high resolution, given the heterogeneity involved.'

The maps do illustrate, however, the wide extent of 'backyard' chicken keeping in Africa—and thus the likely ubiquitous nature of any adverse impacts on the poor stemming from the appearance of bird flu or programs implemented to control it. The African and global chicken maps underscore the need to vastly upscale efforts to collect and improve our baseline information on poultry keeping. Indeed, the poverty of our information on poultry keeping in Africa is one of the biggest challenges facing agencies committed to fighting the new scourge.


 

Global Chicken Density


The chicken density map for Africa, below, represents a snapshot of chicken distribution for the mid- to late 1990s at sub-national level. The white areas on the map represent areas that have no reported livestock numbers available. Despite limited data, this map gives an indication of the enormous threat bird lu poses to sub-Saharan Africa.


 

Africa Poultry Map

Uganda poultry map
With 2002 household data from the Uganda Bureau of Statistics, ILRI produced in March 2006 high-resolution poultry maps for Uganda. The maps give important details on densities of local chickens, exotic chickens, ducks, geese and guinea fowl. Most local chickens are reared in the northeastern region and there is a high density of exotic chickens around major urban centres—Kampala, Jinja, Entebbe, Masaka, Mpigi and Mbarara—where demand has outstripped supply of local chickens. To view the Uganda maps, see ILRI's previous Top Story, Bird Maps for Uganda.

 


ILRI Top Story, 4 April 2006
 

One world, one health

Holistic approaches to controlling the 'perfect storm' of health problems in poor countries, particularly Africa's catastrophic disease burden, must include better control of diseases transmitted between animals and people.

A paper to be published this May 2006 in the Public Library of Science (PLoS) journal PLoS Medicine, a peer-reviewed open-access journal (available online at www.plosmedicine.org) advocates linking integrated work on ‘neglected’ tropical diseases with major global health partnerships recently formed to tackle the three most devastating diseases of the poor: malaria, TB and AIDS. The authors of the paper, which include development economist Jeffrey Sachs, argue that while new partnerships and initiatives have significantly raised funding and awareness of the need to scale up the fight against the ‘big three’ diseases, conspicuously absent is work on a group of ‘neglected tropical diseases’ that may threaten the poor as much as malaria, TB and AIDS and for which there are already cheap and effective control strategies. The authors propose that our success in controlling the big three may depend on a concurrent attack on this group of neglected diseases, which include three vector-borne protozoan infections (leishmaniasis, human African trypanosomosis and Chagas disease), three bacterial infections and seven kinds of helminth (worm) infections.

The potential benefits of taking a more holistic approach to disease control are being popularized in complementary initiatives advocating ‘one health’ strategies that simultaneously address human and animal health. (See, for example, a new book exploring grass roots ideas from East and Southern Africa on how to integrate wildlife, livestock and human health for both conservation and development: ‘One World, One Health’ is available online from LEAD, the Livestock, Environment and Development Initiative.

ILRI supports these holistic health approaches and further argues that another class of neglected diseases of the poor—‘zoonotic’ diseases, or those transmitted between people and animals—should be included. Zoonotic diseases account for a remarkable 75% of all human diseases and include such emerging diseases as avian influenza. Esther Schelling, a veterinary epidemiologist on joint appointment with the International Livestock Research Institute (ILRI) and the Swiss Tropical Institute, points out that zoonotic diseases are virtually excluded from most health initiatives ‘because they’re simply not accounted for’. ILRI is helping to ensure that they are accounted for and that methods to control them are friendly to the poor.

Two papers on this topic by Schelling and colleagues are available online:
British Medical Journal article
Lancet article

Carlos Seré, director general of ILRI, says that with the sequence in recent years of BSE (‘mad cow disease’), foot-and-mouth disease, and now bird flu, there is definitely increasing interest in zoonotic diseases.

‘Donors like the Welcome Trust’, he says, ‘are increasing their investment in tropical animal disease research. Our own strategy is to develop appropriate methods for researchers and policy-makers to evaluate the risk of these zoonotic diseases and together identify the most promising strategies and policies that can help to reduce such risk, particularly for the poor. We have activities specifically looking at zoonoses such as brucellosis and bovine TB, and we are building up our expertise in food safety issues. Strengthening our expertise on food safety and the risks posed by zoonoses is central to two of ILRI’s strategic research themes, the first on sustaining lands and livelihoods which involves protecting human health, and the second on improving livestock-related market opportunities in domestic and international markets, which are increasingly threatened by such food safety concerns.’

In relation to bird flu, Dr Seré explains, ‘ILRI will not be the virologists or poultry specialists. But we have comparative strength in systems analysis, which combines social science with epidemiology and animal genetics and other lab bench research to address complex health problems. We do this in conjunction with partners who bring more specific expertise, such as in poultry or vaccines. What we specifically bring to the picture is a “poverty lens” to understand the implications of health problems, issues and control strategies on the poorest populations in the world.’

‘Clearly, research is not a “rapid deployment tool”’, he says. ‘There are other organizations—such as the World Health Organisation (www.who.org), the Food and Agriculture Organization of the United Nations (www.fao.org), and the World Animal Health Organisation (www.oie.org) —that have a regulatory mandate and policy responsibility and are linked directly to governments. ILRI’s comparative advantage is in the longer term: in understanding the issues and in providing sound technical research to back these agencies which are doing the short-term response work. As we see more and more that boundaries don’t work, that disease is a global problem, we encourage industrialized countries to share their resources with developing countries, not just out of enlightened self-interest, but also, for example, to ensure food safety for their domestic consumers. And finally, we are particularly interested in helping developing countries to build their own research capacity to understand, model and control complex disease problems.

ILRI vaccine advances published in February 2006 PNAS journal

Public-private partnership makes major step towards improving livestock health and reducing poverty.

The devastating effects of East Coast fever on the livelihoods of small-scale farmers may one day be a thing of the past as a team of international scientists moves closer towards the development of a vaccine.

“East Coast fever is an intractable problem that ravages cattle of the poor in Africa. The good news is that this can be solved by high-tech science and technological innovations, achievable through strategic partnerships’’. Evans Taracha – ILRI East Coast Fever Vaccine Project Leader

Every year, East Coast fever destroys the small farmer’s dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National Academy of Sciences (PNAS), shows how genomics can generate pivotal new vaccines.

In the study, scientists from five institutions, including the International Livestock Research Institute (ILRI) and The Institute for Genomic Research (TIGR), identify five vaccine targets, or candidate proteins that could form the basis for an East Coast fever subunit vaccine. Based on combined bioinformatics analyses and lab tests, these proteins appear to provide a protective immune response to the disease. “This initiative took just three years, after many years of scientists trying other methods,” remarks Vishvanath Nene, former ILRI staff member, a study author and molecular biologist at TIGR. “It’s a huge jump forward.”

To make the jump, researchers used the genome sequence of the parasite responsible for East Coast fever. A tick-borne parasite, Theileria parva, causes the disease. When ticks infected with T. parva bite cattle, they transmit the parasite, launching the disease that typically kills cattle within a month. In July, 2005, TIGR led a research team that published T. parva’s genome sequence, representing roughly 4,000 genes, in Science.

In the current study, Nene, along with Malcolm Gardner and Claire Fraser-Liggett, also of TIGR, relied on known biology to search T. parva’s genome for potential vaccine proteins. First, scientists know that immunity to the parasite, and thus East Coast fever, emerges from immune system cells known as killer T cells. Second, they know that T. parva is an intracellular pathogen–it infects and secretes proteins inside cattle white blood cells, which become malignant. The white blood cell then unwittingly passes small fragments of the secreted parasitic proteins associated with a certain type if its own proteins along to its cell surface. And this is where a vaccine could come in: A vaccine made of the T. parva proteins found on the surface of host cells should trigger an immune response in cattle. Vaccinated cattle would then be protected from the parasite.

To find potential vaccine antigens, the TIGR researchers scanned T. parva’s entire genome for genes that make secreted proteins. In particular, they searched for genes that make a “secretion signal,” a telltale peptide sequence found at the start of secreted proteins. Sure enough, the scientists found some 400 T. parva genes containing the secretion signal. This set of genes provided a starting pool of candidate proteins. Based on further tests, the study’s research team, led by ILRI of Nairobi, Kenya, cloned 55 candidate antigen genes and screened those genes for response by killer T cells taken from cattle immune to East Coast fever. To complement TIGR’s gene selection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates.

In total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T cells. Going a further step further, the scientists inoculated cattle with these antigens and then gave the cattle a potentially lethal dose of T. parva. When compared with control animals, vaccinated cattle showed significantly stronger immune response to the parasite.

“This study is a true milestone,” says Fraser-Liggett, president of TIGR. “It’s one of the first to take advantage of genomic technologies and build a test vaccine using immune killer T cells as a screening reagent.” In addition to TIGR and ILRI, the research team included scientists from: the Ludwig Institute for Cancer Research in Brussels; the Wellcome Trust Center for Human Genetics in Oxford; Sanofi Pasteur in Toronto; the University of Edinburgh; and Merial SAS, an international animal health company. ILRI and Merial have partnered to develop a vaccine against East Coast fever.

By using genomics to understand and fight T. parva, scientists may make advances against related parasites that cause malaria, tuberculosis, and other diseases in which killer T cells also play a role in immunity. What’s more, because T. parva launches a cancer-like illness inside the white blood cells of cattle, it may provide a model system for understanding the mechanics of cancer biology.

But for Nene, who was born in Kenya and worked at ILRI for 15 years before coming to TIGR in 2001, the march against East Coast fever is significant reward, itself. “This disease takes an enormous toll on the local society and economy of rural areas across eastern and central Africa, including Maasai and other pastoral communities,” he says. In particular, East Coast fever kills cattle kept by families trying to rise out of poverty. If researchers are successful, Nene notes, the entire region will have new reason to hope for a better life. Evans Taracha, ILRI project leader, also highlights the importance of strategic research partnerships to overcome this and similar diseases.

TIGR’s portion of the PNAS study was funded independently by TIGR and by sub-contract from the Animal Health Program of the United Kingdom Department for International Development, with previous contributions from J. Craig Venter and the ILRI for the T. parva genome project.

ILRI scientist Simon Graham wins international ‘Promising Young Scientist’ award

Young scientist receives prestigious award at the Consultative Group on International Agricultural Research (CGIAR)'s annual general meeting.


Simon Graham Award

Simon receives his awardSimon Graham, a veterinary immunologist at the Nairobi-based International Livestock Research Institute (ILRI), was bestowed the ‘Promising Young Scientist Award’ by the Consultative Group on International Agricultural Research (CGIAR) on 7 December 2005 by Ian Johnson, CGIAR Chairman and World Bank Vice President for Sustainable Development. This prestigious award was presented at the annual general meeting of the CGIAR, held in Marrakech, Morocco.

The award went to 33-year-old Graham for his research leading to the development of a sensitive and robust system for screening molecules that cause East Coast fever (ECF), a fatal disease of cattle in sub-Saharan Africa. Graham’s research, based at ILRI’s Nairobi laboratories, may also contribute to ongoing efforts to control tropical theileriosis, a cattle disease which puts 250 million cattle around the world at risk.

Simon Graham Dec 2005 During his first post-doctoral position at the Centre for Tropical Veterinary Medicine, Edinburgh, UK, in 1998, he developed an improved rapid screening and production of vaccines against the protozoan parasite Theileria annulata, which is responsible for tropical theileriosis.

In 2000, Graham joined a large multidisciplinary research team at ILRI whose goal is to develop a ‘subunit’ Simon At Workvaccine against the related protozoan parasite Theileria parva. (Subunit vaccines are based on molecular bits of parasites rather than whole parasites.) T. parva causes East Coast fever (ECF), which costs 11 countries of eastern, central and southern Africa US$300 million a year. ECF puts 28 million cattle at risk and annually kills 1 million animals, 90 percent of which are kept by poor dairy farmers and herders. There is a high demand from poor livestock owners for a cheap, effective, safe and easy-to-deliver subunit vaccine against this devastating disease of cattle.

Simon Graham and his ILRI team are working in collaboration with several centres of excellence, including the veterinary pharmaceutical giant Merial and a leading human vaccine research group at the University of Oxford, UK, to evaluate the ability of these molecules to protect cattle against ECF. Initial results are encouraging—there appears to be a significant association between an animal’s induction of killer T-cell responses and its levels of protection against development of disease. Graham’s results have within a short space of time had a major impact in moving the research close to its ultimate goal of producing a vaccine that will sustainably control not only ECF but also tropical theileriosis. The vaccine candidates identified by Graham have been filed with the US Patent & Trademark Office and the research is now being prepared for publication in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

New outbreak of fatal Rift Valley fever in the Horn of Africa

Rift Valley fever is a viral disease of people and ruminant animals transmitted by mosquitoes. Epidemics frequently present as extensive abortion storms in small ruminants and cattle combined with heavy mortality in young animals. In people, the disease is most often a febrile illness without serious consequences. In a low percentage of human cases (about 1% or less), hemorrhagic complications can arise. Blindness also occasionally results. 118 deaths have been confirmed since the outbreak in November 2006 in the North-eastern province and coastal region of Kenya.

The disease is transmitted by the bite of infected mosquitoes or heavy exposure to aerosols in situations such as the slaughtering of infected animals. Outbreaks of the disease are associated with changes in local water resource management or periods of heavy rainfall. Examples have been the construction of new dams or El Nino rain events such as the one in East Africa in 1997-98 when there was a major outbreak of Rift Valley fever in Kenya and Somalia. The virus has been shown to over-winter in infected mosquito eggs. At the onset of the rains, infected mosquitoes transmit the disease to suitable amplifying hosts such as small ruminants. If vector densities are sufficiently high due to favourable environmental conditions, this starts a cascade-like recrudescence of the virus in the host and vector populations, leading to an epidemic.

Severe human cases, although an infrequent outcome of infection, are often the event that triggers recognition that an epidemic is under way.  There is need to develop early warning systems and to validate prevention and control strategies that can mitigate the evolution of outbreaks. Rift Valley fever causes serious economic losses in livestock particularly in cattle and sheep, although goats, camels, Asian water buffalo and wild antelopes may be vulnerable.

Key research questions

A number of important research questions related to Rift Valley fever and its impact remain unanswered and worthy of further research.  These include the following:

•  What is the economic impact of an RVF outbreak, particularly in terms of distribution, livelihoods, international trade, public health, and other macro-level factors?  How does the disease affect unrelated sectors (e.g., tourism)?
•  How has the disease broadly affected trade patterns in livestock products from the horn of Africa and what are potential future impacts? How can these be mitigated?
•  How effective are current vaccines in their ability to prevent disease and how frequent are side effects? There are two types of vaccines currently in use, both of which have serious disadvantages.  For human use, a ‘killed vaccine’consists of formalin-inactivated virus for restricted use.   It requires several doses and annual revaccination.  It is not approved for general distribution and is used only for laboratory workers and other specialized groups.  A live, attenuated vaccine is approved for use in livestock.  It induces a solid, life-long immunity but may cause abortions if administered to pregnant animals. 
•  What is the epidemiological impact and cost-effectiveness of alternative types of vaccination and movement control strategies?  How can these tools be best used in the face of outbreaks like the one we are experiencing now?
•  Can diagnostic tests for the disease be improved to make them more ‘user-friendly’ for field workers and remote laboratories?  Is it possible to develop good diagnostic tests to distinguish between active and past infections, and to distinguish previously exposed animals from vaccinated animals?
•  How can we enhance decision-making and promote the application of risk-based standards to ensure safe international trade of livestock products and scientifically sound trade restrictions?

 The Nairobi-based International Livestock Research Institute (ILRI) is actively seeking to become engaged in two areas.

In diagnostics, ILRI recently held discussions with the Kenya’s Department of Veterinary Services and South Africa’s Onderstepoort Veterinary Institute (OVI).  OVI have developed a field-based test to diagnose RVF infection in cattle.  This test requires only the application of a small blood sample to the device with a result obtained in about three minutes.  Such a test has advantages over a laboratory-based test, in terms of speed of diagnosis and no need for electricity or other equipment.  Although the test has profed successful in the laboratory, it has yet to undergo extensive testing in the field to ensure that it is sufficiently accurate.  It is envisaged that ILRI will be involved in this testing, using samples from the current outbreak.

On another front, ILRI is pursuing the possibility of working with a Walter Reed Project (WRP) and the US-based Centers for Disease Control (CDC) to support their ongoing efforts to understand and control this present outbreak of Rift Valley Fever.  Internal discussions within ILRI highlight three key areas in which ILRI could contribute in this process:

• Sensitise key stakeholders, particularly in government of the epidemiological and economic magnitude and impact of the current outbreak in Kenya.
• Initiate a process to identify appropriate veterinary control strategies to reduce both animal   and human incidence of the disease
• Take advantage of the current situation to collect key epidemiological and economic data to guide further research and improve risk mitigation tools

ILRI is in discussions with the WRP-CDC teams to define roles specific for ILRI in the areas of assessing the socio-economic impacts of the disease, participatory epidemiology and surveillance, and the interface between livestock and public health.  ILRI aims to help WRP-CDC in their short-run emergency response efforts as well as to use this current outbreak to help design decision-support tools to better manage future occurrences of Rift Valley Fever.

CDC expert updates Kenya on Avian Influenza

Kenyan CDC expert Dr Kariuki Njenga tells of Kenya's preparedness for bird flu. "The best way to manage the threat is to control the disease at its source – in birds."

Dr Kariuki Njenga, a Kenyan expert working with the International Emerging Infections Programme in the Kenya office of the US Center for Diseases Control (CDC), delivered a seminar on avian influenza to staff of the International Livestock Research Institute (ILRI) at their Nairobi headquarters on Thursday, 25 November 2005.

Dr Njenga said that the influenza viruses are some of the most intriguing and elusive in the world. Special characteristics of the highly pathogenic avian flu virus strain known as H5N1 increase the likelihood that there will be increased emergence of chimeric (new) viruses, one or more of which could cross over to humans and be transmitted from human to human and cause a flu pandemic.

Increased associations between animals and people, Dr Njenga said, especially in Southeast Asia, is providing a conduit for the avian influenza virus to come into contact with people as they handle dead or dying infected birds. Most of the 122 human cases of the disease, with 62 deaths, so far reported to the World Health Organization have occurred on backyard farms where poultry are kept.

‘Our main concern right now in Kenya and other countries in Africa along the migratory bird flyways’, said Dr Njenga, ‘are backyard chicken farmers’. More than three-quarters of Kenyans are rural farmers and it is estimated that more than 90 percent of them keep chickens. The fear is that wild birds infected with the deadly H5N1 virus strain now migrating to Kenya for the European winter might come in contact with domestic water birds, such as ducks, which then might contact free-scavenging chickens kept by poor rural people, and so the virus could be passed from birds to people. If this happens, the country would have to act within 21 days to contain the infection to prevent the outbreak spreading wide.

ILRI and CDC staff are part of a national task force that has been assembled in Kenya to deal with bird flu. This task force is providing early warning of bird die-offs and strengthening surveillance nationwide, developing a communications network and stock-piling anti-virals so that these are on handle to contain any outbreak. There is no effective vaccine to prevent a pandemic caused by the H5N1 flu strain.

The task force is instructing Kenyans to note any sick or dead birds. They should report these to veterinary or government authorities or they may collect dead birds in plastic bags, using plastic bags to protect their hands as they do so, and take them to their local veterinary officer.
 

Increasing developing-country livestock trade without increasing disease

Livestock sellers in Mozambique

Are there opportunities for greater trade of livestock products from developing countries without increasing the risk of spreading animal diseases?

A new study from the International Livestock Research Institute (ILRI) and the Food and Agriculture Organization of the United Nations (FAO) suggests that there are and lays out a series of recommendations as to how they might be achieved. Livestock is one of the key assets of most developing countries, but compared to other agricultural products, this resource is currently significantly underutilised as a tool for poverty reduction. One of the reasons behind this is that many developing countries still harbour animal diseases that present a risk to the West, where diseases such as foot and mouth disease (FMD) and classical swine fever (CSF), to name but two, have been eradicated. Their reintroduction to countries free of these diseases has disastrous economic and environmental consequences. This dichotomy presents yet another example of the widening divide between developed and developing countries. So how can developing countries make better use of their livestock resources through greater market access in the world without putting developed countries at greater risk? This topic has been the subject of a study recently undertaken by ILRI on behalf of FAO, the report of which was released in July 2005.

Entitled ‘An appropriate level of risk: balancing the need for safe livestock products with fair market access for the poor’, the report questions some of the ground rules for safe international trade in livestock commodities, while at the same time identifying specific needs for human resource capacity development to safeguard the animal health and food safety integrity of livestock commodity value chains. Led by ILRI’s veterinary epidemiologist Brian Perry, the study identified some market successes, and some failures, in the regions of South East Asia, eastern and southern Africa and Central America, drawing from them some key lessons of global significance.

Read the complete report: http://www.fao.org/ag/againfo/programmes/en/pplpi/docarc/wp23.pdf