Category Archives: Disease Control

Under vaccines, we develop vaccines for livestock diseases, focusing especially on ways to improve immune responses to protozoa parasites. We also improve existing vaccines (ECF, CBPP) and develop molecular approaches to problems.

ILRI board member Dieter Schillinger awarded Wilhelm-Pfeiffer Medal for his contribution to veterinary medicines

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Dieter Schillinger

Dieter Schillinger, member of the board of trustees of the International Livestock Research Institute (ILRI), has been awarded the 2010 Wilhelm-Pfeiffer Medal of the Justus-Liebig University in Giessen, Germany, to honour his 'outstanding contribution and service to promote research and innovation in veterinary medicines'.

The medal is awarded annually by the German university's faculty of veterinary medicine to people who have provided outstanding services to veterinary medicine. Schillinger, a doctor of veterinary medicine, received the award on 16 July 2010 during a graduation ceremony at Justus-Liebig University.

German-born Schillinger is based in Lyon, France, where he has served the pharmaceutical company Merial as Head of Public Affairs for Europe, Middle East and Africa since 2006. He is responsible for government relations and the management of Merial’s activities in the political and public policy arenas. Merial is a world-leader in animal health with a proven track record in producing pharmaceutical products and vaccines for livestock, pets and wildlife.

For further information, please see the following news release (in German).

New project to reduce chicken disease in Ethiopia

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Chicken on LUO RU BIN's farm

A new study of genetic resistance to disease in Ethiopia’s indigenous chicken breeds is scheduled to start later this year. In collaboration with the Ethiopian Institute for Agricultural Research, the University of Liverpool, Roslin Institute, the Univerisity of Edinburgh and the University of Nottingham, researchers from the International Livestock Research Institute (ILRI) will seek to identify ‘the causes of infectious diseases that have a major impact on poultry production in Ethiopia.’

Scheduled to start in September 2010, the study will take place in the district of Jarso, in eastern Ethiopia, and in Horro, in the west of the country. The results of this research will be linked to an ongoing poultry breeding program to improve resistance to ‘priority infectious diseases’ and thereby enhance the productivity of the country’s poultry sector.

Poultry play important economic, nutritional and socio-cultural roles in the livelihoods of poor rural households in Ethiopia and many other developing countries, where birds are widely integrated into smallholder production systems and help households cope with hunger and poverty.

Buying and rearing poultry is often a first step out of poverty. Women tend to own and manage chickens, usually native chicken varieties, which provide them with their only independent source of cash income.

Although breeding programs for local chickens have shown that rapid improvement in productivity is possible, researchers have yet to identify and select the optimal breeds for improving, by, for example, providing resistance to common infectious diseases.

Tadelle Dessie, a team leader of ILRI’s biotechnology theme in Ethiopia, and one of the leaders of the chicken project, says ‘enhanced genetic resistance through selective breeding is still an under-exploited low-cost opportunity for disease control in low-input poultry production systems’. He says the study will investigate genetic variability in the resistance of local chicken ecotypes to major infectious diseases hurting village poultry production in Ethiopia. Results of the research will inform strategies for improving both disease resistance and productivity.

Indigenous chicken varieties are well adapted to local environments, but local birds tend to grow slowly and produce fewer and smaller eggs than commercial varieties. Infectious diseases, however, can wipe out flocks of exotic, higher-producing, poultry.

Knowledge from this study should enable Ethiopian policymakers and animal health professionals to design more precise disease-control plans. The study itself should help improve Ethiopia’s scientific capacity in this field by training local scientists and enhancing laboratory facilities for poultry testing.

Staff are now being recruited for the project, which will be launched in September.

New participatory initiative to involve local communities in disease control

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A new approach to disease surveillance and control aims to unite human and animal medical approaches to better control disease spread and so improve public health.

In this 10-minute film from the International Livestock Research Institute (ILRI), representatives of seven institutional members of a Participatory Epidemiology Network for Animal and Public Health (PENAPH), which includes researchers from ILRI, discuss ways of involving communities and health workers in the process of empowering local people.

The network uses participatory approaches to come up with effective ways of dealing with community challenges and encourages teamwork among farmers, veterinarians, nurses, doctors, governments and other specialists, especially in setting up effective disease surveillance systems.

Research shows bird flu still a threat to poultry production in Kenya

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Chicken

Risk assessment shows Avian Influenza still a threat to poultry production in Kenya

The risk of avian flu on poultry production continues to be a threat to the livelihoods of many poor and livestock-reliant farmers in developing countries such as Kenya, researchers say.

Scientists from the International Livestock Research Institute (ILRI) and the International Food Policy Research Institute (IFPRI) have found that poultry farmers in Kenya are ‘highly susceptible to the introduction and spread of the highly pathogenic avian influenza (HPAI)’ because of the country’s location along key wild birds’ migratory routes and the absence of strong mechanisms to deal with a possible outbreak of the disease.

Like in many developing countries, poultry production is an important livelihood activity in Kenya. Most poultry is kept by small-scale farmers in non-commercial settings, who depend on income from the sale of eggs, animals and meat to sustain their livelihoods.

Results from a 2009 impact assessment conducted by ILRI, IFPRI and the Royal Veterinary College in London with support from the Department for International Development (DFID) on the ‘Role of Poultry in Kenyan Livelihoods and the Ex Ante Impact Assessment of HPAI on Livelihood outcomes’ show that farmers in the key poultry producing regions of the country are not adequately prepared to deal with an outbreak of avian influenza.

Though the country has not had an outbreak of avian flu, there were two scares in 2005 and 2005.  The scares led to a slowdown in the industry as farmers, in fear of making losses, reduced flock sizes by up to 40 per cent. The two scares also led to a depressed market for poultry and poultry products and lowered the prices which negatively impacted farmers. The assessment showed that farmers in Kenya are still at risk especially because the country’s human and animal health services are not adequate. Coupled with the fact that most of the poultry farming in the country is a ‘backyard poultry system’ preventing and controlling disease outbreaks would be significantly difficult.

Among others, the results of the assessment also showed, like other studies had confirmed, that poultry production is largely done by women and children to support livelihoods and that most of the poultry in Kenya is produced in the country’s western and eastern regions. Farmers in these places are most at risk of loses in the event of a HPAI outbreak. Kenyan farmers keep an average flock size of 18 birds across the country but there are significant variations across regions mostly determined by ease of access to markets. Nairobi province, for example, has large producers (though fewer in number compared to other regions) with an average of 158 birds per flock because of access to ready market for their animals.

The assessment found that ‘households with “larger” small-scale flocks as well as those located in high risk areas (Western, Nyanza and parts of Eastern provinces) are vulnerable to HPAI.  In the event of an outbreak, the disease would cause ‘significant reduction in livestock income and wealth (asset value) and total annual household income would be reduced.’

The results of this assessment were first published as ‘The role of poultry in Kenyan livelihoods and the ex ante impact assessment of HPAI on Livelihood outcomes’ by the International Food Policy Research Institute (IFPRI).  A full report of the assessment can be found in the following link http://www.ifpri.org/sites/default/files/publications/hpairb11.pdf

For more information visit www.hpai-research.net


Livestock goods and bads: Filmed highlights of ILRI’s 2010 Annual Program Meeting

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At the 2010 Annual Program Meeting (APM) of the International Livestock Research Institute (ILRI), held in April in Addis Ababa, Ethiopia, several hundred participants debated and discussed the challenges facing the global livestock industry. ILRI and its partners are investigating ways to promote smallholder participation in livestock markets, more sustainable ways for livestock keepers to use natural resources, and ways to improve livestock pathways out of poverty.

Some of the presentations made during the meeting on the theme of 'Livestock: the Good, the Bad and the Gaps' were captured on film. We share three of those below.

The first film is a presentation by ILRI agricultural systems analyst Mario Herrero on the important place of livestock for smallholder farmers in developing economies. Herrero highlights the many benefits livestock bring to the rural poor and argues that the rapidly expanding sector will need to be better managed and to reduce the environmental risks it poses if it is to continue to be productive. Herrero argues for an integrated assessment of the effects of the global livestock industry on various agro-ecosystems important to the poor.

In the second film, ILRI veterinary and food safety researcher Delia Grace discusses the human health risks associated with livestock keeping. Grace notes that zoonotic diseases (those transmitted between animals and people) and emerging infectious diseases (such as bird flu) are two of the well-known risks associated with livestock. But she says that animals provide a means of regulating diseases because they can serve as sentinels that lets communities and public health officials know of disease outbreaks before the diseases can affect humans. She makes the case for more research to address the many common misconceptions that exist about livestock and human health.

In the third film, Narayan Hedge, of India's BAIF Development Research Foundation, highlights the important role livestock play in providing a livelihood for nearly 700 million people in India. He makes an appeal for better livestock technologies, better infrastructure, and more efficient management of the industry so that more smallholder farmers can use livestock to escape poverty.

Livestock vaccine offers lifeline to many

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ITM Vaccine

A vaccine is being made available to save the lives of a million cattle in sub-Saharan Africa against a lethal disease and to help safeguard the livelihoods of people who rely on their cattle for their survival.

East Coast fever is a tick-transmitted disease that kills one cow every 30 seconds. It puts the lives of more than 25 million cattle at risk in the 11 countries of sub-Saharan Africa where the disease is now endemic. The disease endangers a further 10 million animals in regions such as southern Sudan, where it has been spreading at a rate of more than 30 kilometres a year. While decimating herds of indigenous cattle, East Coast fever is an even greater threat to improved exotic cattle breeds and is therefore limiting the development of livestock enterprises, particularly dairy, which often depend on higher milk-yielding crossbred cattle. The vaccine could save the affected countries at least a quarter of a million US dollars a year.

Registration of the East Coast fever vaccine is central to its safety and efficacy and to ensuring its sustainable supply through its commercialization. The East Coast fever vaccine has been registered in Tanzania for the first time, a major milestone that will be recognized at a launch event in Arusha, northern Tanzania, on May 20. Recognizing the importance of this development for the millions whose cattle are at risk from the disease, governments, regulators, livestock producers, scientists, veterinarians, intellectual property experts, vaccine distributors and delivery agents as well as livestock keepers – all links in a chain involved in getting the vaccine from laboratory bench into the animal – will be represented.

An experimental vaccine against East Coast fever was first developed more than 30 years ago at the Kenyan Agricultural Research Institute (KARI). Major funding from the UK Government’s Department for International Development (DFID) and others enabled work to produce the vaccine on a larger scale. When stocks from 1990s ran low, the Africa Union/Interafrican Bureau for Animal Resources and chief veterinary officers in the affected countries asked the International Livestock Research Institute (ILRI) to produce more and ILRI subsequently produced a million doses of the vaccine to fill this gap. But the full potential for livestock keepers to benefit from the vaccine will only be achieved through longer term solutions for the sustainable production, distribution and delivery of the vaccine.

With $28US million provided by the Bill & Melinda Gates Foundation and DFID, a not-for-profit organization called GALVmed (Global Alliance for Livestock Veterinary Medicines) is fostering innovative commercial means for the registration, commercial distribution and delivery of this new batch of the vaccine. A focus on sustainability underpins GALVmed’s approach and the Global Alliance is bringing public and private partners together to ensure that the vaccine is available to those who need it most.

Previous control of East Coast fever relied on use of acaracide dips and sprays, but these have several drawbacks. Ticks can develop resistance to acaracides and regular acaricide use can generate health, safety and environmental concerns. Furthermore, dipping facilities are often not operational in remote areas.

This effective East Coast fever vaccine uses an ‘infection-and-treatment method’, so-called because the animals are infected with whole parasites while being treated with antibiotics to stop development of disease. Animals need to be immunized only once in their lives, and calves, which are particularly susceptible to the disease, can be immunized as early as 1 month of age.

Over the past several years, the field logistics involved in mass vaccinations of cattle with the infection-and-treatment method have been greatly improved, due largely to the work of a private company, VetAgro Tanzania Ltd, which has been working with Maasai cattle herders in northern Tanzania. VetAgro has vaccinated more than 500,000 Tanzanian animals against East Coast fever since 1998, with more than 95% of these vaccinations carried out in remote pastoral areas. This vaccination campaign has reduced calf mortality in herds by 95%. In the smallholder dairy sector, vaccination reduced the incidence of East Coast fever by 98%. In addition, most smallholder dairy farmers reduced their acaracide use by at least 75%, which reduced both their financial and environmental costs.

Notes for Editors

What is East Coast fever?
East Coast fever is caused by Theleria parva (an intracellular protozoan parasite), which is transmitted by the brown ear tick Rhipicephalus appendiculatus. The parasites the tick carries make cattle sick, inducing high fever and lympho-proliferative syndrome, usually killing the animals within three weeks of their infection.

East Coast fever was introduced to southern Africa at the beginning of the twentieth century with cattle imported from eastern Africa, where the disease had been endemic for centuries. This introduction caused dramatic cattle losses. The disease since then has persisted in 11 countries in eastern, central and southern Africa – Burundi, Democratic Republic of Congo, Kenya, Malawi, Mozambique, Rwanda, Sudan, Tanzania, Uganda, Zambia and Zimbabwe. The disease devastates the livelihoods of small-scale mixed crop-and-livestock farmers, particularly smallholder and emerging dairy producers, as well as pastoral livestock herders, such as the Maasai in East Africa.

The infection-and-treatment immunization method against East Coast fever was developed by research conducted over three decades by the East African Community and the Kenya Agricultural Research Institute (KARI) at Muguga, Kenya (www.kari.org). Researchers at the International Livestock Research Institute (ILRI), in Nairobi, Kenya (www.ilri.org), helped to refine the live vaccine. This long-term research was funded by the UK Department for International Development (DFID) (www.dfid.gov.uk) and other donors of the Consultative Group on International Agricultural Research (CGIAR) (www.cgiar.org).

The first bulk batch of the vaccine, produced by ILRI 15 years ago, has protected one million animals against East coast fever, with the survival of these animals raising the standards of living for many livestock keepers and their families. Field trials of the new vaccine batch, also produced at ILRI, were completed in accordance with international standards to ensure that it is safe and effective.

How is the vaccine stored and administered?
Straws of the East Coast fever vaccine are stored in liquid nitrogen until needed, with the final preparation made either in an office or in the field. The vaccine must be used within six hours of its reconstitution, with any doses not used discarded. Vaccination is always carried out by trained veterinary personnel working in collaboration with livestock keepers. Only healthy animals are presented for vaccination; a dosage of 30% oxytetracycline antibiotic is injected into an animal’s muscle while the vaccine is injected near the animal’s ear. Every animal vaccinated is given an eartag, the presence of which subsequently increases the market value the animal. Young calves are given a worm treatment to avoid worms interfering with the immunization process.

Note
Case studies illustrating the impact of the infection-and-treatment vaccine on people’s lives are available on the GALVmed website at: www.galvmed.org/path-to-progress
For more information about the GALVmed launch of the live vaccine, on 20 May 2010, in Arusha, Tanzania, go to www.galvmed.org/

US$4.4 million awarded for research to build a climate model able to predict outbreaks of infectious disease in Africa

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Cow suffering from trypanosomosis

Scientists at the University of Liverpool, in the UK, and the International Livestock Research Institute (ILRI), in Kenya, are working with 11 other African and European partners on a US$4.4-million (UK£3 million-) project to develop climate-based models that will help predict the outbreak and spread of infectious diseases in Africa.

The researchers are working to integrate data from climate modelling and disease-forecasting systems so that the model can predict, six months in advance, the likelihood of an epidemic striking. The research, funded by the European Commission Seventh Framework, is being conducted in Ghana, Malawi and Senegal. It aims to give decision-makers the time needed to deploy intervention methods to stop large-scale spread of diseases such as Rift Valley fever and malaria, both of which are transmitted by mosquitoes.

It is thought that climate change will change global disease distributions, and although scientists know a lot about the climate triggers for some diseases, they don’t know much about how far into the future these disease events can be predicted. This new project brings together experts to investigate the links between climate and vector-borne diseases, including ‘zoonotic’ diseases, which are transmissible between animals and humans.

ILRI veterinary researcher Delia Grace says that diseases shared by people and animals are under-investigated although they are critically important for public health. ‘Fully 60% of all human diseases, and 75% of emerging diseases such as bird flu, are transmitted between animals and people,’ she said.

ILRI geneticist Steve Kemp said that the project is making use of ILRI’s advanced genomics capacities to analyse pathogens from the field and to integrate the data collected on both pathogen distribution and climatic factors. ‘From ILRI’s point of view,’ Kemp said, ‘this project is particularly exciting because it brings strong climate and weather expertise that complements systems recently built by ILRI and its partners to detect outbreaks of Rift Valley fever and to determine its spread.’

The new project also complements ILRI’s ongoing work to better control trypansomosis in West African livestock, a disease transmitted by tsetse flies. Trypanosomosis, which is related to sleeping sickness in humans, causes devastating losses of animals—along with animal milk, meat, manure, traction and other benefits—across a swath Africa as big as continental USA. Members of the new modeling project will conduct research in some of the same locations as ILRI’s West African trypanosomosis project, Kemp explained, and work with some of the same partner organizations, which should generate synergies that benefit both projects.

The risk of epidemics in tropical countries increases shortly after a season of good rainfall—when heat and humidity allow insects, such as mosquitoes, to thrive and spread diseases. Matthew Baylis, from Liverpool’s School of Veterinary Science, explained how this works with Rift Valley fever: ‘Rift Valley fever can spread amongst the human and animal population during periods of heavy rain, when floodwater mosquitoes flourish and lay their eggs. If this rainfall occurs unexpectedly during the dry season, when cattle are kept in the villages rather than out on the land, the mosquitoes can infect the animals at the drinking ponds. Humans can then contract the disease by eating infected animals. Working with partners in Africa, we can bring this information together to build a much more accurate picture of when to expect epidemics.

Andy Morse, from Liverpool’s School of Environmental Sciences, said the project combines historical and contemporary climate data with disease incidence information, including that for vector-borne diseases, as well as integrating monthly and seasonal forecasts. The resulting single, seamless, forecast system, Morse said, should allow projections of disease risk to be made beyond the conventional predictable time limit. ‘All this information will be fed into a decision-support system to be developed with decision-makers on national health issues’ in the three target countries.

The project was launched at a conference at the University of Liverpool on 19 April 2010.

For more information, contact ILRI scientist Steve Kemp. ILRI email contacts are formatted as follows: f.surname@cgiar.org: replace ‘f’ with the staff member’s first initial and replace ‘surname’ with the staff member’s surname.

The 13 research partners:
Abdus Salam International Centre for Theoretical Physics (Italy), Centre de Suivi Ecologique (Senegal), Consejo Superior de Investigaciones Cientificas (Spain), European Centre for Medium-Range Weather Forecasts (UK), Fundació Privada Institut Català de Ciències del Clima (Spain), Institut Pasteur de Dakar (Senegal), International Livestock Research Institute (Kenya), Kwame Nkrumah University of Science and Technology (Ghana), Universitaet zu Koeln (Germany), University Cheikh Anta Diop de Dakar (Senegal), University of Liverpool (UK), University of Malawi (Polytechnic & College of Medicine), University of Pretoria (South Africa)

Biologists in Nairobi to take part in two new animal health projects announced this week by the US National Science and Gates foundations

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East Coast Fever

The National Science Foundation (NSF) of the United States announced on 12 May 2010 that the Foundation, in partnership with the Bill & Melinda Gates Foundation, is awarding 15 grants worth US$20 million in support of basic research for generating sustainable solutions to big agricultural problems in developing countries.

These are the first grants in a new five-year Basic Research to Enable Agricultural Development (BREAD) program, which is jointly funded by NSF and the Gates Foundation.

The awards in this first year of funding will allow leading scientists worldwide to work together in basic research testing novel and creative approaches to reducing longstanding problems faced by smallholder farmers in poor countries.

Scientists from the Nairobi, Kenya, animal health laboratories of the International Livestock Research Institute (ILRI) will participate in 2 of the 15 projects selected among the many submitted to BREAD for funding.

Biologists at New York and Michigan State universities and Regeneron Pharmaceuticals (USA), the Roslin Institute and the University of Edinburgh (UK) and ILRI (Kenya) will test a novel approach to developing cattle that are resistant to trypanosomosis, a deadly cattle disease that is closely related to sleeping sickness in humans and that holds back animal agriculture across a swath of Africa as large as continental USA.

In another project, scientists from the University of Vermont and Plum Island Animal Disease Center (USA) will work with the University of Copenhagen (Denmark) and ILRI on use of advanced genetics to develop vaccines for East Coast fever and other cattle diseases that threaten the livelihoods of millions of smallholder farmers in sub-Saharan Africa.

Go here for a 12 May 2010 news release from the US National Science Foundation: http://www.nsf.gov/news/news_summ.jsp?cntn_id=116932

A complete list of 2010 BREAD awards can be accessed at: http://www.nsf.gov/bio/pubs/awards/bread10.htm

Livestock research at ILRI: A view from the North

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Dieter SchillingerDieter Schillinger joined the board of trustees of the International Livestock Research Institute (ILRI) in 2009. This week he attended his second meeting of the board, held in Addis Ababa, Ethiopia.

He first got to know one of ILRI's forebears, the International Laboratory for Research on Animal Diseases (ILRAD), in the 1980s. He was then head of a German project developing new pharmaceuticals for trypanosomosis, a tsetse-borne disease that causes major problems for Africa’s livestock farmers. ‘We didn't have any success for trypanosomosis in cattle, but we did better with camels,’ he recalls, ‘and I still think of myself as a “camelophile”’.

A veterinarian by training, he now works as head of public affairs for Merial, one of the world's largest animal health companies, and chairs the Food Chain Committee of the International Federation for Animal Health.

One of the first things to impress Schillinger at ILRI was the broad range of interests represented on the board. ‘This came as a welcome surprise,’ he explains, adding that ILRI is a very different beast to ILRAD. ‘ILRAD was very focused on animal health research, whereas ILRI has a more balanced approach, integrating a range of different research activities related to livestock farming,’ he explains.

According to Schillinger, ILRI has an important role to play not just in providing solutions to the problems facing livestock farmers in the developing world, but in alerting people in the North to the importance of animal health issues. ‘Nowadays, everybody in Europe—politicians, the public, nongovernmental organizations—looks at livestock from the point of view of animal welfare,’ he says. ‘That's a good thing, but without good animal health, you don't have good animal welfare, and the research conducted by ILRI is therefore leading to better animal welfare.’

Schillinger also believes that ILRI's research can provide significant benefits for human health in the North. ‘Here’s an institution that’s working on diseases in Africa that could spread to Europe, including zoonotic diseases that can be transmitted from livestock to humans,’ he says. With the increase in travel and trade, and the likely effects of global warming, the risk of diseases spreading from one continent to another has risen.

‘If we can control livestock diseases in Africa, they are less likely to spread, and I think there will be more funds for this sort of research in the future,’ he says. ILRI can legitimately claim to be conducting research that benefits not only the rural poor in Africa but also the wealthier populations in the North.

East Coast fever vaccine comes to market in eastern and southern Africa

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As the board of trustees of the International Livestock Research Institute (ILRI) meets in Addis Ababa, Ethiopia, this week, reviewing ILRI’s animal health research among other work, an ILRI vaccine project is highlighted in a new publication, DFID Research 2009–2010: Providing research evidence that enables poverty reduction. The UK Department for International Development (DFID) and the Bill & Melinda Gates Foundation both support the Global Alliance in Livestock Veterinary Medicines (GALVmed), which works to convert existing or near-market technologies into livestock medicines and vaccines for use in developing countries. The notable success of this strategy in 2009, says DFID, is an East Coast fever vaccine produced by ILRI. East Coast fever is a tick-transmitted disease that kills one cow every 30 seconds in eastern, central and southern Africa, where it threatens some 25 million cattle in 11 countries and is now putting at risk a further 10 million animals in new regions, such as southern Sudan, where the disease has been spreading at a rate of more than 30 kilometres a year. The disease is a major cattle killer. In herds kept by the pastoralist Maasai, it kills 20–50% of all unvaccinated calves, which makes it difficult and often impossible for the herders to plan for the future or to improve their livestock enterprises. A vaccine for East Coast fever could save over a million cattle and up to £170 million a year in the 11 countries where the disease is now endemic. An experimental vaccine against East Coast fever, which makes use of live but weakened parasites, has existed for more than three decades, with batches mass produced in ILRI’s Nairobi laboratories. Although constrained by the need for a ‘cold chain’ to keep the ‘live’ vaccine viable, field use of this vaccine in Tanzania and elsewhere has proved it to be highly effective and in demand by poor livestock keepers, who are paying for the vaccine to keep their animals alive. GALVmed has worked with ILRI and private companies, such as VetAgro Tanzania Ltd., to make East Coast fever vaccine available to the livestock keepers who need it most and to scale up production in future. With £16.5 million provided by DFID and the BMGF, GALVmed began working on the registration and commercial distribution and delivery of a new batch of the vaccine produced by ILRI. The vaccine was successfully registered in 2009 in Malawi and Kenya, with Tanzania and Uganda expected to follow soon. If it is approved in Uganda, it will be the first veterinary vaccine formally registered in that country. GALVmed is now working to establish viable commercial production and delivery systems, aiming that by the end of 2011, all aspects of the production and delivery of East Coast fever vaccine are in private hands.

Scottish and Kenyan research groups collaborate to improve control of deadly cattle disease in Africa

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ITM Vaccine New project launched to investigate how immunity develops in cattle to fatal diseases caused by different strains of tick-borne parasites

More than 1 in 5 people in sub-Saharan Africa live below the poverty line. Many of these people live in rural communities heavily dependent on livestock for their livelihoods. One of the most important diseases of cattle in this region is East Coast fever, a lethal infection of cattle caused by the tick-borne parasite Theileria parva. This disease afflicts cattle populations in 16 countries across eastern, central and southern Africa and is the most economically important cattle disease in 11 of these countries. Losses due to East Coast fever exceed US$300 million annually. Imported high-yielding breeds of cattle, which are increasingly being used to satisfy increasing demands for milk in this region, are particularly susceptible to this disease.
Although East Coast fever can be controlled by treating infected animals with anti-parasitic drugs and by regularly spraying or dipping animals with anti-tick chemicals, these methods are difficult to apply and costly for poor livestock keepers. Vaccination offers a more sustainable means of controlling the disease.
Cattle can be immunized against the disease by infecting them with live parasites while simultaneously treating the animals with long-acting antibiotics. Because several strains of the parasite exist in the field, this vaccination comprises a mixture of strains. A vaccine cocktail mixing three parasite strains is being used successfully in some endemic countries, but applying this so-called ‘live vaccine’ remains hindered by difficulties in maintaining the quality of the vaccine material and in finding ways to distribute the vaccine, which needs to be kept cold, cost-effectively to widely dispersed cattle herders. In addition, it remains uncertain whether the current mix of parasite strains in the vaccine is optimal for obtaining robust immunity.
Recent studies of East Coast fever have shown that the so-called ‘protective’ proteins of the causative parasite—that is, the antigenic molecules that are recognized by the T lymphocytes of the bovine immune system and thus help animals fight development of disease—vary among the different strains of the parasite that exist in the field. This project will build on these advances to investigate the nature and extent of variability in these antigens between parasite strains. This knowledge will help scientists understand the factors that determine which parasite strains induce protective immune responses in animals that have been vaccinated.
Results of the project should provide methods for maintaining high quality of the current live vaccine and identifying parasite strains that could be incorporated into an improved second-generation live vaccine. The information should also help researchers design new, genetically engineered, vaccines, which comprise not whole parasites but rather antigenic molecules of the parasite—and thus are safer, cheaper and easier to distribute than the current live vaccine.
 
‘This is an important project for us,’ said Philip Toye, a vaccine developer from International livestock Research Institute (ILRI). ‘The information we expect to generate will greatly increase our understanding of the current live vaccine that is being used to protect animals against East Coast fever. We can use this information to get this vaccine into wider use in the region.’
 
This project is being conducted jointly by scientific groups at the universities of Edinburgh and Glasgow, in Scotland, and at ILRI, in Nairobi. The project is part of a new initiative called Combating Infectious Diseases of Livestock in Developing Countries funded by the UK’s Biotechnology and Biological Services Research Council, the UK Department for International Development and the Scottish Government. ILRI’s research in this area is also supported by members of the Consultative Group on International Agricultural Research.